CS270249B2 - Method of purine's new derivatives production - Google Patents

Method of purine's new derivatives production Download PDF

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Publication number
CS270249B2
CS270249B2 CS887057A CS705788A CS270249B2 CS 270249 B2 CS270249 B2 CS 270249B2 CS 887057 A CS887057 A CS 887057A CS 705788 A CS705788 A CS 705788A CS 270249 B2 CS270249 B2 CS 270249B2
Authority
CS
Czechoslovakia
Prior art keywords
purine
formula
fluoro
amino
threopentofuranosyl
Prior art date
Application number
CS887057A
Other languages
Czech (cs)
English (en)
Other versions
CS705788A2 (en
Inventor
Robert W Lambert
Joseph A Martin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878725466A external-priority patent/GB8725466D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CS705788A2 publication Critical patent/CS705788A2/cs
Publication of CS270249B2 publication Critical patent/CS270249B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CS887057A 1987-10-30 1988-10-25 Method of purine's new derivatives production CS270249B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878725466A GB8725466D0 (en) 1987-10-30 1987-10-30 Purine derivatives
GB888816612A GB8816612D0 (en) 1987-10-30 1988-06-13 Purine derivatives

Publications (2)

Publication Number Publication Date
CS705788A2 CS705788A2 (en) 1989-10-13
CS270249B2 true CS270249B2 (en) 1990-06-13

Family

ID=26292971

Family Applications (1)

Application Number Title Priority Date Filing Date
CS887057A CS270249B2 (en) 1987-10-30 1988-10-25 Method of purine's new derivatives production

Country Status (15)

Country Link
EP (1) EP0314011A3 (no)
JP (1) JPH01149797A (no)
CN (1) CN1038102A (no)
AU (1) AU2416088A (no)
CS (1) CS270249B2 (no)
DK (1) DK603788A (no)
FI (1) FI884954A7 (no)
HU (1) HU199502B (no)
IL (1) IL88138A0 (no)
MC (1) MC1984A1 (no)
NO (1) NO168037C (no)
NZ (1) NZ226672A (no)
PH (1) PH25577A (no)
PT (1) PT88891B (no)
YU (1) YU199688A (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310732A (en) * 1986-02-03 1994-05-10 The Scripps Research Institute 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
US5106837A (en) * 1988-03-16 1992-04-21 The Scripps Research Institute Adenosine derivatives with therapeutic activity
US4908440A (en) * 1987-11-12 1990-03-13 Bristol Myers Company 2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides
US4997926A (en) * 1987-11-18 1991-03-05 Scripps Clinic And Research Foundation Deaminase-stable anti-retroviral 2-halo-2',3'-dideoxy
WO1989008658A1 (en) * 1988-03-16 1989-09-21 Scripps Clinic And Research Foundation Substituted adenine derivatives useful as therapeutic agents
GR1000618B (el) * 1989-03-17 1992-08-31 Oncogen Μεθοδος αναστολης hiv χρησιμοποιωντας συνεργιστικους συνδυασμους νουκλεοσιδικων παραγωγων.
US5034518A (en) * 1989-05-23 1991-07-23 Southern Research Institute 2-fluoro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine nucleosides
US5384310A (en) * 1989-05-23 1995-01-24 Southern Research Institute 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
AU2001238516B2 (en) * 2000-02-18 2005-08-04 Southern Research Institute Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H- purin-6-amine
US6753322B2 (en) 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
US7528247B2 (en) 2001-08-02 2009-05-05 Genzyme Corporation Process for preparing purine nucleosides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340645C (en) * 1987-04-17 1999-07-13 Victor E. Marquez Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus

Also Published As

Publication number Publication date
NO168037B (no) 1991-09-30
FI884954A0 (fi) 1988-10-27
IL88138A0 (en) 1989-06-30
EP0314011A3 (de) 1990-04-11
NZ226672A (en) 1991-07-26
NO884830L (no) 1989-05-02
EP0314011A2 (de) 1989-05-03
AU2416088A (en) 1989-05-04
PT88891B (pt) 1993-01-29
DK603788A (da) 1989-05-01
CS705788A2 (en) 1989-10-13
HU199502B (en) 1990-02-28
NO168037C (no) 1992-01-08
PH25577A (en) 1991-08-08
DK603788D0 (da) 1988-10-28
JPH01149797A (ja) 1989-06-12
MC1984A1 (fr) 1989-11-23
YU199688A (en) 1990-04-30
NO884830D0 (no) 1988-10-28
CN1038102A (zh) 1989-12-20
HUT48270A (en) 1989-05-29
FI884954A7 (fi) 1989-05-01

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