CR20230451A - Agonistas del receptor de glucocorticoides - Google Patents
Agonistas del receptor de glucocorticoidesInfo
- Publication number
- CR20230451A CR20230451A CR20230451A CR20230451A CR20230451A CR 20230451 A CR20230451 A CR 20230451A CR 20230451 A CR20230451 A CR 20230451A CR 20230451 A CR20230451 A CR 20230451A CR 20230451 A CR20230451 A CR 20230451A
- Authority
- CR
- Costa Rica
- Prior art keywords
- receptor agonists
- glucocorticoid receptor
- pharmaceutically acceptable
- acceptable salt
- ortho
- Prior art date
Links
- 229940124750 glucocorticoid receptor agonist Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
Abstract
La presente invención proporciona un compuesto de la Fórmula I: en donde R es H o; R<sup>1</sup> es H, halógeno, alquilo C1-C3, cicloalquilo C3-C6, alcoxi C1-C3, alquenilo C2-C3, OCF<sub>3</sub>,; R<sup>2</sup> es H, halógeno, alquilo C1-C3, alcoxi C1-C3 o alquenilo C2-C4; R<sup>3</sup> es NH<sub>2</sub>, o CH<sub>2</sub>NH<sub>2</sub>; y X es O, OCH<sub>2</sub>, OCH<sub>2</sub>CH<sub>2</sub>, OCH(CH<sub>3</sub>), CH<sub>2</sub>O, SCH<sub>2</sub>, CH<sub>2</sub>S, CH<sub>2</sub>, NHCH<sub>2</sub>, CH<sub>2</sub>NH, N(CH<sub>3</sub>)CH<sub>2</sub>, CH<sub>2</sub>CH<sub>2</sub>, C=C, o un enlace, en donde X está conectado al anillo de fenilo A en la posición orto o meta, o una sal farmacéuticamente aceptable de este, en donde el compuesto de la Fórmula I, o una sal farmacéuticamente aceptable de este, es útil para tratar enfermedades autoinmunes e inflamatorias, tales como dermatitis atópica y artritis reumatoide.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163164613P | 2021-03-23 | 2021-03-23 | |
| US202163260451P | 2021-08-20 | 2021-08-20 | |
| PCT/US2022/021299 WO2022204108A1 (en) | 2021-03-23 | 2022-03-22 | Glucocorticoid receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20230451A true CR20230451A (es) | 2023-10-11 |
Family
ID=81325459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20230451A CR20230451A (es) | 2021-03-23 | 2022-03-22 | Agonistas del receptor de glucocorticoides |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11787834B2 (es) |
| EP (1) | EP4314005A1 (es) |
| JP (1) | JP2024510774A (es) |
| KR (1) | KR20230145487A (es) |
| AU (1) | AU2022242757A1 (es) |
| BR (1) | BR112023016448A2 (es) |
| CA (1) | CA3209170A1 (es) |
| CO (1) | CO2023012249A2 (es) |
| CR (1) | CR20230451A (es) |
| DO (1) | DOP2023000201A (es) |
| EC (1) | ECSP23071886A (es) |
| IL (1) | IL305277A (es) |
| TW (1) | TW202304462A (es) |
| WO (1) | WO2022204108A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240082414A1 (en) * | 2022-05-13 | 2024-03-14 | Eli Lilly And Company | Human tumor necrosis factor alpha antibody glucocorticoid conjugates |
| WO2023235738A1 (en) * | 2022-06-02 | 2023-12-07 | Eli Lilly And Company | Human interleukin-4 receptor alpha antibody glucocorticoid conjugates |
| WO2024064779A1 (en) * | 2022-09-22 | 2024-03-28 | Eli Lilly And Company | Glucocorticoid receptor agonists |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004071389A2 (en) * | 2003-02-15 | 2004-08-26 | Glaxo Group Limited | Non-steroidal infalmmation inhibitors |
