CS189689B2 - Method for the production and stabilisation of anhydroussalt of 7-/d-2-formyloxy-2-phenylacetamido/-3-/1-methyl-1h tetrazol -5-ylthiomethyl/-3-cephem-4-carboxylic acid - Google Patents

Method for the production and stabilisation of anhydroussalt of 7-/d-2-formyloxy-2-phenylacetamido/-3-/1-methyl-1h tetrazol -5-ylthiomethyl/-3-cephem-4-carboxylic acid

Info

Publication number
CS189689B2
CS189689B2 CS751158A CS115875A CS189689B2 CS 189689 B2 CS189689 B2 CS 189689B2 CS 751158 A CS751158 A CS 751158A CS 115875 A CS115875 A CS 115875A CS 189689 B2 CS189689 B2 CS 189689B2
Authority
CS
Czechoslovakia
Prior art keywords
anhydroussalt
ylthiomethyl
phenylacetamido
cephem
formyloxy
Prior art date
Application number
CS751158A
Other languages
Czech (cs)
English (en)
Inventor
Joseph M Indelicato
James M Greene
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23765656&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS189689(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS189689B2 publication Critical patent/CS189689B2/cs

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CS751158A 1974-02-22 1975-02-21 Method for the production and stabilisation of anhydroussalt of 7-/d-2-formyloxy-2-phenylacetamido/-3-/1-methyl-1h tetrazol -5-ylthiomethyl/-3-cephem-4-carboxylic acid CS189689B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US444622A US3928592A (en) 1974-02-22 1974-02-22 Antibiotic pharmaceutical compositions

Publications (1)

Publication Number Publication Date
CS189689B2 true CS189689B2 (en) 1979-04-30

Family

ID=23765656

Family Applications (1)

Application Number Title Priority Date Filing Date
CS751158A CS189689B2 (en) 1974-02-22 1975-02-21 Method for the production and stabilisation of anhydroussalt of 7-/d-2-formyloxy-2-phenylacetamido/-3-/1-methyl-1h tetrazol -5-ylthiomethyl/-3-cephem-4-carboxylic acid

Country Status (24)

Country Link
US (1) US3928592A (xx)
JP (1) JPS6119605B2 (xx)
AR (1) AR203895A1 (xx)
AT (1) AT356264B (xx)
BE (1) BE825653A (xx)
CA (1) CA1043261A (xx)
CH (1) CH620929A5 (xx)
CS (1) CS189689B2 (xx)
DD (1) DD117807A5 (xx)
DE (1) DE2506622C2 (xx)
DK (1) DK153919C (xx)
ES (1) ES434976A1 (xx)
FR (1) FR2261772B1 (xx)
GB (1) GB1493676A (xx)
HU (1) HU174129B (xx)
IE (1) IE40671B1 (xx)
IL (1) IL46650A (xx)
NL (1) NL179976C (xx)
PH (1) PH12058A (xx)
PL (1) PL109311B1 (xx)
SE (1) SE406153B (xx)
SU (1) SU659094A3 (xx)
YU (1) YU41875A (xx)
ZA (1) ZA75975B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054738A (en) * 1975-12-22 1977-10-18 Eli Lilly And Company Sodium cefamandole crystalline forms
JPS5283956A (en) * 1976-01-01 1977-07-13 Lilly Co Eli Antibiotic method and medical composition
JPS5329936A (en) * 1976-08-31 1978-03-20 Takeda Chem Ind Ltd Antibiotic composition
JPS5711909A (en) * 1980-06-23 1982-01-21 Shionogi & Co Ltd Stable freeze-dried preparation of beta-lactam
IL93618A0 (en) * 1989-03-06 1990-12-23 Lilly Co Eli Improved diluent formulation for daptomycin
JP4873207B2 (ja) * 2001-02-26 2012-02-08 東レ・ファインケミカル株式会社 光学活性カルボン酸クロリドの精製方法
CN100554271C (zh) * 2007-07-27 2009-10-28 苏州中联化学制药有限公司 抗菌素头孢孟多酯钠的合成方法
CN101880290B (zh) * 2010-06-28 2012-03-07 海南新中正制药有限公司 头孢孟多酯钠的制备方法
WO2013057197A1 (en) * 2011-10-20 2013-04-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the formylation of cefamandole
WO2013057196A1 (en) * 2011-10-20 2013-04-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of cefamandole nafate
US9834567B1 (en) * 2014-12-16 2017-12-05 Tianjin University Crystalline form of cefamandole nafate compound, preparation and preparing method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1767891C3 (de) * 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds

Also Published As

Publication number Publication date
CA1043261A (en) 1978-11-28
HU174129B (hu) 1979-11-28
PH12058A (en) 1978-10-18
DD117807A5 (xx) 1976-02-05
JPS6119605B2 (xx) 1986-05-17
DK153919C (da) 1989-02-06
DK153919B (da) 1988-09-26
SU659094A3 (ru) 1979-04-25
ES434976A1 (es) 1976-12-16
DE2506622C2 (de) 1987-02-26
NL7502045A (nl) 1975-08-26
AR203895A1 (es) 1975-10-31
IE40671L (en) 1975-08-22
NL179976B (nl) 1986-07-16
FR2261772A1 (xx) 1975-09-19
AT356264B (de) 1980-04-25
YU41875A (en) 1982-05-31
SE7501985L (xx) 1975-08-25
SE406153B (sv) 1979-01-29
PL109311B1 (en) 1980-05-31
NL179976C (nl) 1986-12-16
AU7833975A (en) 1976-08-19
JPS50126817A (xx) 1975-10-06
IE40671B1 (en) 1979-07-18
US3928592A (en) 1975-12-23
BE825653A (fr) 1975-08-18
FR2261772B1 (xx) 1980-01-04
DE2506622A1 (de) 1975-08-28
CH620929A5 (xx) 1980-12-31
DK65575A (xx) 1975-10-20
GB1493676A (en) 1977-11-30
IL46650A0 (en) 1975-05-22
ATA128475A (de) 1979-09-15
IL46650A (en) 1977-10-31
ZA75975B (en) 1976-09-29

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