CR11481A - Antagonista de la ruta de hedgehog y aplicaciones terapeuticas de los mismos - Google Patents
Antagonista de la ruta de hedgehog y aplicaciones terapeuticas de los mismosInfo
- Publication number
- CR11481A CR11481A CR11481A CR11481A CR11481A CR 11481 A CR11481 A CR 11481A CR 11481 A CR11481 A CR 11481A CR 11481 A CR11481 A CR 11481A CR 11481 A CR11481 A CR 11481A
- Authority
- CR
- Costa Rica
- Prior art keywords
- therapeutic applications
- antagonist
- same
- hedgehog
- route
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos heterociclicos que modulan la via de senalizacion de hedgehog, su composicion farmaceutica y sus aplicaciones terapeuticas
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07024218 | 2007-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR11481A true CR11481A (es) | 2010-10-15 |
Family
ID=39432963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR11481A CR11481A (es) | 2007-12-13 | 2010-06-08 | Antagonista de la ruta de hedgehog y aplicaciones terapeuticas de los mismos |
Country Status (16)
Country | Link |
---|---|
US (1) | US8592463B2 (es) |
EP (1) | EP2227456A2 (es) |
JP (1) | JP5620821B2 (es) |
CN (1) | CN101896472A (es) |
AR (1) | AR069652A1 (es) |
AU (1) | AU2008335880B2 (es) |
BR (1) | BRPI0820856A2 (es) |
CA (1) | CA2709203A1 (es) |
CO (1) | CO6210735A2 (es) |
CR (1) | CR11481A (es) |
EA (1) | EA017918B1 (es) |
IL (1) | IL206298A0 (es) |
NZ (1) | NZ586121A (es) |
TW (1) | TW200930370A (es) |
WO (1) | WO2009074300A2 (es) |
ZA (1) | ZA201004185B (es) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
JP5639895B2 (ja) | 2007-12-27 | 2014-12-10 | インフィニティ ファーマスーティカルズ、インク. | 立体選択的還元方法 |
PE20091180A1 (es) * | 2007-12-27 | 2009-08-26 | Infinity Pharmaceuticals Inc | Tratamientos terapeuticos contra el cancer |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
JP5807971B2 (ja) * | 2009-04-27 | 2015-11-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cxcr3受容体アンタゴニスト |
BR112012000303A2 (pt) * | 2009-06-11 | 2016-11-16 | Siena Biotech Spa | antagonistas da via hedgehog e aplicações terapêuticas dos mesmos |
AR077014A1 (es) * | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
WO2011017551A1 (en) | 2009-08-05 | 2011-02-10 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
WO2011084985A1 (en) | 2010-01-07 | 2011-07-14 | Boehringer Ingelheim International Gmbh | Cxcr3 receptor antagonists |
WO2011088404A1 (en) * | 2010-01-15 | 2011-07-21 | Infinity Pharmaceuticals , Inc | Treatment of fibrotic conditions using hedgehog inhibitors |
JP5951600B2 (ja) | 2010-05-21 | 2016-07-13 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | キナーゼ調節のための、化合物、組成物および方法 |
US9376447B2 (en) | 2010-09-14 | 2016-06-28 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
CA2817577A1 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
EP2468726B1 (en) | 2010-12-06 | 2013-08-28 | Siena Biotech S.p.A. | Compound for the treatment of tumours and tumour metastases |
US8809349B2 (en) | 2011-01-10 | 2014-08-19 | Infinity Pharmaceuticals, Inc. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
AU2012284088B2 (en) | 2011-07-19 | 2015-10-08 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
AR088218A1 (es) | 2011-07-19 | 2014-05-21 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos utiles como inhibidores de pi3k |
US9891149B2 (en) | 2011-08-08 | 2018-02-13 | Thermo Fisher Scientific Oy | Method and apparatus for automated analysis |
FI20115785A0 (fi) * | 2011-08-08 | 2011-08-08 | Thermo Fisher Scientific Oy | Menetelmä ja laite automaattiseen analyysiin |
EP2751093A1 (en) | 2011-08-29 | 2014-07-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2013049332A1 (en) | 2011-09-29 | 2013-04-04 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
CA2851082A1 (en) * | 2011-10-06 | 2013-04-11 | Merck Sharp & Dohme Corp. | 1,3-substituted azetidine pde10 inhibitors |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
