CU20110134A7 - Inhibidores de la metaloproteinasa matriz - Google Patents

Inhibidores de la metaloproteinasa matriz

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Publication number
CU20110134A7
CU20110134A7 CU20110134A CU20110134A CU20110134A7 CU 20110134 A7 CU20110134 A7 CU 20110134A7 CU 20110134 A CU20110134 A CU 20110134A CU 20110134 A CU20110134 A CU 20110134A CU 20110134 A7 CU20110134 A7 CU 20110134A7
Authority
CU
Cuba
Prior art keywords
compounds
present
hyper
carboxylic acids
inhibitors
Prior art date
Application number
CU20110134A
Other languages
English (en)
Inventor
Sunanda G Dastidar
Manoj Kumar Khera
Venkata P Palle
Viswajanani Jitendra Sattigeri
Punit Kumar Srivastava
Arpita Musib
Sony Joseph
Abdul Rehman Abdul Rauf
Ajay Soni
Manoj Kumar Tiwari
Ranadheer Reddy
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of CU20110134A7 publication Critical patent/CU20110134A7/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
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    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

El presente invento se relaciona con procesos para la síntesis de ácidos carboxílicos beta-hidroxi- y amino-sustituidos, que actúan como inhibidores de la metaloproteasa matriz, especialmente ácidos carboxílicos beta-hidroxidiastereoméricamente puros, y composiciones farmacéuticas que contienen los compuestos del presente invento. Los compuestos del presente invento son útiles en el tratamiento de diversas enfermedades inflamatorias, de autoinmunidad y alérgicas, como ser los métodos para tratar el asma, la artritis reumatoidea, COPD, rinitis, osteoartritis, artritis soriásica, psoriasis, fibrosis pulmonar, desórdenes en la cura de heridas, inflamación pulmonar, síndrome de perturbación respiratoria agudo, periodontitis, esclerosis múltiple, gingivitis, ateroesclerosis, proliferación neoíntima, que lleva a la restenosis y a la insuficiencia cardíaca isquémica, ataque apopléjico, enfermedades renales, metástasis tumoral y otros desórdenes inflamatorios caracterizados por la hiper-expresión e hiper-activación de una metaloproteinasa matriz utilizando los compuestos.
CU20110134A 2006-08-22 2011-06-15 Inhibidores de la metaloproteinasa matriz CU20110134A7 (es)

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