WO2008154493A3 - Novel peptides that inhibit the opening of mammalian tight junctions - Google Patents

Novel peptides that inhibit the opening of mammalian tight junctions Download PDF

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Publication number
WO2008154493A3
WO2008154493A3 PCT/US2008/066327 US2008066327W WO2008154493A3 WO 2008154493 A3 WO2008154493 A3 WO 2008154493A3 US 2008066327 W US2008066327 W US 2008066327W WO 2008154493 A3 WO2008154493 A3 WO 2008154493A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibit
opening
novel peptides
tight junctions
mammalian tight
Prior art date
Application number
PCT/US2008/066327
Other languages
French (fr)
Other versions
WO2008154493A2 (en
Inventor
Amir Tamiz
Min Li
Original Assignee
Alba Therapeutics Corp
Amir Tamiz
Min Li
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alba Therapeutics Corp, Amir Tamiz, Min Li filed Critical Alba Therapeutics Corp
Publication of WO2008154493A2 publication Critical patent/WO2008154493A2/en
Publication of WO2008154493A3 publication Critical patent/WO2008154493A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides.novel peptides that inhibit and/or reduce the opening of mammalian tight junctions, i.e. tight junction antagonists. The present invention also provides methods for the treatment of excessive or undesirable permeability of a tissue by administering to a subject suffering from such a condition a composition comprising a peptide tight junction antagonist of the invention.
PCT/US2008/066327 2007-06-07 2008-06-09 Novel peptides that inhibit the opening of mammalian tight junctions WO2008154493A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US94247107P 2007-06-07 2007-06-07
US60/942,471 2007-06-07
US94839107P 2007-07-06 2007-07-06
US60/948,391 2007-07-06

Publications (2)

Publication Number Publication Date
WO2008154493A2 WO2008154493A2 (en) 2008-12-18
WO2008154493A3 true WO2008154493A3 (en) 2009-02-19

Family

ID=40130465

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/066327 WO2008154493A2 (en) 2007-06-07 2008-06-09 Novel peptides that inhibit the opening of mammalian tight junctions

Country Status (1)

Country Link
WO (1) WO2008154493A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021255955A1 (en) * 2020-04-15 2022-11-10 9 Meters Biopharma, Inc. Larazotide derivatives comprising d-amino acids
WO2022108870A1 (en) * 2020-11-17 2022-05-27 9 Meters Biopharma, Inc. Compositions and methods for treating pulmonary fibrosis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115825A1 (en) * 1998-08-03 2002-08-22 Alessio Fasano Peptide antagonists of zonulin and methods for use of the same
US20070077283A1 (en) * 2005-09-30 2007-04-05 Nastech Pharmaceutical Company Inc. Method of enhancing transmucosal delivery of therapeutic compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115825A1 (en) * 1998-08-03 2002-08-22 Alessio Fasano Peptide antagonists of zonulin and methods for use of the same
US20070077283A1 (en) * 2005-09-30 2007-04-05 Nastech Pharmaceutical Company Inc. Method of enhancing transmucosal delivery of therapeutic compounds

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Alba Therapeutics Announces Phase II Trial For Zonulin Antagonist AT-1001", MEDICAL NEWS TODAY, 22 September 2006 (2006-09-22), Retrieved from the Internet <URL:http://www.medicalnewstoday.com/articles/52442.php> *
AL-TOMA ET AL.: "Update on the management of refractory coeliac disease", J. GASTROINESTIN. LIVER DIS., vol. 16, no. 1, March 2007 (2007-03-01), pages 57 - 63 *
WADE D. ET AL.: "All-D amino acid-containing channel-forming antibiotic peptides", PROC. NATL. ACAD. SCI. (USA), vol. 87, June 1990 (1990-06-01), pages 4761 - 4765, XP000134335 *

Also Published As

Publication number Publication date
WO2008154493A2 (en) 2008-12-18

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