CS239217B1 - Unguent base of water-oil type emulsion - Google Patents

Abstract

Water / oil emulsion ointment base which is intended for therapeutic and / or cosmetic use purposes. Except for common fat and hydrophilic components contain aluminum stearate and zinc; by changing their quantity can be to change the properties of the foundation within wide limits, especially consistency, from milky to to pasty. Other essential ingredients are beeswax, sodium tetraborate and an emulsifier having a hydrophilic-lipophilic value equilibria of 4 to 5, in particular fatty esters acids with glycerol and sorbitol.

Description

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Water / oil emulsion ointment base

An ointment base of a water / oil emulsion for medical and / or cosmetic purposes. In addition to conventional fatty and hydrophilic ingredients, it contains aluminum and zinc stearate; by varying the amount thereof, the properties of the base, in particular the consistency, can be varied within a wide range from milky to pasty. Other essential ingredients are beeswax, sodium tetraborate and an emulsifier with a hydrophilic-lipophilic balance of 4-5, especially of the fatty acid esters of glycerol and sorbitol.

239 217

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The present invention relates to a butter base of the water / oil emulsion type for use in cosmetic and / or cosmetic purposes; if desired, the composition of this base can be adapted, for example, from the form of a paste to the form of liquid milk. This deficiency is more pronounced in the preparations of the type of mildew milk. There are a large number of patients who need a greasy emulsion base to repair dry skin, which provides the skin with the lack of fat «

When developing the optimum composition of the butter / water / oil emulsion base, it is necessary to select a formulation that provides the desired physical, chemical and pharmacological properties. It is especially the requirement of emulsion system stability, its rheological parameters, spreadability, absorbability and dermal irritability ·

The problem of building a high-quality water / oil emulsion base has been addressed by experts for a long time. This type of base is technologically more demanding than emulsions of the opposite type, ie oil / water. This is mainly due to the fact that suitable emulsifiers with a low hydrophilic-lipophilic balance value are not available in too large a selection, so that the choice of a suitable raw material is more difficult to achieve the effect. Therefore, in some cases, water / oil / oily emulsion creams are inhibited by preparations based on an ambitious water / oil / water emulsion containing an increased amount of fat phase.

Water / oil emulsion products are suitable for ease of application, convenient appearance, consistency, packaging and price.

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The properties of the foundations of this type depend on the properties of all components and the technological process. For example, the washability of the emulsions was investigated using different bases and a new apparatus (B.Fecak, J.Kucera, Food Industry 9, 283, 1970). 92, 65, 67, 1966], the issue of fatty emulsions is discussed (ESIower, Seifen,

Ole, Fette, Wachse 99, 16, 1973] and discussed theories of this type of emulsions and emulsifiers with particular reference to sorbitan monostearate. The use of water / oil emulsions including the recipes / W.Heers, Seifen, Ole, Fette, Wachse 101/3 /, 71 has also been described »

British Patent No. 1,128,170 protects the preparation of non-toxic and non-irritating water / oil emulsions containing oleic acid monoglyceride and 30-70% aqueous sorbitol, optionally with up to 16% propylene glycol. No. 173,983 addresses the recipe and mixed-emulsion technology into which a significant amount of aqueous and fat phases can be incorporated. The emulsion has a greasy character, although its outer phase is aqueous.

Further advances in this field are the water-in-oil emulsion base, based on a grease component containing vaseline and / or beeswax and a hydrophilic component containing water and / or propylene glycol and / or ethanol, with the addition of an emulsifier, stabilizer and / or preservative. substances according to the invention. It consists of 0.2 to 1.0% by weight, preferably 0.4 to 0.7% by weight. of aluminum stearate, 0.05 to 0.90, preferably 0.10 to 0.40 wt. zinc stearate, 2.0 to 5.0, preferably 3.0 to 4.0 wt. 0.5 to 1.0, preferably 0.6 to 0.8 wt.% sodium tetraborate and 3.0 to 6.0, preferably 4.0 to 5.0 wt. a physiologically harmless emulsifier with a hydrophilic-lipophilic balance value of 4 to 5, especially of the fatty acid esters of glycerol and sorbitol ·

The butter base according to the invention has been constructed on the basis of long-term research into suitable recipe and technology. It represents a greasy emulsion base of a distinct water / oil type, with favorable rheological properties, optimal stability and dermal

- 3 239 217 compatibility. Parts of this foundation are proven raw materials, which have long been used in pharmacy and cosmetics.

