CY1109090T1 - Μεθοδος για την παρασκευη ενωσεων πυραζινης - Google Patents

Μεθοδος για την παρασκευη ενωσεων πυραζινης

Info

Publication number
CY1109090T1
CY1109090T1 CY20071101230T CY071101230T CY1109090T1 CY 1109090 T1 CY1109090 T1 CY 1109090T1 CY 20071101230 T CY20071101230 T CY 20071101230T CY 071101230 T CY071101230 T CY 071101230T CY 1109090 T1 CY1109090 T1 CY 1109090T1
Authority
CY
Cyprus
Prior art keywords
preparation
pyrazine
pyrazine compounds
trichlorophenyl
diamino
Prior art date
Application number
CY20071101230T
Other languages
English (en)
Inventor
Dean David Edney
Andrew Kennedy
Original Assignee
Jazz Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jazz Pharmaceuticals Inc. filed Critical Jazz Pharmaceuticals Inc.
Publication of CY1109090T1 publication Critical patent/CY1109090T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε μία μέθοδο για την παρασκευή τόσο του παραγώγου φαινυλπυραζίνης 2,6-διαμινο-3-(2,3,5-τριχλωροφαινυλ)πυραζίνης όσο και μίας ενδιάμεσης ένωσης στην σύνθεση της 2,6-διαμινο-3-(2,3,5-τριχλωροφαινυλ)-μεθυλ]-αμινο}-ακεταμιδίνης ή ενός άλατος αυτής.
CY20071101230T 2000-05-05 2007-09-25 Μεθοδος για την παρασκευη ενωσεων πυραζινης CY1109090T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0010971.0A GB0010971D0 (en) 2000-05-05 2000-05-05 Process
EP01925711A EP1278721B1 (en) 2000-05-05 2001-05-02 Process for the preparation of pyrazine compounds

Publications (1)

Publication Number Publication Date
CY1109090T1 true CY1109090T1 (el) 2014-07-02

Family

ID=9891108

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101230T CY1109090T1 (el) 2000-05-05 2007-09-25 Μεθοδος για την παρασκευη ενωσεων πυραζινης

Country Status (12)

Country Link
US (1) US6803464B2 (el)
EP (1) EP1278721B1 (el)
JP (1) JP2003532702A (el)
AT (1) ATE365709T1 (el)
AU (1) AU2001252395A1 (el)
CY (1) CY1109090T1 (el)
DE (1) DE60129122T2 (el)
DK (1) DK1278721T3 (el)
ES (1) ES2284640T3 (el)
GB (1) GB0010971D0 (el)
PT (1) PT1278721E (el)
WO (1) WO2001085674A1 (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006214454B2 (en) * 2005-02-15 2011-05-19 Jazz Pharmaceuticals, Inc. Dosage form and method for sustained release of a substituted pyrazine compound
WO2009146112A1 (en) * 2008-04-02 2009-12-03 University Of Virginia Patent Foundation Compositions and methods for inhibiting sphingosine kinase
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
CN113473980A (zh) 2019-03-01 2021-10-01 弗拉梅尔爱尔兰有限公司 在进食状态下具有改善的药代动力学的γ-羟基丁酸酯组合物
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA26473A1 (fr) * 1997-03-01 2004-12-20 Glaxo Group Ltd Composes pharmacologiquement actifs.
GB9818881D0 (en) * 1998-08-28 1998-10-21 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
DE60129122T2 (de) 2007-10-11
EP1278721A1 (en) 2003-01-29
DK1278721T3 (da) 2007-10-01
AU2001252395A1 (en) 2001-11-20
WO2001085674A1 (en) 2001-11-15
EP1278721B1 (en) 2007-06-27
JP2003532702A (ja) 2003-11-05
DE60129122D1 (de) 2007-08-09
US20030149053A1 (en) 2003-08-07
ATE365709T1 (de) 2007-07-15
GB0010971D0 (en) 2000-06-28
US6803464B2 (en) 2004-10-12
ES2284640T3 (es) 2007-11-16
PT1278721E (pt) 2007-07-13

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