CY1107530T1 - Παρασιτοκτονος συνθεση μακρας δρασης πepιεχουσα μια ενωση σαλικυλανιλιδιου, ενα πολυμepικο ειδος και τουλαχιστον μια αλλη αντιπαρασιτικη ενωση - Google Patents

Παρασιτοκτονος συνθεση μακρας δρασης πepιεχουσα μια ενωση σαλικυλανιλιδιου, ενα πολυμepικο ειδος και τουλαχιστον μια αλλη αντιπαρασιτικη ενωση

Info

Publication number
CY1107530T1
CY1107530T1 CY20071100037T CY071100037T CY1107530T1 CY 1107530 T1 CY1107530 T1 CY 1107530T1 CY 20071100037 T CY20071100037 T CY 20071100037T CY 071100037 T CY071100037 T CY 071100037T CY 1107530 T1 CY1107530 T1 CY 1107530T1
Authority
CY
Cyprus
Prior art keywords
salicylanilide
antiparasic
another
treatment
composition
Prior art date
Application number
CY20071100037T
Other languages
English (en)
Inventor
William Blakely
Lillian Cromie
Sean Duffy
Original Assignee
Norbrook Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norbrook Laboratories Limited filed Critical Norbrook Laboratories Limited
Publication of CY1107530T1 publication Critical patent/CY1107530T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Μια σύνθεση παρασκευαζόμενη για την αγωγή ζώων που πάσχουν από παράσιτα τα οποία παράσιτα είναι γνωστό ότι είναι επιδεκτικά σε τουλάχιστον μία από τις αβερμεκτίνες, μιλβεμυκίνες ή σαλικυλανιλίδια, περιέχουσα για παράδειγμα ιβερμεκτίνη σε μια ποσότητα από 0,1 έως 10% (w/v), ένα διαλύτη επιλεγμένο από την ομάδα που συνίσταται από φορμάλη γλυκερόλης, προπυλενογλυκόλη, πολυαιθυλενογλυκόλη και συνδυασμούς αυτών, και ένα σαλικυλανιλίδιο όπως closantel σε μια απαιτούμενη δοσολογική ποσότητα για το υπό αγωγή ζώο, τυπικώς περίπου 2,5 mg/kg ζωντανού βάρους του υπό αγωγή ζώου, ένα πολυμερικό είδος επιλεγμένο από την ομάδα που συνίσταται από πολυβινυλοπυρρολιδόνη και αδρομερή συμπολυμερή πολυοξυπροπυλενίου/πολυοξυαιθυλενίου, όπου τα ρηθέντα πολυμερικά είδη βελτιώνουν τη βιοδιαθεσιμότητα του closantel στο βαθμό που δύνανται να επιτευχθούν επίπεδα της ρηθείσας ένωσης στο πλάσμα αίματος μεγαλύτερα από περίπου 20 ppm κατά την περίοδο αγωγής.
CY20071100037T 2002-02-28 2007-01-10 Παρασιτοκτονος συνθεση μακρας δρασης πepιεχουσα μια ενωση σαλικυλανιλιδιου, ενα πολυμepικο ειδος και τουλαχιστον μια αλλη αντιπαρασιτικη ενωση CY1107530T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0204712A GB2386066A (en) 2002-02-28 2002-02-28 Long-acting parasiticidal composition with improved bioavailability comprising a salicylanilide, a further anti-parasitic compound & a polymeric species
EP03702765A EP1478372B1 (en) 2002-02-28 2003-02-12 Long acting parasiticidal composition containing a salicylanilide compound, a polymeric species and at least one other anti-parasitic compound

Publications (1)

Publication Number Publication Date
CY1107530T1 true CY1107530T1 (el) 2013-03-13

Family

ID=9931978

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100037T CY1107530T1 (el) 2002-02-28 2007-01-10 Παρασιτοκτονος συνθεση μακρας δρασης πepιεχουσα μια ενωση σαλικυλανιλιδιου, ενα πολυμepικο ειδος και τουλαχιστον μια αλλη αντιπαρασιτικη ενωση

Country Status (23)

Country Link
US (1) US9289380B2 (el)
EP (1) EP1478372B1 (el)
JP (1) JP4480400B2 (el)
AP (1) AP1977A (el)
AR (1) AR038852A1 (el)
AT (1) ATE347897T1 (el)
AU (1) AU2003205887B2 (el)
BR (1) BR0307974B1 (el)
CA (1) CA2476520C (el)
CO (1) CO5611154A2 (el)
CR (1) CR7429A (el)
CY (1) CY1107530T1 (el)
DE (1) DE60310377T2 (el)
DK (1) DK1478372T3 (el)
EC (1) ECSP045320A (el)
ES (1) ES2275076T3 (el)
GB (1) GB2386066A (el)
MX (1) MXPA04007996A (el)
NZ (1) NZ534704A (el)
PT (1) PT1478372E (el)
SI (1) SI1478372T1 (el)
WO (1) WO2003072113A1 (el)
ZA (1) ZA200406782B (el)

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KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법

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Also Published As

Publication number Publication date
EP1478372B1 (en) 2006-12-13
CA2476520C (en) 2009-08-11
GB2386066A (en) 2003-09-10
ES2275076T3 (es) 2007-06-01
AP1977A (en) 2009-03-19
GB0204712D0 (en) 2002-04-17
AU2003205887A1 (en) 2003-09-09
ZA200406782B (en) 2005-07-27
AU2003205887B2 (en) 2007-02-15
ECSP045320A (es) 2004-11-26
WO2003072113A1 (en) 2003-09-04
JP2005525355A (ja) 2005-08-25
AR038852A1 (es) 2005-01-26
JP4480400B2 (ja) 2010-06-16
CR7429A (es) 2006-02-06
BR0307974B1 (pt) 2014-10-21
BR0307974A (pt) 2004-12-21
US20050118221A1 (en) 2005-06-02
EP1478372A1 (en) 2004-11-24
DE60310377D1 (de) 2007-01-25
MXPA04007996A (es) 2004-11-26
CA2476520A1 (en) 2003-09-04
DK1478372T3 (da) 2007-04-10
NZ534704A (en) 2007-02-23
ATE347897T1 (de) 2007-01-15
CO5611154A2 (es) 2006-02-28
PT1478372E (pt) 2007-01-31
DE60310377T2 (de) 2007-10-31
US9289380B2 (en) 2016-03-22
AP2004003142A0 (en) 2004-09-30
SI1478372T1 (sl) 2007-04-30

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