The basic ingredients which influence the consistency of the emulsion to be prepared are zinc and aluminum stearate and their ratio. Higher aluminum stearate content ensures a thin / milky / consistency and stability. The increased content of zinc stearate, on the other hand, gives the emulsion a thicker, pasty consistency. By varying the relative proportions of these 3-sheets, the properties of the finished product can be varied within wide limits, greatly expanding application possibilities.

Sodium tetraborate serves as a buffer, stabilizer, physiologically acceptable alkalinizing agent for neutralizing the free fatty acids optionally contained in the fat composition (beeswax, lanolin, etc.) in the ointment base of the invention.

A suitable physiologically acceptable emulsifier with a low hydrophilic lipophilic balance, preferably 4 to 5, for example based on fatty acid esters of glycerol and sorbitol, facilitates perfect dispersion of both phases and allows further hydrophilic and / or lipophilic to be incorporated into the emulsion as desired. especially active ingredients. The ointment base according to the invention, by itself, without the addition of any active ingredients, serves as an inert dermatological agent, especially intended for pediatric practice.

Great variability of physicochemical properties, without any limitation or deterioration of application, tolerability, resorpoe, washability or subjective feelings in the user, represents the most important benefit of the field of external products *

The ointment base according to the invention complies with the prescribed tests according to both the pharmacopoeia and the standards in force. Clinical testing on a representative group of people confirmed good tolerability, non-irritability and expected efficacy *

The following examples illustrate several application possibilities of the ointment base according to the invention, without however exhausting all the possibilities.

Example

Example

Example

Cream for children

Paraffin oil 20,00 Paraffin solid 5.00 Beeswax 3.00 Zinc stearate 0.30 Aluminum stearate 0.30 Sodium tetraborate 0.60 Zinc oxide 8.00 Emulsifier 4.00 Perfume 0.50 Konzervans 0.20 Water 58.10

Baby cream II

Paraffin oil 20,00 Paraffin solid 6.00 Vaselina bílá 6.95 Beeswax 3.00 Zinc stearate 0.05 Aluminum stearate 0.60 Sodium tetraborate 0.60 Emulsifier 4.00 Perfume 0.50 Konzervans 0.20 Water 58.10

Oily corticosteroid cream

Paraffin oil 20,00 Paraffin solid 5.00 Beeswax 3.00 Zinc stearate 0.60 Aluminum stearate 0.40 Sodium tetraborate 0.60

239 217 = - 5 Emulsifier 4.00 Hydrocortisone acetate 0.10 Preservative 0.20 Water 66.10

Example 4 Acne Cream

Vaeelina white 25.00 Beeswax 3.00 Zinc stearate 0.40 Aluminum stearate 0.40 Sodium tetraborate 0.60 Emulsifier 4.00 Salicylic acid 0.50 Colloidal sulfur 2.00 Preservative 0.20 Water 63.90

Example 5 Glycerin Hand Cream

Paraffin oil 15,00 Solid paraffin 5,00 Beeswax 4,00 Lanolin 5,00 Glycerin 10,00 Zinc stearate 0,30 Aluminum stearate 0,50 Sodium tetraborate 0,80 Emulsifier 5,00 Preservative 0,15 Water 54,25

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Example 6 Sunscreen

Paraffin oil 23,00 Paraffin solid 5,00 Beeswax 3,00 Zinc stearate 0,40 Aluminum stearate 0,40 Sodium tetraborate 0,60 Emulsifier 5,00 Alpha-naphthylcetyl ether 5,00 Theophylline 2,00 Propylene glycol 5,00 Perfume 0.60 Preservative 0.22 Water 50.78

