CY1107351T1 - Καινοφανης μεταλλαγμενη μορφη απιμινασης αργινινης - Google Patents
Καινοφανης μεταλλαγμενη μορφη απιμινασης αργινινηςInfo
- Publication number
- CY1107351T1 CY1107351T1 CY20081100327T CY081100327T CY1107351T1 CY 1107351 T1 CY1107351 T1 CY 1107351T1 CY 20081100327 T CY20081100327 T CY 20081100327T CY 081100327 T CY081100327 T CY 081100327T CY 1107351 T1 CY1107351 T1 CY 1107351T1
- Authority
- CY
- Cyprus
- Prior art keywords
- arginin
- present
- discloses
- arginine deiminase
- mutually mutual
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
- C12Y305/03006—Arginine deiminase (3.5.3.6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Dairy Products (AREA)
Abstract
Η παρούσα εφεύρεση φανερώνει απιμινάση αργινίνης που είναι γενετικώς τροποποιημένη για περισσότερο αποτελεσματική κατασκευή και κατεργασία. Η παρούσα εφεύρεση φανερώνει μόρια ανασυνδυασμένου DNA και φορείς και άλλες θεραπευτικές και φαρμακευτικές συνθέσεις. Η παρούσα εφεύρεση επίσης φανερώνει μεθόδους για την παρασκευή τροποποιημένης απιμινάσης αργινίνης όπως επίσης και μεθόδους για την αντιμετώπιση καρκίνου και άλλων καταστάσεων νόσου χρησιμοποιώντας τροποποιημένη απιμινάση αργινίνης.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/564,559 US6635462B1 (en) | 1997-05-12 | 2000-05-04 | Mutated form of arginine deiminase |
EP01932862A EP1278868B9 (en) | 2000-05-04 | 2001-05-02 | Mutated form of arginine deiminase |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107351T1 true CY1107351T1 (el) | 2012-12-19 |
Family
ID=24254954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100327T CY1107351T1 (el) | 2000-05-04 | 2008-03-21 | Καινοφανης μεταλλαγμενη μορφη απιμινασης αργινινης |
Country Status (11)
Country | Link |
---|---|
US (2) | US6635462B1 (el) |
EP (1) | EP1278868B9 (el) |
JP (1) | JP4709465B2 (el) |
AT (1) | ATE382697T1 (el) |
AU (1) | AU2001259353A1 (el) |
CY (1) | CY1107351T1 (el) |
DE (1) | DE60132190T2 (el) |
DK (1) | DK1278868T3 (el) |
ES (1) | ES2296750T3 (el) |
PT (1) | PT1278868E (el) |
WO (1) | WO2001083774A2 (el) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
ATE505201T1 (de) | 2002-02-14 | 2011-04-15 | Univ Leland Stanford Junior | Enzymbehandlung von nahrungsmitteln für zöliakie- sprue |
WO2004045392A2 (en) | 2002-11-20 | 2004-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnostic method for celiac sprue |
US7204980B2 (en) | 2002-11-18 | 2007-04-17 | Phoenix Pharmacologics, Inc. | Methods for inhibiting viral replication in vivo |
US7579313B2 (en) * | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
CN101002945B (zh) * | 2006-01-20 | 2012-09-05 | 清华大学 | 一种用于肿瘤治疗的新型复合物 |
CA2680590C (en) * | 2007-03-16 | 2017-10-17 | Jonathan David Gass | Combination enzyme therapy for digestion of dietary gluten |
US8148105B2 (en) * | 2007-03-16 | 2012-04-03 | The Board Of Trustees Of The Leland Stanford Junior University | Scaleable manufacturing process for cysteine endoprotease B, isoform 2 |
EP2295560A1 (en) | 2009-09-14 | 2011-03-16 | RWTH Aachen University | Directed evolution of arginine deiminase for increased activity at physiological pH |
US11123230B2 (en) * | 2011-11-22 | 2021-09-21 | Kimberly-Clark Worldwide, Inc. | Method of folding pant-like disposable absorbent garments in a chute |
US9918881B2 (en) | 2011-11-22 | 2018-03-20 | Kimberly-Clark Worldwide, Inc. | Method of folding pant-like disposable absorbent garments in a trough |
US10118754B2 (en) * | 2011-11-22 | 2018-11-06 | Kimberly-Clark Worldwide, Inc. | Method of folding pant-like disposable absorbent garments in a chute |
