CY1106187T1 - Γονιδιο καταστολης - Google Patents
Γονιδιο καταστοληςInfo
- Publication number
- CY1106187T1 CY1106187T1 CY20061101430T CY061101430T CY1106187T1 CY 1106187 T1 CY1106187 T1 CY 1106187T1 CY 20061101430 T CY20061101430 T CY 20061101430T CY 061101430 T CY061101430 T CY 061101430T CY 1106187 T1 CY1106187 T1 CY 1106187T1
- Authority
- CY
- Cyprus
- Prior art keywords
- gene
- modulating
- tumor suppressor
- encode polypeptides
- polypeptides capable
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108700025716 Tumor Suppressor Genes Proteins 0.000 abstract 1
- 102000044209 Tumor Suppressor Genes Human genes 0.000 abstract 1
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 abstract 1
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 108700025694 p53 Genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Audible-Bandwidth Dynamoelectric Transducers Other Than Pickups (AREA)
- Bipolar Transistors (AREA)
Abstract
Η εφεύρεση σχετίζεται με την ταυτοποίηση ενός νέου μέλους της οικογένειας των γονιδίων καταστολής νεοπλασίας (πρωτεϊνών διέγερσης της απόπτωσης ASP's) που κωδικοποιούν πολυπεπτίδια ικανά να διαμορφώνουν τη δράση του γονιδίου p53 και κωδικοποιούν επίσης και πολυπεπτίδια ικανά να διαμορφώνουν τη δράση του εν λόγω πολυπεπτιδίου καταστολής νεοπλασίας.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0019018A GB0019018D0 (en) | 2000-08-04 | 2000-08-04 | Suppressor gene |
GB0029996A GB0029996D0 (en) | 2000-12-08 | 2000-12-08 | Suppressor gene |
GB0112890A GB0112890D0 (en) | 2001-05-26 | 2001-05-26 | Suppressor Gene |
PCT/GB2001/003524 WO2002012325A2 (en) | 2000-08-04 | 2001-08-06 | Suppressor gene |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106187T1 true CY1106187T1 (el) | 2011-06-08 |
Family
ID=27255828
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101430T CY1106187T1 (el) | 2000-08-04 | 2006-10-04 | Γονιδιο καταστολης |
Country Status (14)
Country | Link |
---|---|
US (1) | US20040053262A1 (el) |
EP (2) | EP1710582A3 (el) |
JP (1) | JP2004525605A (el) |
CN (1) | CN1310942C (el) |
AT (1) | ATE332309T1 (el) |
AU (2) | AU2001276515B2 (el) |
CA (1) | CA2417368A1 (el) |
CY (1) | CY1106187T1 (el) |
DE (1) | DE60121346T8 (el) |
DK (1) | DK1313762T3 (el) |
ES (1) | ES2269430T3 (el) |
HK (1) | HK1057377A1 (el) |
PT (1) | PT1313762E (el) |
WO (1) | WO2002012325A2 (el) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6852108B2 (en) | 2002-05-14 | 2005-02-08 | Spiration, Inc. | Apparatus and method for resecting and removing selected body tissue from a site inside a patient |
GB0223187D0 (en) * | 2002-10-07 | 2002-11-13 | Ludwig Inst Cancer Res | Screen |
CA2487206A1 (en) | 2002-10-07 | 2004-04-15 | Ludwig Institute Cancer Research | P53 binding polypeptide |
EP1690094A1 (en) * | 2003-12-04 | 2006-08-16 | Ludwig Institute For Cancer Research | Screening assay and treatment |
WO2005054509A2 (en) * | 2003-12-04 | 2005-06-16 | Ludwig Institute For Cancer Research | Assay and treatment |
GB0328690D0 (en) * | 2003-12-10 | 2004-01-14 | Ludwig Inst Cancer Res | Tumour suppressor protein |
EP1725678A1 (en) * | 2004-03-12 | 2006-11-29 | Ludwig Institute For Cancer Research | Differential drug sensitivity |
EP2270512B1 (en) * | 2004-12-08 | 2016-03-23 | Cedars-Sinai Medical Center | Methods for diagnosis of Crohn's disease |
CA2592172C (en) | 2005-01-20 | 2016-06-14 | Medical Research Council | Modulators of itch ubiquitinase activity |
US20100035257A1 (en) * | 2006-10-06 | 2010-02-11 | The General Hospital Corporation | Methods to determine the responsiveness to cisplatin treatment |
US20100021917A1 (en) * | 2007-02-14 | 2010-01-28 | Cedars-Sinai Medical Center | Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease |
US20100190162A1 (en) * | 2007-02-26 | 2010-07-29 | Cedars-Sinai Medical Center | Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease |
WO2010039931A2 (en) * | 2008-10-01 | 2010-04-08 | Cedars-Sinai Medical Center | Methods of using il17rd and il23-il17 pathway genes to diagnose crohn's disease |
WO2008137762A2 (en) * | 2007-05-04 | 2008-11-13 | Cedars-Sinai Medical Center | Methods of diagnosis and treatment of crohn's disease |
