CY1106455T1 - Τροποποιητικα αντισωματα καρκινικης νοσου - Google Patents

Τροποποιητικα αντισωματα καρκινικης νοσου

Info

Publication number
CY1106455T1
CY1106455T1 CY20071100326T CY071100326T CY1106455T1 CY 1106455 T1 CY1106455 T1 CY 1106455T1 CY 20071100326 T CY20071100326 T CY 20071100326T CY 071100326 T CY071100326 T CY 071100326T CY 1106455 T1 CY1106455 T1 CY 1106455T1
Authority
CY
Cyprus
Prior art keywords
antibodies
tumor
cancer
modifying antibodies
toxins
Prior art date
Application number
CY20071100326T
Other languages
English (en)
Inventor
David S. F. Young
Susan E. Hahn
Original Assignee
Arius Research, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arius Research, Inc. filed Critical Arius Research, Inc.
Publication of CY1106455T1 publication Critical patent/CY1106455T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Abstract

Η παρούσα εφεύρεση σχετίζεται με μία μέθοδο για την παραγωγή τροποποιητικών αντισωμάτων καρκινικής νόσου για ασθενείς χρησιμοποιώντας ένα καινοφανές παράδειγμα διαλογής. Διαχωρίζοντας τα αντι-καρκινικά αντισώματα χρησιμοποιώντας την κυτταροτοξικότητα καρκινικών κυττάρων ως ένα τελικό σημείο, η διεργασία κάνει δυνατή την παραγωγή αντι-καρκινικών αντισωμάτων για θεραπευτικούς και διαγνωστικούς σκοπούς. Τα αντισώματα μπορούν να χρησιμοποιηθούν σε βοήθεια της σταδιοποίησης και διάγνωσης καρκίνου, και μπορούν να χρησιμοποιηθούν για την αντιμετώπιση πρωτογενών όγκων και μεταστάσεων όγκων. Τα αντικαρκινικά αντισώματα μπορούν να συζευχθούν σε τοξίνες, ένζυμα, ραδιενεργές ενώσεις, και αιματογενή κύτταρα.
CY20071100326T 2003-04-14 2007-03-08 Τροποποιητικα αντισωματα καρκινικης νοσου CY1106455T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/413,755 US6794494B1 (en) 2003-04-14 2003-04-14 Cancerous disease modifying antibodies
PCT/CA2004/000481 WO2004089989A1 (en) 2003-04-14 2004-03-31 Cancerous disease modifying antibodies

Publications (1)

Publication Number Publication Date
CY1106455T1 true CY1106455T1 (el) 2011-10-12

Family

ID=32990305

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100326T CY1106455T1 (el) 2003-04-14 2007-03-08 Τροποποιητικα αντισωματα καρκινικης νοσου

Country Status (16)