| BRPI0611567A2 (pt) | 2005-06-14 | 2016-11-16 | Gilead Sciences Inc | composto e/ou sais farmaceuticamente aceitáveis dos mesmos, processo para síntese dos compostos, e formulação aerossol, e, uso de pelo menos uma pró-droga mútua de fenilfosfato |
| NZ585434A (en) | 2007-11-30 | 2012-06-29 | Pfizer Ltd | Novel glucocorticoid receptor agonists |
| US8524697B2 (en) | 2007-12-21 | 2013-09-03 | Merck Sharp & Dohme Corp. | C20-C21 substituted glucocorticoid receptor agonists |
| BRPI0907789A2 (pt) | 2008-02-27 | 2019-01-22 | Astrazeneca Ab | derivaldos 16-alfa e 17-alfa de glicocorticosteroides e seus usos |
| US11510993B2 (en) | 2015-10-06 | 2022-11-29 | Merck Sharp & Dohme Llc | Antibody drug conjugate for anti-inflammatory applications |
| WO2017132103A2 (en) | 2016-01-29 | 2017-08-03 | Merck Sharp & Dohme Corp. | Phosphonate linkers and their use to facilitate cellular retention of compounds |
| MY194619A (en) | 2016-06-02 | 2022-12-07 | Abbvie Inc | Glucocorticoid receptor agonist and immunoconjugates thereof |
| SG10202104259RA (en) | 2016-11-08 | 2021-06-29 | Regeneron Pharma | Steroids and protein-conjugates thereof |
| RU2020117156A (ru) * | 2017-12-01 | 2022-01-04 | Эббви Инк. | Конъюгаты анти-cd40 антитела и лекарственного средства |
| TWI803542B (zh) * | 2017-12-01 | 2023-06-01 | 美商艾伯維有限公司 | 糖皮質激素受體激動劑及其免疫結合物 |
| CA3176161A1 (en) | 2020-04-22 | 2021-10-28 | Jay ROTHSTEIN | Anti-human vista antibodies and use thereof |
-
2022
- 2022-03-15 TW TW111109320A patent/TW202304462A/zh unknown
- 2022-03-22 BR BR112023016448A patent/BR112023016448A2/pt unknown
- 2022-03-22 KR KR1020237032195A patent/KR20230145487A/ko active Search and Examination
- 2022-03-22 CR CR20230451A patent/CR20230451A/es unknown
- 2022-03-22 US US17/700,943 patent/US11787834B2/en active Active
- 2022-03-22 JP JP2023558316A patent/JP2024510774A/ja active Pending
- 2022-03-22 CA CA3209170A patent/CA3209170A1/en active Pending
- 2022-03-22 AU AU2022242757A patent/AU2022242757A1/en active Pending
- 2022-03-22 EP EP22715884.7A patent/EP4314005A1/en active Pending
- 2022-03-22 IL IL305277A patent/IL305277A/en unknown
- 2022-03-22 WO PCT/US2022/021299 patent/WO2022204108A1/en active Application Filing
-
2023
- 2023-09-08 US US18/463,293 patent/US20240018182A1/en active Pending
- 2023-09-18 CO CONC2023/0012249A patent/CO2023012249A2/es unknown
- 2023-09-20 DO DO2023000201A patent/DOP2023000201A/es unknown
- 2023-09-22 EC ECSENADI202371886A patent/ECSP23071886A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DOP2023000201A (es) | 2023-10-15 |
| ECSP23071886A (es) | 2023-10-31 |
| CO2023012249A2 (es) | 2023-09-29 |
| BR112023016448A2 (pt) | 2023-10-24 |
| US20220324904A1 (en) | 2022-10-13 |
| TW202304462A (zh) | 2023-02-01 |
| KR20230145487A (ko) | 2023-10-17 |
| WO2022204108A1 (en) | 2022-09-29 |
| AU2022242757A1 (en) | 2023-08-24 |
| IL305277A (en) | 2023-10-01 |
| US20240018182A1 (en) | 2024-01-18 |
| US11787834B2 (en) | 2023-10-17 |
| CA3209170A1 (en) | 2022-09-29 |
| JP2024510774A (ja) | 2024-03-11 |
| EP4314005A1 (en) | 2024-02-07 |
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