PT2914296T (pt) | 2012-11-01 | 2018-10-30 | Infinity Pharmaceuticals Inc | Tratamento de cancros utilizando moduladores de isoformas de pi3-quinase |
NZ629037A (en) | 2013-03-15 | 2017-04-28 | Infinity Pharmaceuticals Inc | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
US9192609B2 (en) | 2013-04-17 | 2015-11-24 | Hedgepath Pharmaceuticals, Inc. | Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors |
CN103288803B (zh) * | 2013-05-17 | 2017-10-31 | 郎恒元 | 苯并咪唑酰胺类化合物及其制备方法和应用 |
DK3003309T3 (da) | 2013-05-30 | 2020-12-14 | Infinity Pharmaceuticals Inc | Behandling af cancer med PI3-kinase-isoform modulatorer |
PL3003038T3 (pl) | 2013-06-07 | 2020-02-28 | The Scripps Research Institute | Pochodne 2H-1,2,3-triazoli jako inhibitory zwłóknienia |
PE20160685A1 (es) | 2013-10-04 | 2016-07-23 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos |
US20160244452A1 (en) | 2013-10-21 | 2016-08-25 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
FR3017867A1 (fr) * | 2014-02-21 | 2015-08-28 | Inventiva | Nouveaux composes de type phenylazetidine carboxylate ou carboxamide |
SG10201808053XA (en) | 2014-03-19 | 2018-10-30 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
US20150320754A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
CN107404878B (zh) | 2014-12-10 | 2021-03-30 | 斯克利普斯研究所 | 纤维化的小分子抑制剂 |
MX2017015681A (es) | 2015-06-04 | 2018-09-11 | Pellepharm Inc | Formulaciones topicas para suministrar compuestos inhibidores de hedgehog y uso de los mismos. |
US20170231968A1 (en) | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Method for relief of and treatment of pruritus |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN109640999A (zh) | 2016-06-24 | 2019-04-16 | 无限药品股份有限公司 | 组合疗法 |
CN109232533A (zh) * | 2017-09-28 | 2019-01-18 | 北京越之康泰生物医药科技有限公司 | 氮杂环类衍生物、其制备方法及其医药用途 |
WO2019062657A1 (zh) * | 2017-09-30 | 2019-04-04 | 北京越之康泰生物医药科技有限公司 | 氮杂环类衍生物、其制备方法及其医药用途 |
CN110016054B (zh) * | 2019-03-15 | 2021-10-22 | 四川大学 | 含磷氮苯并杂环结构的离子单体、用其阻燃的共聚酯型离聚物及它们的制备方法和应用 |
CN114790177B (zh) * | 2021-01-26 | 2024-03-26 | 首都医科大学附属北京天坛医院 | 新型Hedgehog信号通路抑制剂 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7781596B1 (en) | 1998-11-03 | 2010-08-24 | Abbott Laboratories | Substituted 2-phenylbenzimidazoles, the production thereof and their use |
CA2464000C (en) * | 2001-10-19 | 2011-04-19 | Ortho-Mcneil Pharmaceutical, Inc. | 2-phenyl benzimidazoles and imidazo-[4,5]-pyridines as cdsi/chk2-inhibitors and adjuvants to chemotherapy or radiation therapy in the treatment of cancer |
ES2373875T3 (es) * | 2002-03-05 | 2012-02-09 | Transtech Pharma, Inc. | Derivados de azol mono y bicíclicos que inhiben la interacción de ligandos con rage. |
BR112012000303A2 (pt) * | 2009-06-11 | 2016-11-16 | Siena Biotech Spa | antagonistas da via hedgehog e aplicações terapêuticas dos mesmos |
-
2008
- 2008-12-10 BR BRPI0820856-5A patent/BRPI0820856A2/pt not_active IP Right Cessation
- 2008-12-10 JP JP2010537305A patent/JP5620821B2/ja not_active Expired - Fee Related
- 2008-12-10 WO PCT/EP2008/010470 patent/WO2009074300A2/en active Application Filing
- 2008-12-10 EP EP08860550A patent/EP2227456A2/en not_active Withdrawn
- 2008-12-10 EA EA201000784A patent/EA017918B1/ru not_active IP Right Cessation
- 2008-12-10 CA CA2709203A patent/CA2709203A1/en not_active Abandoned
- 2008-12-10 CN CN2008801207308A patent/CN101896472A/zh active Pending
- 2008-12-10 AU AU2008335880A patent/AU2008335880B2/en not_active Ceased
- 2008-12-10 NZ NZ586121A patent/NZ586121A/en not_active IP Right Cessation
- 2008-12-10 US US12/747,562 patent/US8592463B2/en not_active Expired - Fee Related
- 2008-12-11 AR ARP080105382A patent/AR069652A1/es not_active Application Discontinuation
- 2008-12-11 TW TW097148178A patent/TW200930370A/zh unknown
-
2010
