CS244610B1 - Domestoc animals grovth stimulators - Google Patents

Abstract

The object of the invention is the use of an acid diacetyl and their esters in a chain of 1 to 3 carbon atoms, as a stimulator the growth of the economic unfold that as additives to biofactor supplements or feed.

Description

»44610 2 The subject matter of the invention is the growth promoters of livestock with the diacetyl acid group. In the course of fattening farms, specifically active compounds are used which increase the weight gain by wetting and at the same time improve feed utilization. These substances also have an antibacterial effect, which is reflected in the improved overall fattened state of health and in their death. At present, synthetic substances are used in the fattening of poultry derivatives of 5-nitro-furan, in particular nitrovin, and in the fattening of pigs, rearing piglets, rearing and fattening calves, quinexaline 1,4-dioxide, carbadox and olaquindex.

However, their disadvantage is the mutagenic activity which is very high in 5-nitrofuran and some quinexaline-1,4-dioxide derivatives. The more stimulating effects are diacetylic acid, 3- (3,4-diacetoxyphenyl) propanoic acid and its esters of formula 1

CH3COO

CH OCOCHj

CH-COOR 10 wherein H is hydrogen or alkyl of 1 to 3 carbon atoms in the chain.

These compounds increase their weight gains and improve nutrient utilization when applied to poultry, piglets, pigs, calves, fish and other types of farms. Additions of 10 to 200 mg / kg of feed dry matter or complete feed mixture result in a significant increase in weight gain of 15%, with feed utilization improving at 10%.

They have the advantage over 5-nitrofuran and quinexaline 1,4-dioxide derivatives that they are not mutagenic. They did not show mutagenic activity in the Ames tests even during metabolic activation. While chlnoxaline-1,4-dlexide induces 3 reversal / nmol of the substance and 3- (2-chloro-xalynylmethylene) methylcarbazate-N, N-dioxide 90 roverzl / nmol, it was found in diacetylic acid and its methyl, ethyl and propyl esters found 0.0 reverse / nmol.

Similar to coffee acid and its esters, which are naturally distributed in natural material and are also parts of some propolis species (Cižmárik, J., Vatel, I .: Bxperientia26, 713 (1970), Moftsner, J. et al .: Pharmasie 34, 97 (1979), Schnoidevind, E.-U. et al., Pharmasie 34, 103, (1979), have diacetylcalaic acid and its esters antimicrobial activity and are effective against various strains of B. coli and Staph aureus.

Said compounds are added to the supplements of the biofactors or premium feed additives or complete feed mixtures.

Biofactor Depth: Diacetylclavic Acid Vitamin A

Vitamin Dj

Vitamin Bg

Vitamin

Vitamin 5 000 mg 000 000 IU 100 000 IU 300 mg 2 mg 200 mg

Claims (3)

3 244610 Niacin Methienine Sulphate Sulphate Anhydrous Honenzine (C ^ HH ^O), Na) Premix 10% Kurasan (6-ethexy-2,2,4-trimethyl- • 1,2-dihydroquinoline) 2 Blafactar Bacteria: Methyl diacetylcalate ester Vitauain A Vitamin Dg Bitamin Bg Vitamin C Vitamin Bg Vitamin B Vitamin Niacin Calcium Pantothenate Lysine Hydrochloride Kurasan Wheat Flour ad Example 3 Premix: Methyl diacetylcalate Feed ad flour ad Premix is applied to the dry matter of the feed 1 200 mg 25 000 mg 250,000 mg 100,000 mg 12,500 mg 1 kg 7,500 mg 800,000 IU 200,000 IU 300 mg 10,000 mg 100 mg 3,000 mg 150 mg 1,000 mg 500 mg 50,000 mg 12,500 mg 1 kg 5,000 mg 1 kg complete feed mixture at 1 kg. 100 kg '' Example 4 Premix: Diacetylcylic acid pre-ester 5 000 mg Feeding flour 1 kg Premix is applied to the dry matter of the feed or complete feed mixture at 1 kg. BACKGROUND OF THE INVENTION Use of diacetylclavic acid and its esters of formula 1 CH = CH-COOR Wherein R is hydrogen or alkyl of 1 to 3 carbon atoms in the chain as growth promoters of farm animals, particularly as additives to biofactors or feed supplements.