CS180047B2 - Method for production of novel prostaglandins - Google Patents

Method for production of novel prostaglandins

Info

Publication number
CS180047B2
CS180047B2 CS7600000453A CS45376A CS180047B2 CS 180047 B2 CS180047 B2 CS 180047B2 CS 7600000453 A CS7600000453 A CS 7600000453A CS 45376 A CS45376 A CS 45376A CS 180047 B2 CS180047 B2 CS 180047B2
Authority
CS
Czechoslovakia
Prior art keywords
production
novel prostaglandins
prostaglandins
novel
Prior art date
Application number
CS7600000453A
Other languages
English (en)
Inventor
Isidoros Vlattas
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of CS180047B2 publication Critical patent/CS180047B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/46—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings substituted on the ring sulfur atom
    • C07D333/48—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings substituted on the ring sulfur atom by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS7600000453A 1973-05-18 1974-05-16 Method for production of novel prostaglandins CS180047B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US361752A US3881017A (en) 1973-05-18 1973-05-18 9-Thiaprostaglandin compositions

Publications (1)

Publication Number Publication Date
CS180047B2 true CS180047B2 (en) 1977-12-30

Family

ID=23423319

Family Applications (4)

Application Number Title Priority Date Filing Date
CS7600000453A CS180047B2 (en) 1973-05-18 1974-05-16 Method for production of novel prostaglandins
CS7600000452A CS180046B2 (en) 1973-05-18 1974-05-16 Method for production of novel prostaglandins
CS7400003513A CS180011B2 (en) 1973-05-18 1974-05-16 Method for production of novel thiaproetaglandins
CS7600000454A CS180048B2 (en) 1973-05-18 1974-05-16 Method for production of novel thiaprostaglandins

Family Applications After (3)

Application Number Title Priority Date Filing Date
CS7600000452A CS180046B2 (en) 1973-05-18 1974-05-16 Method for production of novel prostaglandins
CS7400003513A CS180011B2 (en) 1973-05-18 1974-05-16 Method for production of novel thiaproetaglandins
CS7600000454A CS180048B2 (en) 1973-05-18 1974-05-16 Method for production of novel thiaprostaglandins

Country Status (11)

Country Link
US (1) US3881017A (cs)
AR (5) AR207448A1 (cs)
CS (4) CS180047B2 (cs)
ES (1) ES426425A1 (cs)
FI (1) FI149274A7 (cs)
HU (1) HU172465B (cs)
IE (1) IE39573B1 (cs)
IL (1) IL44770A (cs)
MC (1) MC1018A1 (cs)
PL (2) PL98130B1 (cs)
ZA (2) ZA742445B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018802A (en) * 1975-04-09 1977-04-19 Merck & Co., Inc. 9-Thia- and oxothia- and 9-dioxothia-11,12-seco-prostaglandins and processes
US4130566A (en) * 1977-10-27 1978-12-19 Sumitomo Chemical Company, Limited Process for producing 5-carboxy-2-acetylthiophene
US4291166A (en) * 1978-03-13 1981-09-22 Research Corporation Pharmaceutically active 6,9-thiaprostacyclin analogs and derivatives thereof
US4258199A (en) * 1978-03-13 1981-03-24 Research Corporation Method for preparing cyclic ethers and thioethers including oxygen isomers and sulfur analogs of prostacyclin
US4256878A (en) * 1978-05-11 1981-03-17 Hoffmann-La Roche Inc. Polyene compounds
US4230872A (en) * 1978-05-11 1980-10-28 Hoffmann-La Roche Inc. Polyene compounds
US5371096A (en) * 1993-08-27 1994-12-06 Ciba-Geigy Corporation (3-pyridyl)tetrafuran-2-yl substituted carboxylic acids
AU2003280977B2 (en) * 2002-07-12 2008-10-23 Fumie Sato Prostaglandin derivatives
ES2442901T3 (es) 2007-04-18 2014-02-14 Cornerstone Pharmaceuticals, Inc. Derivados de ácido lipoico
MX2009011165A (es) 2007-04-18 2009-12-09 Cornerstone Pharmaceuticals In Formulaciones farmaceuticas que contienen derivados del acido lipoico.
US8263653B2 (en) 2007-04-18 2012-09-11 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives
EP3189033B1 (en) 2014-06-19 2020-08-05 Rafael Pharmaceuticals, Inc. Pharmaceutical compounds
ES2747702T3 (es) 2014-06-19 2020-03-11 Rafael Pharmaceuticals Inc Compuestos farmacéuticos

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3691202A (en) * 1968-10-25 1972-09-12 Ici Ltd Phenyl-thienyl- and phenyl-furyl malonic acid derivatives

Also Published As

Publication number Publication date
ZA742445B (en) 1975-05-28
IE39573B1 (en) 1978-11-08
IE39573L (en) 1974-11-18
PL98958B1 (pl) 1978-06-30
AR205275A1 (es) 1976-04-21
AR209769A1 (es) 1977-05-31
AR205464A1 (es) 1976-05-07
IL44770A0 (en) 1974-07-31
MC1018A1 (fr) 1975-02-28
IL44770A (en) 1977-10-31
ZA743150B (en) 1975-05-28
US3881017A (en) 1975-04-29
HU172465B (hu) 1978-09-28
CS180048B2 (en) 1977-12-30
FI149274A7 (cs) 1974-11-19
PL98130B1 (pl) 1978-04-29
CS180046B2 (en) 1977-12-30
ES426425A1 (es) 1976-07-01
CS180011B2 (en) 1977-12-30
AR207448A1 (es) 1976-10-08
AR208350A1 (es) 1976-12-20

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