CS203080B2 - Method of preparing the imping agent against the influenza,containing the weakened h3 n2 strain of inflenza virus - Google Patents
Method of preparing the imping agent against the influenza,containing the weakened h3 n2 strain of inflenza virus Download PDFInfo
- Publication number
- CS203080B2 CS203080B2 CS746552A CS655274A CS203080B2 CS 203080 B2 CS203080 B2 CS 203080B2 CS 746552 A CS746552 A CS 746552A CS 655274 A CS655274 A CS 655274A CS 203080 B2 CS203080 B2 CS 203080B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- serum
- strain
- influenza
- virus
- influenza virus
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 16
- 241000700605 Viruses Species 0.000 title claims description 43
- 206010022000 influenza Diseases 0.000 title description 6
- 210000002966 serum Anatomy 0.000 claims abstract description 64
- 241000712461 unidentified influenza virus Species 0.000 claims abstract description 48
- 239000003112 inhibitor Substances 0.000 claims abstract description 36
- 238000010790 dilution Methods 0.000 claims abstract description 19
- 239000012895 dilution Substances 0.000 claims abstract description 19
- 229960003971 influenza vaccine Drugs 0.000 claims abstract description 16
- 235000013601 eggs Nutrition 0.000 claims abstract description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 7
- 241000700199 Cavia porcellus Species 0.000 claims description 11
- 230000003612 virological effect Effects 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 210000001161 mammalian embryo Anatomy 0.000 claims description 4
- 244000052616 bacterial pathogen Species 0.000 claims description 3
- 241000700198 Cavia Species 0.000 claims description 2
- 230000000644 propagated effect Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 abstract description 19
- 241000287828 Gallus gallus Species 0.000 abstract description 14
- 239000000203 mixture Substances 0.000 abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 4
- 239000008024 pharmaceutical diluent Substances 0.000 abstract description 2
- 238000007865 diluting Methods 0.000 abstract 1
- 239000007923 nasal drop Substances 0.000 abstract 1
- 229940100662 nasal drops Drugs 0.000 abstract 1
- 239000007922 nasal spray Substances 0.000 abstract 1
- 229940097496 nasal spray Drugs 0.000 abstract 1
- 210000002257 embryonic structure Anatomy 0.000 description 14
- 241000283073 Equus caballus Species 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 238000011081 inoculation Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 241000282339 Mustela Species 0.000 description 6
- 230000035931 haemagglutination Effects 0.000 description 6
- 239000002054 inoculum Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000001888 Peptone Substances 0.000 description 5
- 108010080698 Peptones Proteins 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 235000019319 peptone Nutrition 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000002255 vaccination Methods 0.000 description 4
- 244000309464 bull Species 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229960001226 live attenuated influenza Drugs 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 238000005215 recombination Methods 0.000 description 3
- 230000006798 recombination Effects 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 241000271566 Aves Species 0.000 description 2
- 239000003708 ampul Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 229940099472 immunoglobulin a Drugs 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 241000371980 Influenza B virus (B/Shanghai/361/2002) Species 0.000 description 1
- 229940124873 Influenza virus vaccine Drugs 0.000 description 1
- 206010028735 Nasal congestion Diseases 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 229940031551 inactivated vaccine Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000037797 influenza A Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/401,335 US3953592A (en) | 1973-09-27 | 1973-09-27 | Live influenza virus vaccines and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS203080B2 true CS203080B2 (en) | 1981-02-27 |
Family
