CS228512B2 - Method for the production of new makrolide - Google Patents

Method for the production of new makrolide Download PDF

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Publication number
CS228512B2
CS228512B2 CS815397A CS539781A CS228512B2 CS 228512 B2 CS228512 B2 CS 228512B2 CS 815397 A CS815397 A CS 815397A CS 539781 A CS539781 A CS 539781A CS 228512 B2 CS228512 B2 CS 228512B2
Authority
CS
Czechoslovakia
Prior art keywords
domm
dihydro
doml
medium
esters
Prior art date
Application number
CS815397A
Other languages
Czech (cs)
English (en)
Inventor
Richard H Baltz
Gene M Wild
Eugene T Seno
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS228512B2 publication Critical patent/CS228512B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/54—Streptomyces fradiae

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
CS815397A 1980-07-24 1981-07-14 Method for the production of new makrolide CS228512B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8024211 1980-07-24

Publications (1)

Publication Number Publication Date
CS228512B2 true CS228512B2 (en) 1984-05-14

Family

ID=10514997

Family Applications (1)

Application Number Title Priority Date Filing Date
CS815397A CS228512B2 (en) 1980-07-24 1981-07-14 Method for the production of new makrolide

Country Status (23)

Country Link
EP (1) EP0045157B1 (xx)
JP (1) JPS5750998A (xx)
KR (1) KR840001193B1 (xx)
AR (1) AR227325A1 (xx)
AU (1) AU7286281A (xx)
CA (1) CA1174994A (xx)
CS (1) CS228512B2 (xx)
DD (1) DD202452A5 (xx)
DE (1) DE3163204D1 (xx)
DK (1) DK313081A (xx)
ES (1) ES503957A0 (xx)
FI (1) FI812209L (xx)
GB (1) GB2080798B (xx)
GR (1) GR74509B (xx)
HU (1) HU189519B (xx)
IE (1) IE51619B1 (xx)
IL (1) IL63312A (xx)
PH (1) PH18089A (xx)
PL (1) PL232190A1 (xx)
PT (1) PT73370B (xx)
RO (1) RO81671B (xx)
YU (1) YU173981A (xx)
ZA (1) ZA814789B (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411892A (en) * 1982-05-03 1983-10-25 Pfizer Inc. Tylosin macrolide antibiotics from streptomyces
US4443436A (en) * 1982-09-13 1984-04-17 Eli Lilly And Company C-20-Modified macrolide derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, and lactenocin
US4820694A (en) * 1986-09-29 1989-04-11 Eli Lilly And Company Modifications of 3-O-demethylmycinose in macrocin and lactenocin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201843A (en) * 1975-08-01 1980-05-06 Sanraku Ocean Co., Ltd. Process for manufacturing tylosin derivatives

Also Published As

Publication number Publication date
PT73370B (en) 1982-08-09
DD202452A5 (de) 1983-09-14
CA1174994A (en) 1984-09-25
GR74509B (xx) 1984-06-29
PL232190A1 (xx) 1982-03-29
IL63312A (en) 1985-04-30
IL63312A0 (en) 1981-10-30
AR227325A1 (es) 1982-10-15
YU173981A (en) 1983-09-30
JPS5750998A (en) 1982-03-25
IE51619B1 (en) 1987-01-21
IE811581L (en) 1982-01-24
ZA814789B (en) 1983-02-23
GB2080798A (en) 1982-02-10
PT73370A (en) 1981-08-01
DK313081A (da) 1982-01-25
HU189519B (en) 1986-07-28
EP0045157B1 (en) 1984-04-18
KR840001193B1 (ko) 1984-08-18
FI812209L (fi) 1982-01-25
PH18089A (en) 1985-03-20
ES8206622A1 (es) 1982-05-16
DE3163204D1 (en) 1984-05-24
RO81671B (ro) 1983-04-30
RO81671A (ro) 1983-04-29
ES503957A0 (es) 1982-05-16
EP0045157A1 (en) 1982-02-03
GB2080798B (en) 1984-07-25
AU7286281A (en) 1982-01-28

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