CS192504B2 - Method of producing cyano-methyl-thioacetyl-cephalosporins - Google Patents

Method of producing cyano-methyl-thioacetyl-cephalosporins

Info

Publication number
CS192504B2
CS192504B2 CS735525A CS552573A CS192504B2 CS 192504 B2 CS192504 B2 CS 192504B2 CS 735525 A CS735525 A CS 735525A CS 552573 A CS552573 A CS 552573A CS 192504 B2 CS192504 B2 CS 192504B2
Authority
CS
Czechoslovakia
Prior art keywords
thioacetyl
cephalosporins
methyl
producing cyano
cyano
Prior art date
Application number
CS735525A
Other languages
Czech (cs)
English (en)
Inventor
Hermann Breuer
Uwe Treuner
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Priority to CS771590A priority Critical patent/CS192529B2/cs
Publication of CS192504B2 publication Critical patent/CS192504B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CS735525A 1972-08-04 1973-08-03 Method of producing cyano-methyl-thioacetyl-cephalosporins CS192504B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS771590A CS192529B2 (en) 1972-08-04 1977-03-09 Method of preparing derivatives of 2-//cyanomethyl/thio/-acetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00278168A US3855212A (en) 1972-08-04 1972-08-04 Cyanomethylth ioacetylcephalosporins

Publications (1)

Publication Number Publication Date
CS192504B2 true CS192504B2 (en) 1979-08-31

Family

ID=23063949

Family Applications (1)

Application Number Title Priority Date Filing Date
CS735525A CS192504B2 (en) 1972-08-04 1973-08-03 Method of producing cyano-methyl-thioacetyl-cephalosporins

Country Status (19)

Country Link
US (1) US3855212A (fr)
JP (2) JPS5953273B2 (fr)
AR (1) AR203371A1 (fr)
AT (1) AT328078B (fr)
BE (1) BE803199A (fr)
CA (1) CA1088518A (fr)
CH (2) CH587239A5 (fr)
CS (1) CS192504B2 (fr)
DD (1) DD107698A5 (fr)
DE (2) DE2336655A1 (fr)
ES (1) ES417555A1 (fr)
FR (1) FR2194417B1 (fr)
GB (2) GB1437221A (fr)
HU (2) HU167055B (fr)
IE (1) IE39002B1 (fr)
NL (1) NL7310751A (fr)
PH (1) PH9246A (fr)
SU (1) SU886747A3 (fr)
ZA (1) ZA734512B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932397A (en) * 1972-08-04 1976-01-13 E. R. Squibb & Sons, Inc. Cyanomethylthioacetylcephalosporins
US3944546A (en) * 1972-08-04 1976-03-16 E. R. Squibb & Sons, Inc. Cyanomethylthioacetylcephalosporins
US3932396A (en) * 1972-08-04 1976-01-13 E. R. Squibb & Sons, Inc. Cyanomethylthioacetylcephalosporins
US3963709A (en) * 1973-08-17 1976-06-15 Smithkline Corporation Cyanomethyl sulfinyl- and sulfonyl-acetamido cephalosporins
US3963711A (en) * 1973-08-17 1976-06-15 Smithkline Corporation Cyanomethyl sulfinyl- and sulfonyl-acetamido cephalosporins
US3985746A (en) * 1975-03-25 1976-10-12 E. R. Squibb & Sons, Inc. 7-(α-Cyanomethylthio)acetamido-3-cephem carboxylates
GB8715925D0 (en) * 1987-07-07 1987-08-12 Shell Int Research Thiapentanamide derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR902398A (fr) * 1942-12-22 1945-08-29 Carlo Wedekind & Co Installation d'évaporation perfectionnée à thermo-compression
FR1321704A (fr) * 1962-04-03 1963-03-22 Lilly Co Eli Procédé pour préparer des dérivés 7-(mercapto-acylamido s-substitués) des céphalosporines c et nouveaux composés ainsi préparés
CH480365A (de) * 1965-01-18 1969-10-31 Ciba Geigy Verfahren zur Herstellung neuer Derivate der 7-Aminocephalosporansäure
US3530123A (en) * 1966-11-02 1970-09-22 Fujisawa Pharmaceutical Co 3-thiolated-7-sydnone-acylamino-cephalosporanic acid derivatives
CH527215A (de) 1967-04-15 1972-08-31 Fujisawa Pharmaceutical Co Verfahren zur Herstellung von 3,7-disubstituierten Cephalosporinderivaten
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds

Also Published As

Publication number Publication date
GB1437221A (en) 1976-05-26
HU167055B (fr) 1975-07-28
IE39002L (en) 1974-02-04
AR203371A1 (es) 1975-09-08
ES417555A1 (es) 1976-03-01
FR2194417B1 (fr) 1978-07-28
CA1088518A (fr) 1980-10-28
DE2366461C2 (fr) 1988-03-31
JPS50105680A (fr) 1975-08-20
JPS56115766A (en) 1981-09-11
GB1437222A (en) 1976-05-26
AT328078B (de) 1976-03-10
BE803199A (fr) 1974-02-04
US3855212A (en) 1974-12-17
CH580107A5 (fr) 1976-09-30
DE2336655A1 (de) 1974-02-28
SU886747A3 (ru) 1981-11-30
IE39002B1 (en) 1978-07-19
FR2194417A1 (fr) 1974-03-01
ATA689473A (de) 1975-05-15
CH587239A5 (fr) 1977-04-29
HU166316B (fr) 1975-02-28
AU5763673A (en) 1975-01-09
ZA734512B (en) 1974-06-26
JPS5953273B2 (ja) 1984-12-24
PH9246A (en) 1975-07-30
JPS595580B2 (ja) 1984-02-06
NL7310751A (fr) 1974-02-06
DD107698A5 (fr) 1974-08-12

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