CU20200102A7 - Compuestos derivados de isoindolin-1,2,4-triazol-3-carbonitrilo útiles para el tratamiento de enfermedades cinetoplastídicas - Google Patents

Compuestos derivados de isoindolin-1,2,4-triazol-3-carbonitrilo útiles para el tratamiento de enfermedades cinetoplastídicas

Info

Publication number
CU20200102A7
CU20200102A7 CU2020000102A CU20200102A CU20200102A7 CU 20200102 A7 CU20200102 A7 CU 20200102A7 CU 2020000102 A CU2020000102 A CU 2020000102A CU 20200102 A CU20200102 A CU 20200102A CU 20200102 A7 CU20200102 A7 CU 20200102A7
Authority
CU
Cuba
Prior art keywords
kinetoplastid
isoindolin
carbonitrile
triazol
diseases
Prior art date
Application number
CU2020000102A
Other languages
English (en)
Inventor
Jan Jiricek
Shuyi Pearly Ng
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20200102A7 publication Critical patent/CU20200102A7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<p>La presente invención proporciona un compuesto de la fórmula (I), o una sal farmacéuticamente aceptable del mismo:</p> <p>en donde R1, R2, R3 y R4 han sido definidos en la presente. la presente invención además proporciona usos terapéuticos de esos compuestos, por ejemplo contra tripanosomiasis africana humana; composiciones farmacéuticas que comprenden estos compuestos y composiciones que comprenden estos compuestos con un coagente terapéutico.</p>
CU2020000102A 2018-06-19 2019-06-18 Compuestos derivados de isoindolin-1,2,4-triazol-3-carbonitrilo útiles para el tratamiento de enfermedades cinetoplastídicas CU20200102A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862687045P 2018-06-19 2018-06-19
PCT/IB2019/055123 WO2019244049A1 (en) 2018-06-19 2019-06-18 Cyanotriazole compounds and uses thereof

Publications (1)

Publication Number Publication Date
CU20200102A7 true CU20200102A7 (es) 2021-08-06

Family

ID=67841115

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2020000102A CU20200102A7 (es) 2018-06-19 2019-06-18 Compuestos derivados de isoindolin-1,2,4-triazol-3-carbonitrilo útiles para el tratamiento de enfermedades cinetoplastídicas

Country Status (21)

Country Link
US (1) US20220106296A1 (es)
EP (1) EP3810598A1 (es)
JP (1) JP2021528397A (es)
KR (1) KR20210022646A (es)
CN (1) CN112313217A (es)
AU (1) AU2019291490B2 (es)
BR (1) BR112020025538A2 (es)
CA (1) CA3100954A1 (es)
CL (1) CL2020003252A1 (es)
CR (1) CR20200619A (es)
CU (1) CU20200102A7 (es)
EA (1) EA202190064A1 (es)
EC (1) ECSP20080991A (es)
IL (1) IL279483A (es)
JO (1) JOP20200327A1 (es)
MA (1) MA52977A (es)
MX (1) MX2020013729A (es)
PE (1) PE20210780A1 (es)
PH (1) PH12020552186A1 (es)
SG (1) SG11202012628XA (es)
WO (1) WO2019244049A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115181060B (zh) * 2022-08-19 2024-03-19 江苏禾裕泰化学有限公司 一种生产2-氨基-3-氯-5-三氟甲基吡啶的清洁生产工艺
CN116284772B (zh) * 2023-02-09 2024-02-27 四川大学 一种联吡啶三唑共价有机聚合物及其制备方法和应用
CN116836111A (zh) * 2023-09-01 2023-10-03 峰成医药科技(天津)有限公司 一种氟代吡啶的连续化合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078163A2 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
US8642774B2 (en) * 2011-12-08 2014-02-04 Boehringer Ingelheim International Gmbh Compounds
AU2012354094C1 (en) * 2011-12-15 2015-10-15 Novartis Ag Use of inhibitors of the activity or function of PI3K
US20170368034A1 (en) * 2014-12-22 2017-12-28 Glaxosmithkline Intellectual Property Development Limited Thiotriazole compound and its use in parasitic protozoal infections

Also Published As

Publication number Publication date
CL2020003252A1 (es) 2021-07-09
MX2020013729A (es) 2021-05-12
ECSP20080991A (es) 2021-02-26
CN112313217A (zh) 2021-02-02
WO2019244049A1 (en) 2019-12-26
CA3100954A1 (en) 2019-12-26
AU2019291490A1 (en) 2021-02-04
JOP20200327A1 (ar) 2020-12-15
SG11202012628XA (en) 2021-01-28
IL279483A (en) 2021-01-31
EA202190064A1 (ru) 2021-03-29
JP2021528397A (ja) 2021-10-21
CR20200619A (es) 2021-01-21
AU2019291490B2 (en) 2022-02-10
US20220106296A1 (en) 2022-04-07
MA52977A (fr) 2021-04-28
EP3810598A1 (en) 2021-04-28
PH12020552186A1 (en) 2021-06-07
PE20210780A1 (es) 2021-04-21
KR20210022646A (ko) 2021-03-03
BR112020025538A2 (pt) 2021-03-16

Similar Documents

Publication Publication Date Title
DOP2020000037A (es) Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
CL2020003252A1 (es) Compuestos de cianotriazol y usos de los mismos
PH12020551821A1 (en) Novel compounds
CL2021000382A1 (es) Compuestos novedosos de sulfonamidaurea
TN2015000391A1 (en) Compounds and compositions for the treatment of parasitic diseases
CO2019015090A2 (es) Métodos de tratamiento para la fibrosis cística
UY38625A (es) Compuestos y su uso en el tratamiento del cáncer
ECSP20035590A (es) Derivado de oxi-fluoropiperidina como inhibidor de quinasa
ECSP21018584A (es) Dioxociclobutenilamino-3-hidroxi-picolinamidas n-sustituidas útiles como inhibidores de ccr6
NI202000058A (es) Moduladores de sting (estimulador de genes de interferón) a base de ciclopentano
PH12016501198A1 (en) Compounds and compositions for the treatment of parasitic diseases
WO2014151630A3 (en) Compounds and compositions for the treatment of parasitic diseases
CL2020001020A1 (es) Derivados de bencimidazol y sus usos.
EA202091604A1 (ru) Ингибирование ионного канала a1 с транзиторным рецепторным потенциалом
UY38892A (es) Moduladores de sting (estimulador de genes de interferón)
EA202191955A1 (ru) Таблетированные составы с модифицированным высвобождением, содержащие ингибиторы фосфодиэстеразы
AR114082A1 (es) INHIBIDORES DE LA PI4KIIIb
CL2021002205A1 (es) Compuesto heterocíclico, composición farmacéutica que lo comprende, método para su preparación, y uso de estos
CO2022008616A2 (es) Composición farmacéutica oral que comprende compuesto de carbamato y método de preparación para la misma
CO2019013254A2 (es) Compuestos bicíclicos 5,6-fusionados y composiciones para el tratamiento de enfermedades parasitarias
CL2018000430A1 (es) Compuesto de hidroxitriazina y uso médico relacionado.
PE20181450A1 (es) Compuestos de 1,3,4-tiadiazol y su uso en el tratamiento del cancer
MY197042A (en) Compounds
UY37166A (es) Nucleósidos ánalogos de alquinilo como inhibidores de rinovirus humano
BR112022016124A2 (pt) Composto de di-hidronaftiridinona, e método de preparação para este e uso médico deste