CY1106181T1 - Φαρμακευτικος σχηματισμος ο οποιος πepιλαμβανει γλυκινη σαν ενα σταθepοποιητη - Google Patents

Φαρμακευτικος σχηματισμος ο οποιος πepιλαμβανει γλυκινη σαν ενα σταθepοποιητη

Info

Publication number
CY1106181T1
CY1106181T1 CY20061101417T CY061101417T CY1106181T1 CY 1106181 T1 CY1106181 T1 CY 1106181T1 CY 20061101417 T CY20061101417 T CY 20061101417T CY 061101417 T CY061101417 T CY 061101417T CY 1106181 T1 CY1106181 T1 CY 1106181T1
Authority
CY
Cyprus
Prior art keywords
stabilizer
pharmaceutical formulation
formulation containing
hours
containing glycine
Prior art date
Application number
CY20061101417T
Other languages
English (en)
Inventor
James Mcshane
Ray Wood
Sumio Watanabe
Kiyoshi Iwamoto
Katsumi Onai
Original Assignee
Eisai R&D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co., Ltd. filed Critical Eisai R&D Management Co., Ltd.
Publication of CY1106181T1 publication Critical patent/CY1106181T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Abstract

Η παρούσα εφεύρεση παρέχει φαρμακευτικούς σχηματισμούς κατάλληλους για ενδοφλέβια έγχυση οι οποίοι περιλαμβάνουν ένα λυοφιλισμένο αντί-ελκωτικό παράγοντα υποκείμενο σε ανασύσταση σε ισοτονικά διαλύματα κατάλληλα για ενδοφλέβια χορήγηση, όπως 5% δεξτρόζη ή 0,9% χλωριούχο νάτριο. Τα διαλύματα φέρνονται σε ένα pΗ μεταξύ περίπου 9 και περίπου 12, κατά προτίμηση μεταξύ περίπου pΗ 10 και 11, με ένα ρυθμιστικό γλυκίνης-υδροξειδίου νατρίου. Αυτοί οι σχηματισμοί είναι χημικά και φυσικά σταθεροί, και δεν αλλάζουν χρώμα σε σημαντικό βαθμό, για τουλάχιστον μεταξύ περίπου 6 και περίπου 12 ωρών σε θερμοκρασία δωματίου, και είναι σταθεροί σε αλλαγή χρώματος για από μεταξύ περίπου 24 και 48 ωρών εάν κρατηθούν στους 5°C.
CY20061101417T 1997-10-14 2006-09-29 Φαρμακευτικος σχηματισμος ο οποιος πepιλαμβανει γλυκινη σαν ενα σταθepοποιητη CY1106181T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6208997P 1997-10-14 1997-10-14
PCT/US1998/021972 WO1999018959A1 (en) 1997-10-14 1998-09-14 Pharmaceutical formulation comprising glycine as a stabilizer

Publications (1)

Publication Number Publication Date
CY1106181T1 true CY1106181T1 (el) 2011-06-08

Family

ID=22040157

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101417T CY1106181T1 (el) 1997-10-14 2006-09-29 Φαρμακευτικος σχηματισμος ο οποιος πepιλαμβανει γλυκινη σαν ενα σταθepοποιητη

Country Status (11)

Country Link
EP (1) EP1039905B1 (el)
JP (1) JP3459407B2 (el)
AT (1) ATE332133T1 (el)
AU (1) AU1361399A (el)
CA (1) CA2308143A1 (el)
CY (1) CY1106181T1 (el)
DE (1) DE69835165T2 (el)
DK (1) DK1039905T3 (el)
ES (1) ES2268800T3 (el)
PT (1) PT1039905E (el)
WO (1) WO1999018959A1 (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7396841B2 (en) * 2000-08-18 2008-07-08 Takeda Pharmaceutical Company Limited Injections
MY137726A (en) 2000-11-22 2009-03-31 Nycomed Gmbh Freeze-dried pantoprazole preparation and pantoprazole injection
JPWO2003082854A1 (ja) * 2002-03-29 2005-08-04 ゼリア新薬工業株式会社 １−ｎ−アミノベンズイミダゾール誘導体
GB2404856B8 (en) * 2003-08-18 2008-03-13 Cadila Pharm Ltd Stable pharmaceutical composition of rabeprazole
DE102004007854A1 (de) * 2004-02-17 2005-09-01 Hexal Ag Stabile, wässrige Formulierung für Benzimidazole
CN104840431B (zh) * 2014-02-13 2017-09-08 长春海悦药业股份有限公司 一种含有伏立康唑的药物组合物
CN112807282A (zh) * 2021-01-13 2021-05-18 海南葫芦娃药业集团股份有限公司 一种奥美拉唑钠冻干粉针剂及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5610110A (en) * 1979-07-06 1981-02-02 Green Cross Corp:The Acetyl salicylate salt preparation for injection
JPS5665816A (en) * 1979-11-01 1981-06-03 Green Cross Corp:The Acetylsalicylate pharmaceutical for injection
EP0082481B2 (en) * 1981-12-23 1990-09-12 Schering Corporation Stabilised alpha-interferon formulations and their preparation
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
JPH0594225A (ja) * 1991-09-30 1993-04-16 Toshiba Corp セキユリテイ機能を内蔵したパーソナルコンピユータ
JPH05194225A (ja) * 1991-11-07 1993-08-03 Yoshitomi Pharmaceut Ind Ltd 安定化された抗潰瘍剤含有製剤
US6270757B1 (en) * 1994-04-21 2001-08-07 Genetics Institute, Inc. Formulations for IL-11

Also Published As

Publication number Publication date
PT1039905E (pt) 2006-11-30
DE69835165T2 (de) 2007-06-06
WO1999018959A9 (en) 1999-08-05
ATE332133T1 (de) 2006-07-15
JP2001519390A (ja) 2001-10-23
DE69835165D1 (de) 2006-08-17
CA2308143A1 (en) 1999-04-22
WO1999018959A1 (en) 1999-04-22
EP1039905A1 (en) 2000-10-04
DK1039905T3 (da) 2006-11-06
ES2268800T3 (es) 2007-03-16
JP3459407B2 (ja) 2003-10-20
EP1039905B1 (en) 2006-07-05
AU1361399A (en) 1999-05-03

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