Country Link
US (1) US6794494B1 (el)
EP (2) EP1757620A3 (el)
JP (1) JP2007523838A (el)
CN (1) CN100588662C (el)
AT (1) ATE348112T1 (el)
AU (1) AU2004228078A1 (el)
CA (1) CA2521375A1 (el)
CY (1) CY1106455T1 (el)
DE (1) DE602004003689T2 (el)
DK (1) DK1613656T3 (el)
ES (1) ES2278309T3 (el)
NZ (1) NZ542927A (el)
PL (1) PL1613656T3 (el)
PT (1) PT1613656E (el)
SI (1) SI1613656T1 (el)
WO (1) WO2004089989A1 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772372B2 (en) * 2002-07-04 2010-08-10 Patrys Limited Neoplasm specific antibodies and uses thereof
US20080025977A1 (en) * 2003-04-14 2008-01-31 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of CD59
US7195764B2 (en) * 2003-04-14 2007-03-27 Arius Research Inc. Cancerous disease modifying antibodies
US20060140963A1 (en) * 2003-04-14 2006-06-29 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of CD59
US20080213169A1 (en) * 2003-04-14 2008-09-04 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of CD59
US7348413B2 (en) * 2004-02-26 2008-03-25 Arius Research Inc. Cancerous disease modifying antibodies
US7452978B2 (en) * 2005-08-02 2008-11-18 Arius Research, Inc. Cancerous disease modifying antibodies
US7494648B2 (en) 2005-08-02 2009-02-24 Hoffmann-La Roche Inc. Cancerous disease modifying antibodies
US7456258B2 (en) * 2005-08-02 2008-11-25 Arius Research, Inc. Cancerous disease modifying antibodies
US8003761B2 (en) * 2007-01-23 2011-08-23 Hoffmann-La Roche Inc. Cancerous disease modifying antibodies
CA2731129A1 (en) * 2008-07-17 2010-01-21 Helen P. Findlay Cancerous disease modifying antibodies
AU2011222012C1 (en) 2010-03-02 2015-02-26 Kyowa Kirin Co., Ltd. Modified antibody composition
EP3659625A1 (en) 2014-10-23 2020-06-03 Innate Pharma Treatment of cancers using anti-nkg2a agents
WO2020136147A1 (en) 2018-12-26 2020-07-02 Innate Pharma Compounds and methods for treatment of head and neck cancer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4828991A (en) 1984-01-31 1989-05-09 Akzo N.V. Tumor specific monoclonal antibodies
US4753894A (en) * 1984-02-08 1988-06-28 Cetus Corporation Monoclonal anti-human breast cancer antibodies
EP0199141A3 (en) * 1985-04-19 1988-07-20 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies to human gastrointestinal cancer
AU613590B2 (en) 1986-11-19 1991-08-08 Bristol-Myers Squibb Company Hybridomas producing monoclonal antibodies to new mucin epitopes
US4861581A (en) 1986-12-05 1989-08-29 Cancer Biologics, Inc. Detection of necrotic malignant tissue and associated therapy
US5338832A (en) * 1987-07-02 1994-08-16 Akzo N.V. Antigen recognized by MCA 16-88
US5171665A (en) 1989-04-17 1992-12-15 Oncogen Monoclonal antibody to novel antigen associated with human tumors
US6020145A (en) 1989-06-30 2000-02-01 Bristol-Myers Squibb Company Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96
EP0539970B1 (en) 1991-10-30 1999-05-26 Idemitsu Kosan Company Limited Methods for producing human lymphocytes and human monoclonal antibodies, and human monoclonal antibodies produced thereby
WO1993016185A2 (en) * 1992-02-06 1993-08-19 Creative Biomolecules, Inc. Biosynthetic binding protein for cancer marker
IL105008A0 (en) 1992-03-13 1993-07-08 Yeda Res & Dev Double transfectants of mhc genes as cellular vaccines for immunoprevention of tumor metastasis
WO1994018562A1 (en) 1993-02-05 1994-08-18 Epigen, Inc. Human carcinoma antigen (hca), hca antibodies, hca immunoassays, methods of imaging and therapy
EP0764030B1 (en) 1994-06-24 2000-09-20 Vladimir P. Torchilin Composition containing autoantibodies for tumor therapy and prophylaxis
US5783186A (en) 1995-12-05 1998-07-21 Amgen Inc. Antibody-induced apoptosis
US6376654B1 (en) * 1999-08-13 2002-04-23 Molecular Discoveries, Llc Myeloma cell and ovarian cancer cell surface glycoproteins, antibodies thereto, and uses thereof
US6180357B1 (en) * 1999-10-08 2001-01-30 Arius Research, Inc. Individualized patient-specific anti-cancer antibodies
DK2163256T3 (en) * 2001-05-11 2015-12-07 Ludwig Inst For Cancer Res Ltd Specific binding proteins and use thereof

Also Published As

Publication number Publication date
JP2007523838A (ja) 2007-08-23
DE602004003689T2 (de) 2007-10-04
PL1613656T3 (pl) 2007-04-30
EP1757620A3 (en) 2007-11-21
PT1613656E (pt) 2007-02-28
EP1613656B1 (en) 2006-12-13
SI1613656T1 (sl) 2007-04-30
DE602004003689D1 (de) 2007-01-25
WO2004089989A1 (en) 2004-10-21
NZ542927A (en) 2008-04-30
CA2521375A1 (en) 2004-10-21
EP1613656A1 (en) 2006-01-11
ATE348112T1 (de) 2007-01-15
ES2278309T3 (es) 2007-08-01
EP1757620A2 (en) 2007-02-28
CN100588662C (zh) 2010-02-10
US6794494B1 (en) 2004-09-21
DK1613656T3 (da) 2007-03-12
CN1802387A (zh) 2006-07-12
AU2004228078A1 (en) 2004-10-21

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