ID=23587327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS746552A CS203080B2 (en) | 1973-09-27 | 1974-09-24 | Method of preparing the imping agent against the influenza,containing the weakened h3 n2 strain of inflenza virus |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US3953592A (de) |
| JP (1) | JPS5058223A (de) |
| AT (1) | AT331978B (de) |
| BE (1) | BE819865A (de) |
| CA (1) | CA1030450A (de) |
| CH (1) | CH595447A5 (de) |
| CS (1) | CS203080B2 (de) |
| DD (1) | DD114966A5 (de) |
| DE (1) | DE2445819A1 (de) |
| DK (1) | DK508274A (de) |
| ES (1) | ES430415A1 (de) |
| FI (1) | FI278774A (de) |
| FR (1) | FR2245376B1 (de) |
| GB (1) | GB1461188A (de) |
| HU (1) | HU169383B (de) |
| IE (1) | IE40180B1 (de) |
| IL (1) | IL45589A (de) |
| LU (1) | LU70998A1 (de) |
| NL (1) | NL7411746A (de) |
| NO (1) | NO743433L (de) |
| SE (1) | SE429405B (de) |
| ZA (1) | ZA745571B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6042209B2 (ja) * | 1974-05-31 | 1985-09-20 | 北里研究所（社団法人） | インフルエンザウイルスの新鮮分離株を発育鶏卵へ短期間で順化させる方法 |
| US4318903A (en) * | 1978-07-12 | 1982-03-09 | Smithkline-Rit | Live influenza virus vaccine and the preparation thereof |
| US4278662A (en) * | 1979-10-16 | 1981-07-14 | Smith Kline - Rit | Attenuated influenza type A virus vaccine |
| JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
| US4783411A (en) * | 1984-10-22 | 1988-11-08 | Janis Gabliks | Influenza-A virus vaccine from fish cell cultures |
| NZ224422A (en) * | 1987-05-05 | 1990-11-27 | Molecular Eng Ass | Composition adapted for intranasal immunisation against viral infection comprising a glycoprotein complexed with a lipid |
| US7678087B2 (en) * | 1999-09-29 | 2010-03-16 | Heska Corporation | Equine intranasal delivery system |
| US6398774B1 (en) | 1999-09-29 | 2002-06-04 | Heska Corporation | Intranasal delivery system |
| ES2784189T3 (es) | 2009-03-27 | 2020-09-23 | Academia Sinica | Métodos y composiciones para la inmunización contra virus |
| TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
-
1973
- 1973-09-27 US US05/401,335 patent/US3953592A/en not_active Expired - Lifetime
-
1974
- 1974-08-28 CH CH1173374A patent/CH595447A5/xx not_active IP Right Cessation
- 1974-08-29 CA CA208,125A patent/CA1030450A/en not_active Expired
- 1974-08-30 ZA ZA00745571A patent/ZA745571B/xx unknown
- 1974-09-04 IL IL45589A patent/IL45589A/en unknown
- 1974-09-04 NL NL7411746A patent/NL7411746A/xx not_active Application Discontinuation
- 1974-09-13 FR FR7431029A patent/FR2245376B1/fr not_active Expired
- 1974-09-13 BE BE148474A patent/BE819865A/xx not_active IP Right Cessation
- 1974-09-21 JP JP49109440A patent/JPS5058223A/ja active Pending
- 1974-09-24 CS CS746552A patent/CS203080B2/cs unknown
- 1974-09-24 NO NO743433A patent/NO743433L/no unknown
- 1974-09-25 LU LU70998A patent/LU70998A1/xx unknown
- 1974-09-25 FI FI2787/74A patent/FI278774A/fi unknown
- 1974-09-25 DE DE19742445819 patent/DE2445819A1/de not_active Ceased
- 1974-09-26 GB GB4184974A patent/GB1461188A/en not_active Expired
- 1974-09-26 AT AT776074A patent/AT331978B/de active
- 1974-09-26 HU HURE565A patent/HU169383B/hu unknown
- 1974-09-26 DD DD181344A patent/DD114966A5/xx unknown
- 1974-09-26 IE IE1994/74A patent/IE40180B1/xx unknown
- 1974-09-26 DK DK508274A patent/DK508274A/da unknown
- 1974-09-26 SE SE7412113A patent/SE429405B/sv unknown
- 1974-09-26 ES ES430415A patent/ES430415A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH595447A5 (de) | 1978-02-15 |
| LU70998A1 (de) | 1975-03-06 |
| SE7412113L (de) | 1975-04-01 |
| AT331978B (de) | 1976-09-10 |
| SE429405B (sv) | 1983-09-05 |
| US3953592A (en) | 1976-04-27 |
| ZA745571B (en) | 1975-09-24 |
| IE40180B1 (en) | 1979-03-28 |
| ATA776074A (de) | 1975-12-15 |
| BE819865A (fr) | 1975-03-13 |
| ES430415A1 (es) | 1977-02-01 |
| FR2245376A1 (de) | 1975-04-25 |
| JPS5058223A (de) | 1975-05-21 |
| FI278774A (de) | 1975-03-28 |
| DK508274A (de) | 1975-06-02 |
| CA1030450A (en) | 1978-05-02 |
| DE2445819A1 (de) | 1975-04-10 |
| GB1461188A (en) | 1977-01-13 |
| DD114966A5 (de) | 1975-09-05 |
| HU169383B (de) | 1976-11-28 |
| AU7330674A (en) | 1976-03-18 |
| NL7411746A (nl) | 1975-04-02 |
| IL45589A0 (en) | 1974-11-29 |
| IE40180L (en) | 1975-03-27 |
| IL45589A (en) | 1977-05-31 |
| FR2245376B1 (de) | 1978-07-28 |
| NO743433L (de) | 1975-04-28 |
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