US20100015156A1 (en) * | 2007-03-06 | 2010-01-21 | Cedars-Sinai Medical Center | Diagnosis of inflammatory bowel disease in children |
US8486640B2 (en) | 2007-03-21 | 2013-07-16 | Cedars-Sinai Medical Center | Ileal pouch-anal anastomosis (IPAA) factors in the treatment of inflammatory bowel disease |
US20100184050A1 (en) * | 2007-04-26 | 2010-07-22 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease in the puerto rican population |
US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
WO2010075579A2 (en) | 2008-12-24 | 2010-07-01 | Cedars-Sinai Medical Center | Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy |
JP2013504586A (ja) * | 2009-09-10 | 2013-02-07 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 脱ユビキチン化酵素およびユビキチン化ポリペプチドを調節するための方法および材料 |
EP2820041B1 (en) | 2012-03-02 | 2017-06-14 | Ludwig Institute For Cancer Research Ltd. | Iaspp phosphorylation and metastatic potential |
KR20210157418A (ko) | 2013-03-27 | 2021-12-28 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전 |
EP4105236A1 (en) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease |
AU2016356395B2 (en) | 2015-11-19 | 2020-12-17 | Cygnus Biosciences (Beijing) Co. Ltd. | Methods for obtaining and correcting biological sequence information |
CN106874709B (zh) * | 2015-12-12 | 2019-03-01 | 北京大学 | 测序结果中序列数据错误的检测和校正方法 |
EP3430172A4 (en) | 2016-03-17 | 2019-08-21 | Cedars-Sinai Medical Center | METHOD FOR DIAGNOSIS OF INFLAMMATORY ENDURANCE THROUGH RNASET2 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5876950A (en) * | 1995-01-26 | 1999-03-02 | Bristol-Myers Squibb Company | Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy |
US5977311A (en) * | 1997-09-23 | 1999-11-02 | Curagen Corporation | 53BP2 complexes |
JP2003517274A (ja) * | 1998-10-05 | 2003-05-27 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | 癌関連抗原およびその使用 |
US7141384B1 (en) * | 1998-10-06 | 2006-11-28 | Georgetown University | Detection of pleiotrophin |
WO2000032628A1 (fr) * | 1998-12-03 | 2000-06-08 | Ono Pharmaceutical Co., Ltd. | INHIBITEUR DE LIAISON DE Re1A, PROCEDE DE PRODUCTION CORRESPONDANT ET UTILISATION DUDIT INHIBITEUR DE LIAISON |
WO2001053312A1 (en) * | 1999-12-23 | 2001-07-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
EP1572987A4 (en) * | 2000-02-03 | 2005-11-30 | Nuvelo Inc | NUCLEIC ACIDS AND POLYPEPTIDES |
-
2001
- 2001-08-06 CN CNB018138594A patent/CN1310942C/zh not_active Expired - Fee Related
- 2001-08-06 PT PT01954168T patent/PT1313762E/pt unknown
- 2001-08-06 DE DE60121346T patent/DE60121346T8/de active Active
- 2001-08-06 AU AU2001276515A patent/AU2001276515B2/en not_active Ceased
- 2001-08-06 US US10/343,649 patent/US20040053262A1/en not_active Abandoned
- 2001-08-06 ES ES01954168T patent/ES2269430T3/es not_active Expired - Lifetime
- 2001-08-06 EP EP06076277A patent/EP1710582A3/en not_active Withdrawn
- 2001-08-06 AU AU7651501A patent/AU7651501A/xx active Pending
- 2001-08-06 EP EP01954168A patent/EP1313762B1/en not_active Expired - Lifetime
- 2001-08-06 AT AT01954168T patent/ATE332309T1/de not_active IP Right Cessation
- 2001-08-06 WO PCT/GB2001/003524 patent/WO2002012325A2/en active IP Right Grant
- 2001-08-06 CA CA002417368A patent/CA2417368A1/en not_active Abandoned
- 2001-08-06 JP JP2002518296A patent/JP2004525605A/ja active Pending
- 2001-08-06 DK DK01954168T patent/DK1313762T3/da active
-
2003
- 2003-11-28 HK HK03108730A patent/HK1057377A1/xx not_active IP Right Cessation
-
2006
- 2006-10-04 CY CY20061101430T patent/CY1106187T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE332309T1 (de) | 2006-07-15 |
DE60121346D1 (en) | 2006-08-17 |
CN1310942C (zh) | 2007-04-18 |
DK1313762T3 (da) | 2006-10-30 |
HK1057377A1 (en) | 2004-04-02 |
DE60121346T8 (de) | 2007-12-13 |
AU7651501A (en) | 2002-02-18 |
CN1446228A (zh) | 2003-10-01 |
PT1313762E (pt) | 2006-11-30 |
EP1313762A2 (en) | 2003-05-28 |
AU2001276515B2 (en) | 2006-10-12 |
DE60121346T2 (de) | 2007-07-19 |
US20040053262A1 (en) | 2004-03-18 |
CA2417368A1 (en) | 2002-02-14 |
EP1313762B1 (en) | 2006-07-05 |
EP1710582A2 (en) | 2006-10-11 |
WO2002012325A3 (en) | 2003-03-06 |
EP1710582A3 (en) | 2006-11-02 |
WO2002012325A2 (en) | 2002-02-14 |
ES2269430T3 (es) | 2007-04-01 |
JP2004525605A (ja) | 2004-08-26 |
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