CS214792B2 - Method of making the dimeric compounds of indol-dihydroindole derivatives genus vinca connected by the bridge - Google Patents
Method of making the dimeric compounds of indol-dihydroindole derivatives genus vinca connected by the bridge Download PDFInfo
- Publication number
- CS214792B2 CS214792B2 CS793284A CS328479A CS214792B2 CS 214792 B2 CS214792 B2 CS 214792B2 CS 793284 A CS793284 A CS 793284A CS 328479 A CS328479 A CS 328479A CS 214792 B2 CS214792 B2 CS 214792B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- vlb
- deacetyl
- bis
- formula
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS806477A CS214794B2 (cs) | 1978-05-15 | 1980-09-25 | Způsob výroby poloamidů dimerních indol-dihydroindolových derivátů z rodu Vinca, spojených můstkem |
CS806476A CS214793B2 (en) | 1978-05-15 | 1980-09-25 | New method of making the dimeric disulphides of indol-dihydroindole derivatives genus vinca connected by the bridge |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/905,667 US4199504A (en) | 1978-05-15 | 1978-05-15 | Bridged cathranthus alkaloid dimers |
Publications (1)
Publication Number | Publication Date |
---|---|
CS214792B2 true CS214792B2 (en) | 1982-05-28 |
Family
ID=25421234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS793284A CS214792B2 (en) | 1978-05-15 | 1979-05-14 | Method of making the dimeric compounds of indol-dihydroindole derivatives genus vinca connected by the bridge |
Country Status (21)
Country | Link |
---|---|
US (1) | US4199504A (fr) |
EP (3) | EP0033981A3 (fr) |
JP (1) | JPS54148798A (fr) |
AU (1) | AU4691379A (fr) |
BE (1) | BE876155A (fr) |
CA (1) | CA1114816A (fr) |
CS (1) | CS214792B2 (fr) |
DD (3) | DD147543A5 (fr) |
DK (1) | DK197579A (fr) |
ES (3) | ES480560A1 (fr) |
FI (1) | FI791519A (fr) |
FR (2) | FR2435480A1 (fr) |
GB (1) | GB2022080A (fr) |
GR (1) | GR73047B (fr) |
IL (1) | IL57434A0 (fr) |
LU (1) | LU81254A1 (fr) |
PH (3) | PH14999A (fr) |
PL (2) | PL215593A1 (fr) |
PT (1) | PT69589A (fr) |
RO (1) | RO81682B (fr) |
ZA (1) | ZA792271B (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4362664A (en) * | 1980-12-29 | 1982-12-07 | Eli Lilly And Company | Vinblastine oxazolidinedione disulfides and related compounds |
DK167984A (da) * | 1983-03-30 | 1984-10-01 | Lilly Industries Ltd | Alkaloidderivater |
WO2000006582A1 (fr) * | 1998-07-31 | 2000-02-10 | Goldsmith Seeds, Inc. | Alcaloides trimeres et polymeres |
WO2001024763A2 (fr) | 1999-10-01 | 2001-04-12 | Immunogen, Inc. | Compositions et methodes de traitement du cancer utilisant des immunoconjugues et des agents chimiotherapeutiques |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR204004A1 (es) * | 1973-04-02 | 1975-11-12 | Lilly Co Eli | Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina |
IL48685A (en) * | 1975-01-09 | 1980-03-31 | Lilly Co Eli | Amides of vincadioline and vinblastine |
GR69783B (fr) * | 1976-09-08 | 1982-07-07 | Lilly Co Eli | |
US4115388A (en) * | 1977-03-30 | 1978-09-19 | Eli Lilly And Company | 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds |
HU181874B (en) * | 1977-08-08 | 1983-11-28 | Lilly Co Eli | Process for preparing amides of deacetyl-leurosine and deacetyl-leuroformine |
-
1978
- 1978-05-15 US US05/905,667 patent/US4199504A/en not_active Expired - Lifetime
-
1979
- 1979-05-05 PH PH22464A patent/PH14999A/en unknown
- 1979-05-08 PT PT69589A patent/PT69589A/pt unknown
- 1979-05-09 AU AU46913/79A patent/AU4691379A/en not_active Abandoned
- 1979-05-10 ZA ZA792271A patent/ZA792271B/xx unknown
- 1979-05-10 BE BE1/9386A patent/BE876155A/fr unknown
- 1979-05-10 FR FR7911882A patent/FR2435480A1/fr active Pending
- 1979-05-10 CA CA327,351A patent/CA1114816A/fr not_active Expired
- 1979-05-11 FI FI791519A patent/FI791519A/fi not_active Application Discontinuation
- 1979-05-12 GR GR59071A patent/GR73047B/el unknown
- 1979-05-14 GB GB7916702A patent/GB2022080A/en not_active Withdrawn
- 1979-05-14 JP JP5962979A patent/JPS54148798A/ja active Pending
- 1979-05-14 ES ES480560A patent/ES480560A1/es not_active Expired
- 1979-05-14 EP EP81101924A patent/EP0033981A3/fr not_active Withdrawn
- 1979-05-14 DK DK197579A patent/DK197579A/da unknown
- 1979-05-14 RO RO97514A patent/RO81682B/ro unknown
