CS238400B2 - N-(2-pyridyl)-2-methyl-4-hydroxy-2h-1,2-benzothizine-3-carboxamide-1,1-dioxide production method - Google Patents

N-(2-pyridyl)-2-methyl-4-hydroxy-2h-1,2-benzothizine-3-carboxamide-1,1-dioxide production method Download PDF

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Publication number
CS238400B2
CS238400B2 CS841363A CS136384A CS238400B2 CS 238400 B2 CS238400 B2 CS 238400B2 CS 841363 A CS841363 A CS 841363A CS 136384 A CS136384 A CS 136384A CS 238400 B2 CS238400 B2 CS 238400B2
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Czechoslovakia
Prior art keywords
hydroxy
methyl
pyridyl
carboxamide
formula
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CS841363A
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Czech (cs)
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CS136384A2 (en
Inventor
Boris Sket
Pavel Zupet
Marko Zupan
Marjeta Globokar
Miha Japelj
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Krka Tovarna Zdravil
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Publication of CS136384A2 publication Critical patent/CS136384A2/en
Publication of CS238400B2 publication Critical patent/CS238400B2/en

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Abstract

Předmětem vynálezu je nový způsob výroby N- (2-pyridyl J -2-methyl-4-hydroxy-2Htak, že se uvede v reakci sloučenina obecného vzorce II s 2-aminopyridin-l-N-oxidem v inertním rozpouštědle. Sloučenina vzorce I je známý protizánětlivý prostředek nesteroidní povahy a mimoto má analgetický a antipyretický účinek.It is an object of the present invention to provide a novel process N- (2-pyridyl-2-methyl-4-hydroxy-2H-tert, that a general compound is reacted of formula II with 2-aminopyridine-1-N-oxide in an inert solvent. The compound of formula I is known to be anti-inflammatory a non-steroidal agent, and moreover has an analgesic and antipyretic effect.

Description

Předmětem vynálezu je nový způsob výroby N- (2-pyridyl) -2-methyl-4-hydroxy-2H-The present invention provides a novel process for the preparation of N- (2-pyridyl) -2-methyl-4-hydroxy-2H-

tak, že se uvede v reakci sloučenina obecného vzorce IIby reacting a compound of formula II

s 2-aminopyridin-l-N-oxidem v inertním rozpouštědle.with 2-aminopyridine-1-N-oxide in an inert solvent.

Sloučenina vzorce I je známý protizánětlivý prostředek nesteroidní povahy a mimoto má analgetický a antipyretický účinek.The compound of formula I is a known anti-inflammatory agent of non-steroidal nature and, moreover, has an analgesic and antipyretic effect.

238460 <«238460 <«

Tutéž sloučeninu je možno získat rovněž analogickým způsobem tak, že se užije jako výchozí látka sloučenina obecného vzor-The same compound can also be obtained in an analogous manner, starting from a compound of the formula (I).

Claims (3)

PREDMETSUBJECT 1. Způsob výroby N-(2-pyridylj-2-methyl-4-hydroxy-2H-l,2-benzothiazin-3-karboxamid-l,l-dioxidu vzorce I ce II, v němž R znamená ethyl, propyl nebo terc.butyl.A process for the preparation of N- (2-pyridyl) -2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide of formula (II) wherein R is ethyl, propyl or tert-butylamine. .butyl. vyznačující se tím, že se uvede v reakci alkyl- ( 4-hy dr oxy-2-methyl-2H-l,2-benzothiazin-3-karboxylát)-l,l-dioxid obecného vzorce II kdecharacterized by reacting in the reaction the alkyl (4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate) -1,1-dioxide of the formula II wherein: R znamená alkylový zbytek o 1 až 4 atomech uhlíku, s 2-aminopyridin-l-N-oxidem vzorce III v inertním organickém rozpouštědle.R represents an alkyl radical of 1 to 4 carbon atoms, with a 2-aminopyridine-1-N-oxide of formula III in an inert organic solvent. 2. Způsob podle bodu 1, vyznačující se tím, že se jako inertního organického rozpouštědla užije xylenu.2. The process according to claim 1, wherein xylene is used as the inert organic solvent. 3. Způsob podle bodů 1 a 2, vyznačující se tím, že se amidace provádí při teplotě varu reakční směsi pod zpětným chladičem.3. The process according to claim 1, wherein the amidation is carried out at the reflux temperature of the reaction mixture.
CS841363A 1983-07-08 1984-02-27 N-(2-pyridyl)-2-methyl-4-hydroxy-2h-1,2-benzothizine-3-carboxamide-1,1-dioxide production method CS238400B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU148283A YU42871B (en) 1983-07-08 1983-07-08 Process for the manufacture of n-(2-pyridyl)-2-methyl-4-hydroxy-2h-1,2-benzothiazine-3-carboxamide-1,1-dioxide

Publications (2)

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CS136384A2 CS136384A2 (en) 1984-12-14
CS238400B2 true CS238400B2 (en) 1985-11-13

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CS841363A CS238400B2 (en) 1983-07-08 1984-02-27 N-(2-pyridyl)-2-methyl-4-hydroxy-2h-1,2-benzothizine-3-carboxamide-1,1-dioxide production method

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CS (1) CS238400B2 (en)
YU (1) YU42871B (en)

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YU148283A (en) 1985-12-31
CS136384A2 (en) 1984-12-14
YU42871B (en) 1988-12-31

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