CS258490B2 - Method of ergoline's new 2-substituted derivatives production - Google Patents

Method of ergoline's new 2-substituted derivatives production Download PDF

Info

Publication number
CS258490B2
CS258490B2 CS867155A CS715586A CS258490B2 CS 258490 B2 CS258490 B2 CS 258490B2 CS 867155 A CS867155 A CS 867155A CS 715586 A CS715586 A CS 715586A CS 258490 B2 CS258490 B2 CS 258490B2
Authority
CS
Czechoslovakia
Prior art keywords
alpha
carbon
methyl
ergolinyl
diethylurea
Prior art date
Application number
CS867155A
Other languages
Czech (cs)
English (en)
Other versions
CS715586A2 (en
Inventor
Andreas Huth
Gerhard Sauer
Helmut Wachtel
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Priority to CS872684A priority Critical patent/CS258497B2/cs
Publication of CS715586A2 publication Critical patent/CS715586A2/cs
Publication of CS258490B2 publication Critical patent/CS258490B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CS867155A 1985-10-04 1986-10-03 Method of ergoline's new 2-substituted derivatives production CS258490B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS872684A CS258497B2 (cs) 1985-10-04 1987-04-15 Způsob výroby nových 2-substituovaných derivátů ergolinu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853535930 DE3535930A1 (de) 1985-10-04 1985-10-04 Neue 2-substituierte ergolinderivate

Publications (2)

Publication Number Publication Date
CS715586A2 CS715586A2 (en) 1987-12-17
CS258490B2 true CS258490B2 (en) 1988-08-16

Family

ID=6283086

Family Applications (1)

Application Number Title Priority Date Filing Date
CS867155A CS258490B2 (en) 1985-10-04 1986-10-03 Method of ergoline's new 2-substituted derivatives production

Country Status (5)

Country Link
US (1) US4826851A (ja)
EP (1) EP0217735A3 (ja)
JP (1) JPS62174074A (ja)
CS (1) CS258490B2 (ja)
DE (1) DE3535930A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
DE3824659A1 (de) * 1988-07-15 1990-02-08 Schering Ag 2-, 12- oder 13-substituierte 3-(8'(alpha)-ergolinyl)-1,1-diethylharnstoffe, ihre herstellung und verwendung in arzneimitteln
US5229129A (en) * 1989-07-12 1993-07-20 Cygnus Therapeutic Systems Transdermal administration of lisuride
US5252335A (en) * 1989-07-12 1993-10-12 Cygnus Therapeutic Systems Transdermal administration of lisuride

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3251846A (en) * 1966-05-17 G-dimethyosoergolenyl-b
US3029243A (en) * 1960-06-20 1962-04-10 Miles Lab Preparation of dihydroagroclavine from a mixture of agroclavine and elymoclavine
SE393615B (sv) * 1971-05-19 1977-05-16 Sandoz Ag Forfarande for framstellning av 6-metyl-8 beta-ureidometyl-ergolener
CH573936A5 (ja) * 1971-08-05 1976-03-31 Spofa Vereinigte Pharma Werke
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
GB2112382B (en) * 1981-11-06 1985-03-06 Erba Farmitalia Ergoline derivatives
DE3309493A1 (de) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
DE3413659A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 2-substituierte ergolin-derivate
DE3587860D1 (de) * 1984-04-09 1994-07-28 Schering Ag 2-substituierte Ergolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
DE3413657A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergoline

Also Published As

Publication number Publication date
JPS62174074A (ja) 1987-07-30
DE3535930A1 (de) 1987-04-09
EP0217735A2 (de) 1987-04-08
US4826851A (en) 1989-05-02
EP0217735A3 (en) 1989-03-29
CS715586A2 (en) 1987-12-17

Similar Documents

Publication Publication Date Title
EP0082808B1 (en) Novel ergolinyl compounds nitrogen-substituted in the 8-position, their preparation, and use as medicinal agents
US4731367A (en) 2-substituted ergolines useful as neuroleptics and antidepressants
CS259893B2 (en) Method of ergoline's 1,2-disubstituted derivatives production
CS258490B2 (en) Method of ergoline's new 2-substituted derivatives production
US3968111A (en) 8,8-Disubstituted-6-methylergolines and related compounds
CS248739B2 (en) Production method of the new 2-substituted derivatives of ergoline
EP0220129B1 (de) 12- und 13-substituierte Ergolinderivate
US4740509A (en) 12- and 13-bromoergolines useful for treating hypertension
CA1289947C (en) 1-alkyl ergolinylthiourea derivatives, process for the preparation thereof, as well as their use as medicinal agents
CS259898B2 (en) Method of ergoline's new 1,2-disubstituted derivatives production
CS247100B2 (en) Production method of 2-(trialkylsilyl)-ergoline
USRE30218E (en) 8,8-Disubstituted-6-methylergolines and related compounds
USRE30219E (en) Method of preparing 8,8-disubstituted-6-methylergolines and related compounds
CS258497B2 (cs) Způsob výroby nových 2-substituovaných derivátů ergolinu
IE41475B1 (en) Improvements in or relating to ergolene derivatives
HUT58093A (en) Process for producing 2,13-disubstituted ergolines and pharmaceutical compositions comprising same