- 1979-05-14 ES ES480562A patent/ES480562A1/es not_active Expired
- 1979-05-14 ES ES480561A patent/ES480561A1/es not_active Expired
- 1979-05-14 EP EP79300826A patent/EP0005620A1/fr not_active Withdrawn
- 1979-05-14 CS CS793284A patent/CS214792B2/cs unknown
- 1979-05-14 EP EP81101927A patent/EP0032756A3/fr not_active Withdrawn
- 1979-05-14 LU LU81254A patent/LU81254A1/fr unknown
- 1979-05-15 DD DD79217285A patent/DD147543A5/de unknown
- 1979-05-15 DD DD79217286A patent/DD150467A5/de unknown
- 1979-05-15 PL PL21559379A patent/PL215593A1/xx unknown
- 1979-05-15 DD DD79212894A patent/DD143618A5/de unknown
- 1979-05-15 PL PL1979222094A patent/PL120896B1/pl unknown
- 1979-05-30 IL IL57434A patent/IL57434A0/xx unknown
- 1979-10-31 FR FR7926971A patent/FR2438052A1/fr active Pending
-
1980
- 1980-03-06 PH PH23731A patent/PH14904A/en unknown
- 1980-03-06 PH PH23730A patent/PH14907A/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL222094A1 (fr) | 1980-10-20 |
EP0005620A1 (fr) | 1979-11-28 |
EP0033981A2 (fr) | 1981-08-19 |
RO81682A (fr) | 1983-04-29 |
FR2438052A1 (fr) | 1980-04-30 |
PT69589A (en) | 1979-06-01 |
EP0033981A3 (fr) | 1981-09-09 |
PH14907A (en) | 1982-01-29 |
PL215593A1 (fr) | 1980-06-16 |
PL120896B1 (en) | 1982-03-31 |
AU4691379A (en) | 1979-11-22 |
EP0032756A2 (fr) | 1981-07-29 |
IL57434A0 (en) | 1979-09-30 |
PH14999A (en) | 1982-03-22 |
BE876155A (fr) | 1979-11-12 |
ZA792271B (en) | 1980-12-31 |
ES480562A1 (es) | 1980-04-01 |
FI791519A (fi) | 1979-11-16 |
DD150467A5 (de) | 1981-09-02 |
PH14904A (en) | 1982-01-29 |
DD143618A5 (de) | 1980-09-03 |
FR2435480A1 (fr) | 1980-04-04 |
CA1114816A (fr) | 1981-12-22 |
DD147543A5 (de) | 1981-04-08 |
GR73047B (fr) | 1984-01-26 |
US4199504A (en) | 1980-04-22 |
RO81682B (ro) | 1983-04-30 |
ES480560A1 (es) | 1980-04-01 |
ES480561A1 (es) | 1980-04-01 |
EP0032756A3 (fr) | 1981-09-09 |
LU81254A1 (fr) | 1979-09-10 |
DK197579A (da) | 1979-11-16 |
GB2022080A (en) | 1979-12-12 |
JPS54148798A (en) | 1979-11-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CS218585B2 (en) | Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine | |
HU185261B (en) | Process for preparing n-/vinblastinoyl-23/-derivatives of some aminoacids and peptides | |
DK141511B (da) | Analogifremgangsmåde til fremstilling af derivater af vindblastin, leurosidin eller leurocristin. | |
CS214792B2 (en) | Method of making the dimeric compounds of indol-dihydroindole derivatives genus vinca connected by the bridge | |
CA1285567C (fr) | Derives bisulfures de pyrroloindole | |
EP2119720A1 (fr) | Nouveaux dérivées de la vinblastine, leur préparation, et compositions pharmaceutiques les comprenant. | |
CA1082179A (fr) | Amides derives du vlb, de la leurosidine, de la leurocristine et d'autres alcaloides dimeres | |
ES2336010T3 (es) | Derivados de n-desacetiltiocolchicina, su uso y formulaciones farmaceuticas que los contienen. | |
Hirata et al. | Potential CNS antitumor agents—phenothiazines I: Nitrogen mustard derivatives | |
KR840002164B1 (ko) | 빈카로이코블라스틴 유도체의 제조방법 | |
GB2196006A (en) | Preparation of mitomycin derivatives | |
CA1121815A (fr) | Dimeres d'alcaloide de catharantus pontes | |
CS214793B2 (en) | New method of making the dimeric disulphides of indol-dihydroindole derivatives genus vinca connected by the bridge | |
GB2111055A (en) | M-(Vinblastinoyl-23) derivatives of amino acids | |
HU180724B (en) | Process for producing vinblastine-3-spiro-5-comma above-comma above-oxazolidine-2-comma above-comma above,4-comma above-comma above-dione | |
JPS62195384A (ja) | 新規なカンプトテシン誘導体 | |
KR810001453B1 (ko) | 인돌-디하이드로인돌 카복스 아마이드 이량체의 제조방법 | |
CA1127153A (fr) | Dimeres pontes d'alcaloide de catharantus | |
KR820001240B1 (ko) | 4-데스 아세틸 vlb c-3카복스하이드라지드의 항종양 유도체 제조방법 | |
US6765015B2 (en) | Halogenated paclitaxel derivatives | |
KR790000810B1 (ko) | 빈브라스틴 유도체의 제조방법 | |
KR820001241B1 (ko) | 4-데스아세틸 vlb c-3카복스하이드라지드의 항종양유도체 제조방법 | |
Ukrainets et al. | 4-Hydroxy-2-quinolones 6. Synthesis, chemical transformations, and biological properties of dialkylamino-, hydroxy-, and halodialkylamides of 4-hydroxy-2-quinolone-3-carboxylic acids | |
NL8304017A (nl) | Bleomycine-derivaten; werkwijze voor het bereiden daarvan; farmaceutisch preparaat met antitumor eigenschappen. | |
PL94203B1 (fr) |