- 2010-05-27 CO CO10063835A patent/CO6210735A2/es active IP Right Grant
- 2010-06-08 CR CR11481A patent/CR11481A/es not_active Application Discontinuation
- 2010-06-10 IL IL206298A patent/IL206298A0/en unknown
- 2010-06-11 ZA ZA2010/04185A patent/ZA201004185B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2008335880A1 (en) | 2009-06-18 |
US20100286114A1 (en) | 2010-11-11 |
JP5620821B2 (ja) | 2014-11-05 |
EA017918B1 (ru) | 2013-04-30 |
JP2011506366A (ja) | 2011-03-03 |
WO2009074300A2 (en) | 2009-06-18 |
NZ586121A (en) | 2012-03-30 |
AU2008335880B2 (en) | 2014-03-13 |
ZA201004185B (en) | 2011-10-26 |
CA2709203A1 (en) | 2009-06-18 |
TW200930370A (en) | 2009-07-16 |
BRPI0820856A2 (pt) | 2019-05-14 |
CN101896472A (zh) | 2010-11-24 |
CO6210735A2 (es) | 2010-10-20 |
IL206298A0 (en) | 2010-12-30 |
EA201000784A1 (ru) | 2010-12-30 |
US8592463B2 (en) | 2013-11-26 |
WO2009074300A3 (en) | 2009-10-01 |
AR069652A1 (es) | 2010-02-10 |
WO2009074300A8 (en) | 2009-11-19 |
EP2227456A2 (en) | 2010-09-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CR11481A (es) | Antagonista de la ruta de hedgehog y aplicaciones terapeuticas de los mismos | |
CL2015003139A1 (es) | Variantes de polipéptidos receptores de activina y usos de los mismos. | |
UY35485A (es) | Compuestos heterocíclicos y usos de los mismos | |
CL2008003188A1 (es) | Compuestos derivados de piridina y pirazina; composicion farmaceutica que los comprende;y su uso en el tratamiento o prevencion de tumores sensibles a la inhibicion de enzimas del receptor ax1 y/o c-met. | |
CL2011000691A1 (es) | Compuestos derivados de nicotinamida sustituida; composicion farmaceutica que los comprende; uso para el tratamiento y/o prevencion de cancer, infecciones, enfermedades inflamatorias y autoinmunitarias. | |
AR062875A1 (es) | Compuestos de n- metilaminometil isoindol y composiciones que los comprenden y metodos para utilizarlos | |
GT201000376A (es) | Compuestos organicos | |
UY31314A1 (es) | Amidas heterociclicas y sus métodos de uso-976 | |
UY32036A (es) | Derivados de ciclohexil-amida, composiciones farmacéuticas que los contienen, su preparación y aplicaciones | |
UY30498A1 (es) | Nueva clase de compuestos de benzimidazolilo, sus sales, composiciones farmacéuticas conteniéndolos y aplicaciones | |
DK1983964T3 (da) | Anordning til indgivelse af lægemiddel | |
HN2008000179A (es) | Compuestos triciclicos,composiciones y procedimientos | |
SV2009003307A (es) | Quinazolinas para la inhibicion de pdk1 | |
CO6450665A2 (es) | Anticuerpos anti-fgfr3 y métodos que los utilizan | |
ECSP099785A (es) | Anticuerpos anti-notch1 nrr y sus métodos de uso | |
GT200900027A (es) | Compuestos organicos | |
UY30846A1 (es) | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos | |
CL2007001674A1 (es) | Compuestos derivados de heterociclos, inhibidores de aspartil proteasa; composicion farmaceutica que los comprende;y su uso para tratar enfermedades cardiovasculares,cognitivas y neurodegenerativas. | |
AR059978A1 (es) | Composiciones farmaceuticas | |
CL2007002166A1 (es) | Compuestos derivados de heterociclos de nitrogeno, antagonistas de los inhibidores de las proteinas de la apoptosis; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento del cancer. | |
ECSP11011347A (es) | Nicotinamida sustituida como moduladores KCNQ2/3 | |
SV2010003556A (es) | Moleculas y metodos para modular el componente de complemento | |
ATE544759T1 (de) | 5-pyridinon-substituierte indazole und pharmazeutische zusammensetzungen davon | |
HN2008001393A (es) | Derivados de 1,2,4,5- tetrahidro -3h- benzazepinas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen | |
HN2009000566A (es) | Nuevos derivados de diosmetina, su procedimiento de prearacion y las composiciones farmaceuticas que lo contienen. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal (granting procedure) |