Example 7 Azulene cream

Vaseline white 23,00 Beeswax 3,00 Zinc stearate 0,50 Aluminum stearate 0,30 Sodium tetraborate 0,60 Emulsifier 4,00 Azulene 0,20 Preservatives 0,20 Water 68,20

Example 8 Oily skin lotion

Paraffin oil 24,00 Beeswax 3,00 Zinc stearate 0,05 Aluminum stearate 0,60 Sodium tetraborate 0,60 Emulsifier 4,00

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- 7 Bthanol 5.00

Perfume 0.40

Konzervans 0,20

Water 62.15

Example 9 Scabies milk

Paraffin oil 26,00

Beeswax 3.00

Zinc stearate 0,10

Aluminum stearate 0.60

Sodium tetraborate 0.60

Emulsifier 4.00 gamma-Isomer hexaohloroyclohexane 1.00

Konzervans 0,10

Water 64.60

Example 10 Massage Milk

Paraffin oil 22,00

Beeswax 3.00

Zinc stearate 0.05

Aluminum stearate 0.60

Sodium tetraborate 0.60

Emulsifier 4.00

Ethanol 5,00

Menthol 0.50

Methyl salicylate 0.30

Mustard oil 0,001

Camphor 1.00

Konzervans 0,20

Water 62,749

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In the preparation of the verbal formulations mentioned in the preceding examples, it is generally understood that the tubular phase / paraffin oil, solid paraffin, beeswax, vaseline, lanolin and the like are first melted and sterilized. at 130 ° C for 30 min. At 110 ° C, zinc stearate and aluminum stearate are dissolved, and at 90 ° C an emulsifier is added to the mixture, which also dissolves. An aqueous phase consisting of sterilized distilled or demineralized water, in which sodium tetraborate, a preservative, etc. is dissolved, is added at a temperature of 65 to 75 ° C. After this, the emulsification, which takes place in a suitable homogenization boiler, is cooled to 40 DEG C. while stirring. ° 0. At this temperature, the active ingredients and perfume are added to the emulsion and the resulting mixture is cooled to room temperature (about 20 ° C) with gentle stirring and filled.

The baby creams prepared according to Examples 1 and 2 (Neridetta) were subjected to clinical trials. Cream testing was performed in 63 patients of the dermatology clinic with the diagnosis of eczema-dermatitis. The creams were very well suited for the intended purpose, they did not cause any signs of intolerance, even on specially available terrain.

Claims (6)

P Sed M Ž T 7 tnI m υ 239 217 1 · Butter base of the water / oil emulsion base, a fatty component containing liquid and / or paraffin and / or vaseline and / or beeswax and a hydrophilic component containing water and / or propylene glycol and / or ethanol, with the addition of an emulsifier, % stabilizer and / or preservative, characterized in that it contains 0.2 to 1.0 wt. aluminum stearate, 0.05 to 0.90 wt.% zinc stearate, 2.0 to 5.0 wt. beeswax, 0.5 to 1.0% by weight · sodium tetraborate and 3.0 to 6.0% by weight · physiologically harmless emulsifier with a hydrophilic lipophilic balance value of 4 to 5 »especially of the fatty acid esters of glycerol and sorbitol · The butter base according to item 1 preferably comprises 0.4 to 0.7% by weight. 3. The butter base according to claim 1, preferably 0.1 to 0.4% by weight. The butter base according to item 1 preferably comprises 3.0 to 40% by weight. The butter base according to item 1 preferably comprises 0.6 to 0.8% by weight. The butter base according to claim 1, preferably having from 4.0 to 5.0% by weight of an emulsifier, characterized in that the aluminum obsastearate is characterized in that the zinc obsastearate is characterized in that it is characterized in that The composition of claim 1, characterized in that it is obsafysiologically harmless