TW201735943A (zh) | 2012-04-04 | 2017-10-16 | 普拉瑞斯集團 | 利用精胺酸去亞胺酶之治療方法 |
CN105188739B (zh) * | 2013-03-15 | 2017-06-23 | 波拉里集团 | 用于癌症治疗的具有减弱的对adi‑peg 20抗体的交叉反应性的精氨酸脱亚胺酶 |
TWI676683B (zh) * | 2014-03-14 | 2019-11-11 | 開曼群島商瑞華藥業集團 | 用於癌症治療之對adi-peg20抗體交叉反應性降低之精胺酸去亞胺酶 |
WO2015143006A1 (en) | 2014-03-18 | 2015-09-24 | Tdw Group | Engineered chimeric pegylated adi and methods of use |
CA2961602A1 (en) | 2014-09-16 | 2016-03-24 | Polaris Group | Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment |
CN104726478A (zh) * | 2015-03-09 | 2015-06-24 | 武汉远大弘元股份有限公司 | 表达精氨酸脱亚胺酶基因的重组大肠杆菌及其应用 |
US10435682B2 (en) | 2016-02-19 | 2019-10-08 | University Of South Florida | Arginine deiminase gene therapy for disordered proteins |
CN108265044B (zh) * | 2016-12-31 | 2021-05-11 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇定点修饰的精氨酸脱亚胺酶及其制备方法与应用 |
CN112442496B (zh) * | 2019-08-28 | 2023-05-12 | 江苏众红生物工程创药研究院有限公司 | 精氨酸脱亚胺酶突变体及其应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
JP2900279B2 (ja) | 1989-08-02 | 1999-06-02 | 株式会社ジャパンエナジー | 新規なアルギニンデイミナーゼ、その製造法及び該酵素を有効成分とする制癌剤 |
JP2736145B2 (ja) | 1990-01-11 | 1998-04-02 | 関東電化工業株式会社 | パーハロゲン化エチレンの製造法 |
JP3209338B2 (ja) | 1990-09-10 | 2001-09-17 | 株式会社ジャパンエナジー | ポリエチレングリコール修飾アルギニンデイミナーゼおよびその製造法 |
US5372942A (en) | 1992-02-10 | 1994-12-13 | Coriell Institute For Medical Research | Protease K resistant arginine deiminase, its method of preparation and its use as an anti-neoplastic agent |
US5804183A (en) | 1997-01-31 | 1998-09-08 | Enzon, Inc. | Arginine deminase derived from mycoplasma arthritidis and polymer conjugates containing the same |
JP2001511162A (ja) * | 1997-02-06 | 2001-08-07 | ノボ ノルディスク アクティーゼルスカブ | 付加され、そして/又は除去された付着基を有するポリペプチド−ポリマー結合体 |
US6183738B1 (en) | 1997-05-12 | 2001-02-06 | Phoenix Pharamacologics, Inc. | Modified arginine deiminase |
US6180387B1 (en) | 1997-08-11 | 2001-01-30 | Smithkline Beecham Corporation | Arginine deiminase |
-
2000
- 2000-05-04 US US09/564,559 patent/US6635462B1/en not_active Expired - Lifetime
-
2001
- 2001-05-02 JP JP2001580381A patent/JP4709465B2/ja not_active Expired - Lifetime
- 2001-05-02 AT AT01932862T patent/ATE382697T1/de active
- 2001-05-02 DE DE60132190T patent/DE60132190T2/de not_active Expired - Lifetime
- 2001-05-02 AU AU2001259353A patent/AU2001259353A1/en not_active Abandoned
- 2001-05-02 DK DK01932862T patent/DK1278868T3/da active
- 2001-05-02 WO PCT/US2001/014116 patent/WO2001083774A2/en active IP Right Grant
- 2001-05-02 PT PT01932862T patent/PT1278868E/pt unknown
- 2001-05-02 ES ES01932862T patent/ES2296750T3/es not_active Expired - Lifetime
- 2001-05-02 EP EP01932862A patent/EP1278868B9/en not_active Expired - Lifetime
-
2003
- 2003-08-21 US US10/645,723 patent/US20040258675A1/en not_active Abandoned
-
2008
- 2008-03-21 CY CY20081100327T patent/CY1107351T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE60132190D1 (de) | 2008-02-14 |
US6635462B1 (en) | 2003-10-21 |
DE60132190T2 (de) | 2008-12-11 |
PT1278868E (pt) | 2008-04-11 |
JP4709465B2 (ja) | 2011-06-22 |
WO2001083774A3 (en) | 2002-05-23 |
ES2296750T3 (es) | 2008-05-01 |
EP1278868A2 (en) | 2003-01-29 |
EP1278868B9 (en) | 2008-10-29 |
US20040258675A1 (en) | 2004-12-23 |
JP2003533186A (ja) | 2003-11-11 |
EP1278868B1 (en) | 2008-01-02 |
AU2001259353A1 (en) | 2001-11-12 |
DK1278868T3 (da) | 2008-05-19 |
ATE382697T1 (de) | 2008-01-15 |
WO2001083774A2 (en) | 2001-11-08 |
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