CY1108304T1 - Ψευδοπεπτιδια διεγερτες της εκκρισης αυξητικης ορμονης - Google Patents

Ψευδοπεπτιδια διεγερτες της εκκρισης αυξητικης ορμονης

Info

Publication number
CY1108304T1
CY1108304T1 CY20081100930T CY081100930T CY1108304T1 CY 1108304 T1 CY1108304 T1 CY 1108304T1 CY 20081100930 T CY20081100930 T CY 20081100930T CY 081100930 T CY081100930 T CY 081100930T CY 1108304 T1 CY1108304 T1 CY 1108304T1
Authority
CY
Cyprus
Prior art keywords
growth hormone
pseudopeptides
release
growth
mammals
Prior art date
Application number
CY20081100930T
Other languages
English (en)
Inventor
Farmaceutici Spa Mediolanum
Original Assignee
Mediolanum Farmaceutici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/835,563 external-priority patent/US7034050B2/en
Application filed by Mediolanum Farmaceutici S.P.A. filed Critical Mediolanum Farmaceutici S.P.A.
Publication of CY1108304T1 publication Critical patent/CY1108304T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με νέα εκλυτικά της αυξητικής ορμόνης ψευδοπεπτίδια τα οποία είναι ικανά να διεγείρουν την έκλυση αυξητικής ορμόνης από την υπόφυση και να προάγουν την αύξηση σε θηλαστικά. Η εφεύρεση επίσης παρέχει φαρμακευτικές συνθέσεις οι οποίες περιλαμβάνουν τα ψευδοπεπτίδια διεγέρτες της έκκρισης αυξητικής ορμόνης και μία μέθοδο για προαγωγή της έκλυσης αυξητικής ορμόνης σε θηλαστικά. Εάν χορηγούνται συνεχώς, τα παρόντα ψευδοπεπτίδια μπορεί επίσης να αναστείλουν την έκλυση της αυξητικής ορμόνης ρυθμίζοντας προς τα κάτω την αυξητική απόκριση. Μια ενδεικτική ψευδοπεπτιδική ένωση της εφεύρεσης αυτής είναι Aib-D-Trp-D-Trpψ[CH2-NH-O]Gly-NH2 (lla).
CY20081100930T 2004-04-28 2008-09-02 Ψευδοπεπτιδια διεγερτες της εκκρισης αυξητικης ορμονης CY1108304T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/835,563 US7034050B2 (en) 2004-04-28 2004-04-28 Pseudopeptides growth hormone secretagogues
US64279305P 2005-01-11 2005-01-11
EP05741341A EP1756142B1 (en) 2004-04-28 2005-04-21 Pseudopeptides growth hormone secretagogues

Publications (1)

Publication Number Publication Date
CY1108304T1 true CY1108304T1 (el) 2014-02-12

Family

ID=34967415

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100930T CY1108304T1 (el) 2004-04-28 2008-09-02 Ψευδοπεπτιδια διεγερτες της εκκρισης αυξητικης ορμονης

Country Status (11)

Country Link
EP (1) EP1756142B1 (el)
JP (1) JP2008501641A (el)
AT (1) ATE399791T1 (el)
CA (1) CA2564613A1 (el)
CY (1) CY1108304T1 (el)
DE (1) DE602005007895D1 (el)
ES (1) ES2309756T3 (el)
HK (1) HK1102373A1 (el)
PL (1) PL1756142T3 (el)
PT (1) PT1756142E (el)
WO (1) WO2005105828A1 (el)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1277113B1 (it) * 1995-12-20 1997-11-04 Romano Deghenghi Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita

Also Published As

Publication number Publication date
EP1756142B1 (en) 2008-07-02
PL1756142T3 (pl) 2008-12-31
ES2309756T3 (es) 2008-12-16
WO2005105828A1 (en) 2005-11-10
PT1756142E (pt) 2008-09-29
EP1756142A1 (en) 2007-02-28
DE602005007895D1 (de) 2008-08-14
ATE399791T1 (de) 2008-07-15
HK1102373A1 (en) 2007-11-16
JP2008501641A (ja) 2008-01-24
CA2564613A1 (en) 2005-11-10

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