CS126491A3 - Polymeric mixture, process for its preparation and a pharmaceutical containing said mixture - Google Patents

Polymeric mixture, process for its preparation and a pharmaceutical containing said mixture Download PDF

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Publication number
CS126491A3
CS126491A3 CS911264A CS126491A CS126491A3 CS 126491 A3 CS126491 A3 CS 126491A3 CS 911264 A CS911264 A CS 911264A CS 126491 A CS126491 A CS 126491A CS 126491 A3 CS126491 A3 CS 126491A3
Authority
CS
Czechoslovakia
Prior art keywords
group
poles
polymers
composition
poly
Prior art date
Application number
CS911264A
Other languages
Czech (cs)
English (en)
Inventor
Robert Lee Albright
Original Assignee
Rohm & Haas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/681,032 external-priority patent/US5300288A/en
Application filed by Rohm & Haas filed Critical Rohm & Haas
Publication of CS126491A3 publication Critical patent/CS126491A3/cs

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/765Polymers containing oxygen
    • A61K31/78Polymers containing oxygen of acrylic acid or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/52Amides or imides
    • C08F20/54Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F20/60Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/785Polymers containing nitrogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/795Polymers containing sulfur
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
CS911264A 1990-05-02 1991-05-02 Polymeric mixture, process for its preparation and a pharmaceutical containing said mixture CS126491A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51799990A 1990-05-02 1990-05-02
US07/681,032 US5300288A (en) 1991-04-05 1991-04-05 Composition and method for controlling cholesterol

Publications (1)

Publication Number Publication Date
CS126491A3 true CS126491A3 (en) 1992-02-19

Family

ID=27059303

Family Applications (1)

Application Number Title Priority Date Filing Date
CS911264A CS126491A3 (en) 1990-05-02 1991-05-02 Polymeric mixture, process for its preparation and a pharmaceutical containing said mixture

Country Status (15)

Country Link
EP (1) EP0459632A1 (no)
JP (1) JPH04298508A (no)
KR (1) KR910019631A (no)
CN (1) CN1056056A (no)
AU (1) AU7592991A (no)
CA (1) CA2040996A1 (no)
CS (1) CS126491A3 (no)
FI (1) FI912109A (no)
HU (1) HUT59944A (no)
IE (1) IE911405A1 (no)
IL (1) IL97973A0 (no)
NO (1) NO911700L (no)
NZ (1) NZ237993A (no)
PL (1) PL290121A1 (no)
PT (1) PT97549A (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE104154T1 (de) * 1990-07-26 1994-04-15 Searle & Co Arzneimittel freisetzendes polymeres system.
EP0548794B1 (de) * 1991-12-20 1999-06-09 Hoechst Aktiengesellschaft Polyaspartamidderivate als Adsorptionsmittel für Gallensäuren, mit Gallensäuren beladene Polyaspartamidderivate und Verfahren zu deren Herstellung sowie deren Anwendung als Arzneimittel
EP0563731B1 (de) * 1992-03-28 1995-11-15 Hoechst Aktiengesellschaft Arzneimittel aus Polyhydroxymethylenderivaten, Verfahren zu deren Herstellung und Verwendung
US5556619A (en) * 1992-08-20 1996-09-17 The Du Pont Merck Pharmaceutical Company Crosslinked polymeric ammonium salts
US5451397A (en) * 1992-12-21 1995-09-19 Rohm And Haas Company Bile acid sequestrant
US5487888A (en) * 1993-05-20 1996-01-30 Geltex, Inc. Iron-binding polymers for oral administration
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US5618530A (en) * 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5900475A (en) * 1994-06-10 1999-05-04 Geltex Pharmaceuticals, Inc. Hydrophobic sequestrant for cholesterol depletion
US5703188A (en) * 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
ZA95390B (en) * 1994-01-18 1996-07-18 Du Pont Crosslinked polymeric ammonium salts
US5414068A (en) * 1994-01-24 1995-05-09 Rohm And Haas Company Crosslinked anion exchange particles and method for producing the particles
IL110943A (en) * 1994-09-13 1997-02-18 Univ Ramot Compositions comprising an inhibitor of cholesterol synthesis for the treatment of skin disorders
US6203785B1 (en) 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
DE19715504C2 (de) 1997-04-14 2000-10-26 Max Planck Gesellschaft PMMA-Membranen mit Polyethylenglykol-gekoppelten Wirksubstanzen
US6423754B1 (en) 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
GB2329334A (en) * 1997-09-18 1999-03-24 Reckitt & Colmann Prod Ltd Cholesterol-lowering agents
US6726905B1 (en) 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
CO5251465A1 (es) 2000-01-26 2003-02-28 Pfizer Prod Inc Composiciones y procedimientos para tratar la osteoporosis y reducir el colesterol
FR2848452B1 (fr) * 2002-12-12 2007-04-06 Aventis Pharma Sa Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer
WO2024040380A1 (zh) * 2022-08-22 2024-02-29 中美华世通生物医药科技(武汉)股份有限公司 铵盐聚合物及其制备方法和作为胆汁酸螯合剂的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3308020A (en) * 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
GB1359932A (en) * 1972-03-21 1974-07-17 Lubrizol Corp N-3-aminoalkyl amides polymers thereof and method for their prepa ration
EP0013416B1 (de) * 1978-12-27 1985-09-18 Chemische Fabrik Stockhausen GmbH Verfahren zur Herstellung von alpha-beta-ungesättigten N-substituierten Carbonsäureamiden, neue alpha-beta-ungesättigte N-substituierte Carbonsäureamide und ihre Verwendung zur Herstellung von Ionenaustauschern

Also Published As

Publication number Publication date
JPH04298508A (ja) 1992-10-22
PL290121A1 (no) 1992-01-27
IE911405A1 (en) 1991-11-06
NZ237993A (en) 1993-08-26
FI912109A0 (fi) 1991-04-30
EP0459632A1 (en) 1991-12-04
KR910019631A (ko) 1991-12-19
CA2040996A1 (en) 1991-11-03
PT97549A (pt) 1992-01-31
NO911700D0 (no) 1991-04-30
IL97973A0 (en) 1992-06-21
AU7592991A (en) 1991-11-07
NO911700L (no) 1991-11-04
FI912109A (fi) 1991-11-03
HU911391D0 (en) 1991-10-28
HUT59944A (en) 1992-07-28
CN1056056A (zh) 1991-11-13

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