CR20190026A - Composición vaginal que comprende una combinación de estrógeno y vitamina d - Google Patents

Composición vaginal que comprende una combinación de estrógeno y vitamina d

Info

Publication number
CR20190026A
CR20190026A CR20190026A CR20190026A CR20190026A CR 20190026 A CR20190026 A CR 20190026A CR 20190026 A CR20190026 A CR 20190026A CR 20190026 A CR20190026 A CR 20190026A CR 20190026 A CR20190026 A CR 20190026A
Authority
CR
Costa Rica
Prior art keywords
vitamin
combination
estrogen
vaginal composition
vaginal
Prior art date
Application number
CR20190026A
Other languages
English (en)
Inventor
Enrico; Colli
David F ; Archer
Original Assignee
Chemo Res S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Res S L filed Critical Chemo Res S L
Publication of CR20190026A publication Critical patent/CR20190026A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/065—Diphenyl-substituted acyclic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención se refiere a no a una composición vaginal que comprende una combinación de estrón-Y vitamina-D y un anánlogo de vitamina-D en una dosis diaria de (i) estrón-que corresponde a 1 µg a 100 µg de deestro-equivalente de estradiol-y (ii) vitamina-Do-anánlogo que corresponde a 7,5 µg a 100 µg de Vitamina-D-equivalencia.
CR20190026A 2016-07-22 2017-07-20 Composición vaginal que comprende una combinación de estrógeno y vitamina d CR20190026A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16305941.3A EP3272333A1 (en) 2016-07-22 2016-07-22 Vaginal composition comprising a combination of estrogen and vitamin d
PCT/EP2017/068391 WO2018015503A1 (en) 2016-07-22 2017-07-20 Vaginal composition comprising a combination of estrogen and vitamin d

Publications (1)

Publication Number Publication Date
CR20190026A true CR20190026A (es) 2019-04-09

Family

ID=56561320

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20190026A CR20190026A (es) 2016-07-22 2017-07-20 Composición vaginal que comprende una combinación de estrógeno y vitamina d

Country Status (10)

Country Link
US (2) US20190224213A1 (es)
EP (2) EP3272333A1 (es)
BR (1) BR112019001207A2 (es)
CL (1) CL2019000174A1 (es)
CO (1) CO2019000604A2 (es)
CR (1) CR20190026A (es)
MX (1) MX2019000806A (es)
NI (1) NI201900004A (es)
PH (1) PH12019500137A1 (es)
WO (1) WO2018015503A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112088010A (zh) 2018-05-04 2020-12-15 宝洁公司 用于治疗阴道干燥的组合物和方法
EP3787659A1 (en) * 2018-05-04 2021-03-10 The Procter & Gamble Company Compositions and methods for treating vaginal atrophy
EP4066824A1 (en) * 2021-03-31 2022-10-05 Dompe' Farmaceutici S.P.A. Combination therapy for covid-19 vaccination

