CS272267B1 - Crystalline form of a 1-benzydril-4-aryl--piperazindyhydrochloride and process for preparing thereof - Google Patents
Crystalline form of a 1-benzydril-4-aryl--piperazindyhydrochloride and process for preparing thereof Download PDFInfo
- Publication number
- CS272267B1 CS272267B1 CS859879A CS987985A CS272267B1 CS 272267 B1 CS272267 B1 CS 272267B1 CS 859879 A CS859879 A CS 859879A CS 987985 A CS987985 A CS 987985A CS 272267 B1 CS272267 B1 CS 272267B1
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- crystalline form
- φορμη
- benzhydryl
- band
- ratio
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000002441 X-ray diffraction Methods 0.000 claims abstract description 3
- 238000002329 infrared spectrum Methods 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 4
- -1 allyl halide Chemical class 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000009833 condensation Methods 0.000 claims description 2
- 230000005494 condensation Effects 0.000 claims description 2
- NWVNXDKZIQLBNM-UHFFFAOYSA-N diphenylmethylpiperazine Chemical compound C1CNCCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 NWVNXDKZIQLBNM-UHFFFAOYSA-N 0.000 claims description 2
- 230000020477 pH reduction Effects 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims description 2
- 230000002950 deficient Effects 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 abstract description 2
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 238000009877 rendering Methods 0.000 abstract 1
- 101000820460 Homo sapiens Stomatin Proteins 0.000 description 2
- 102100021685 Stomatin Human genes 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 229910020679 Co—K Inorganic materials 0.000 description 1
- 241001669680 Dormitator maculatus Species 0.000 description 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
- 240000006909 Tilia x europaea Species 0.000 description 1
- 108091029474 Y RNA Proteins 0.000 description 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 101150115538 nero gene Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BG8468185A BG41728A1 (en) | 1984-12-28 | 1984-12-28 | Crystal form of 1- benzhydryl- 4- adyl- piperazine dihydrochloride and method for its preparation |
| DD85285574A DD264821A3 (de) | 1984-12-28 | 1985-12-30 | Kristalline form "a" des benzhydryl-4-allyl-piperazin-dihydrogenchlorids und verfahren zu ihrer herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS987985A1 CS987985A1 (en) | 1988-10-14 |
| CS272267B1 true CS272267B1 (en) | 1991-01-15 |
Family
ID=25663335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS859879A CS272267B1 (en) | 1984-12-28 | 1985-12-27 | Crystalline form of a 1-benzydril-4-aryl--piperazindyhydrochloride and process for preparing thereof |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0189679B1 (da) |
| JP (1) | JPS61225176A (da) |
| BG (1) | BG41728A1 (da) |
| CS (1) | CS272267B1 (da) |
| DD (1) | DD264821A3 (da) |
| DK (1) | DK608985A (da) |
| FI (1) | FI82457C (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4792553A (en) * | 1986-02-04 | 1988-12-20 | Terumo Kabushiki Kaisha | Diene derivatives and vasodilators containing the same |
| US6130221A (en) | 1997-03-05 | 2000-10-10 | Nymox Corporation | Pharmaceutical agents that impede the initiation and progression of primary and secondary DMS disruptions |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES514340A0 (es) * | 1982-06-17 | 1983-09-01 | Ferrer Int | "procedimiento de obtencion de nuevos derivados de piperazina". |
-
1984
- 1984-12-28 BG BG8468185A patent/BG41728A1/xx unknown
-
1985
- 1985-12-23 FI FI855147A patent/FI82457C/fi not_active IP Right Cessation
- 1985-12-27 CS CS859879A patent/CS272267B1/cs unknown
- 1985-12-27 JP JP60299706A patent/JPS61225176A/ja active Pending
- 1985-12-30 DK DK608985A patent/DK608985A/da not_active Application Discontinuation
- 1985-12-30 EP EP85309531A patent/EP0189679B1/en not_active Expired - Lifetime
- 1985-12-30 DD DD85285574A patent/DD264821A3/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0189679B1 (en) | 1990-06-13 |
| DK608985D0 (da) | 1985-12-30 |
| FI82457C (fi) | 1991-03-11 |
| FI855147A0 (fi) | 1985-12-23 |
| DK608985A (da) | 1986-06-29 |
| BG41728A1 (en) | 1987-08-14 |
| JPS61225176A (ja) | 1986-10-06 |
| FI855147A7 (fi) | 1986-06-29 |
| EP0189679A1 (en) | 1986-08-06 |
| CS987985A1 (en) | 1988-10-14 |
| DD264821A3 (de) | 1989-02-15 |
| FI82457B (fi) | 1990-11-30 |
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