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3062715A (en) 1953-11-18 1962-11-06 George S Pfaus Vaginal tablet
IE61236B1 (en) 1986-07-15 1994-10-19 American Home Prod Combination dosage form for pre-menopausal women
GB8723846D0 (en) 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system
US5514698A (en) 1994-03-21 1996-05-07 Ortho Pharmaceutical Corporation Antifungal vaginal cream composition
JP3705620B2 (ja) 1994-12-28 2005-10-12 帝国臓器製薬株式会社 経粘膜投与用製剤
EP0889724A1 (en) 1996-02-27 1999-01-13 Rpms Technology Limited Cox-2 selective inhibitors for managing labour and uterine contractions
DE19608423A1 (de) 1996-03-05 1997-09-11 Merck Patent Gmbh Implantate mit phasenweiser Arzneistoffabgabe
TW358031B (en) 1997-04-11 1999-05-11 Akze Nobel N V Drug delivery system for 2 or more active substances
US20050276836A1 (en) 1997-06-11 2005-12-15 Michelle Wilson Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents
US6197327B1 (en) 1997-06-11 2001-03-06 Umd, Inc. Device and method for treatment of dysmenorrhea
US6905701B2 (en) 1997-06-11 2005-06-14 Umd, Inc. Formulations for transmucosal vaginal delivery of bisphosphonates
US20040043071A1 (en) 2002-06-21 2004-03-04 Pauletti Giovanni M. Intravaginal mucosal or transmucosal delivery of antimigraine and antinausea drugs
FR2766710B1 (fr) 1997-08-04 1999-10-29 Inst Pharma De Rech Applic Et Composition pharmaceutique, comprime forme a partir de celle-ci et son utilisation comme antiseptique vaginal a action prolongee
DE19916419B4 (de) 1999-04-08 2005-06-16 Schering Ag Kombinationspräparat aus Vitamin-D-Metaboliten oder Vitamin-D-Analoga und einem Östrogenpartialagonisten zur Behandlung von Osteoporose
US6855703B1 (en) * 2000-03-10 2005-02-15 Endeavor Pharmaceuticals Pharmaceutical compositions of conjugated estrogens and methods of analyzing mixtures containing estrogenic compounds
WO2002047692A1 (en) * 2000-12-15 2002-06-20 Novo Nordisk A/S Use of an oestrogen in the manufacture of a composition containing oestrogen for the treatment of atrophic vaginitis
US7004171B2 (en) 2002-02-25 2006-02-28 Hi-Gienic Intra Vaginal Technologies Ltd. System for transvaginal drug delivery
WO2004103232A1 (en) 2003-05-15 2004-12-02 Apothecus Pharmaceutical Corp. Dissolvable vaginal deodorizing films and methods of vaginal deodorizing utilizing pliable dissolvable film
JP2007502823A (ja) 2003-08-15 2007-02-15 キューエルティー・ユーエスエイ・インコーポレーテッド 接着性および生体侵食性の経粘膜薬物送達システム
US20050070501A1 (en) 2003-09-29 2005-03-31 New York Blood Center, Inc. Water dispersible film
US20060040904A1 (en) 2004-08-17 2006-02-23 Ahmed Salah U Vaginal cream compositions, kits thereof and methods of using thereof
CN101175503B (zh) 2005-04-27 2012-12-12 深圳福诺生物技术有限公司 一种调节并保持阴道菌群和阴道酸度正常的组合物与方法
US20090247493A1 (en) 2006-01-27 2009-10-01 Duramed Pharmaceuticals, Inc. Regimens for Treatment of Conditions Related to Estrogen Deficiency
EP2146698A2 (en) 2007-05-24 2010-01-27 New York Blood Center, Inc. Rapidly dispersible vaginal tablet that provides a bioadhesive gel
US20080312198A1 (en) 2007-06-14 2008-12-18 Rodriguez Gustavo C Pharmaceutical products containing hormones and a 25-hydroxy vitamin d compound
IN2012DN00711A (es) 2009-07-21 2015-06-19 Population Council Inc
US8980304B2 (en) 2010-08-20 2015-03-17 Teva Women's Health, Inc. Barrel-shaped vaginal ring
CN102641548B (zh) 2011-02-18 2016-08-03 帕洛阿尔托研究中心公司 包括化学品渗透增强剂的透粘膜药物输送装置和方法
JP5887424B2 (ja) 2011-12-29 2016-03-16 ウニベルシダッド デ チリ Ｄｈｅａまたは硫酸ｄｈｅａを有し、かつ有効成分の放出調節薬を任意に有し、女性における卵巣予備能を増やし、かつ閉経期に関連する症状を緩和する膣リング
EP2799043B1 (en) 2011-12-29 2019-11-27 Laboratorios Andrómaco S.A. Vaginal ring including meloxicam and an agent for modulating the release of the active principle, which can be used as a continuous-use contraceptive in women
ITMI20120867A1 (it) 2012-05-18 2013-11-19 Labomar S R L Composizione per il trattamento di lesioni.
FR3018193B1 (fr) 2014-03-10 2017-09-08 Probionov Comprime vaginal muco-adhesif a liberation prolongee
SG11201607600TA (en) * 2014-03-13 2016-10-28 Singapore Ze&Z Internat Pte Ltd Vaginal composition and use thereof
WO2016054002A1 (en) 2014-09-29 2016-04-07 Yale University Progesterone impregnated vaginal ring/pessary

Also Published As

Publication number Publication date
CO2019000604A2 (es) 2019-05-21
CL2019000174A1 (es) 2019-06-28
US20210069210A1 (en) 2021-03-11
US20190224213A1 (en) 2019-07-25
EP3487478A1 (en) 2019-05-29
PH12019500137A1 (en) 2019-07-29
WO2018015503A1 (en) 2018-01-25
MX2019000806A (es) 2019-06-20
NI201900004A (es) 2019-04-29
BR112019001207A2 (pt) 2019-04-30
EP3272333A1 (en) 2018-01-24
US11590145B2 (en) 2023-02-28

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