CR10924A - Metodo para estabilidad mejorada de derivados de esteroides - Google Patents

Metodo para estabilidad mejorada de derivados de esteroides

Info

Publication number
CR10924A
CR10924A CR10924A CR10924A CR10924A CR 10924 A CR10924 A CR 10924A CR 10924 A CR10924 A CR 10924A CR 10924 A CR10924 A CR 10924A CR 10924 A CR10924 A CR 10924A
Authority
CR
Costa Rica
Prior art keywords
improved stability
steroid derivatives
compositions
norprogesterone
steroids
Prior art date
Application number
CR10924A
Other languages
English (en)
Spanish (es)
Inventor
Podolski Joseph
Original Assignee
Repros Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Repros Therapeutics Inc filed Critical Repros Therapeutics Inc
Publication of CR10924A publication Critical patent/CR10924A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CR10924A 2007-01-17 2009-07-14 Metodo para estabilidad mejorada de derivados de esteroides CR10924A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88536307P 2007-01-17 2007-01-17

Publications (1)

Publication Number Publication Date
CR10924A true CR10924A (es) 2009-10-30

Family

ID=39387140

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10924A CR10924A (es) 2007-01-17 2009-07-14 Metodo para estabilidad mejorada de derivados de esteroides

Country Status (16)

Country Link
EP (1) EP2125858A2 (fr)
JP (1) JP2010516686A (fr)
KR (1) KR20090105944A (fr)
CN (1) CN101616926A (fr)
AR (1) AR064947A1 (fr)
AU (1) AU2008206599A1 (fr)
BR (1) BRPI0806572A2 (fr)
CA (1) CA2674440A1 (fr)
CL (1) CL2008000138A1 (fr)
CR (1) CR10924A (fr)
EA (1) EA200970692A1 (fr)
EC (1) ECSP099537A (fr)
IL (1) IL199684A0 (fr)
MX (1) MX2009007313A (fr)
TW (1) TW200835503A (fr)
WO (1) WO2008088935A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI477276B (zh) * 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
US8512745B2 (en) 2008-12-08 2013-08-20 Laboratoire Hra Pharma Ulipristal acetate tablets
HUP0900171A2 (hu) * 2009-03-20 2010-12-28 Richter Gedeon Nyrt 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására
HUP0900487A2 (hu) * 2009-08-05 2011-03-28 Richter Gedeon Nyrt 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos polimorf módosulata és eljárás elõállítására

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US8044223B2 (en) * 2003-04-04 2011-10-25 Bridge Organics Co. Crystalline 19-norsteroids

Also Published As

Publication number Publication date
BRPI0806572A2 (pt) 2014-05-06
IL199684A0 (en) 2010-04-15
CA2674440A1 (fr) 2008-07-24
WO2008088935A3 (fr) 2009-03-05
EA200970692A1 (ru) 2010-02-26
EP2125858A2 (fr) 2009-12-02
CL2008000138A1 (es) 2008-05-16
AU2008206599A1 (en) 2008-07-24
JP2010516686A (ja) 2010-05-20
MX2009007313A (es) 2009-07-15
KR20090105944A (ko) 2009-10-07
WO2008088935A2 (fr) 2008-07-24
TW200835503A (en) 2008-09-01
ECSP099537A (es) 2009-08-28
AR064947A1 (es) 2009-05-06
CN101616926A (zh) 2009-12-30

Similar Documents

Publication Publication Date Title
BR112014012444A2 (pt) formulações e terapias de reposição hormonal natural combinada
BR112012009306A2 (pt) método para regeneração de mielina em um paciente
ECSP099536A (es) Métodos y formulaciones para biodisponibilidad mejorada de antiprogestinas
HK1201274A1 (en) 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof 33- 19-
BR112014031910A2 (pt) formulações e terapias naturais de combinação para reposição hormonal
UY32239A (es) Nuevos derivados de (3-oxo)piridazin-4-ilurea
BRPI1008227A8 (pt) composição de glicocorticoide inalável para uso na terapia de um paciente que sofre de asma severa e sem controle.
EP2533799A4 (fr) Procédé pour l'utilisation de progestogène comme sensibilisateur aux glucocorticoïdes
BR112012030810A2 (pt) "c-28 amidas de derivados de ácido c-3 betulínico modificados como inibidores de maturação de hiv"
MX2013012971A (es) Composiciones de yodopovidona estables con antiinflamatorios esteroides y no esteroides.
CR11427A (es) 2-fluoro-2 - desoxitetrahidrouridinas como inhibidores de citidina desaminasa
WO2010088409A3 (fr) Procédés de neuroprotection utilisant des stéroïdes neuroprotecteurs et une vitamine d
WO2013016668A3 (fr) Promédicaments méthylphénidates, procédés de fabrication et d'utilisation de ceux-ci
CL2010001348A1 (es) Compuestos derivados de 1-oxo-2,3-dihidro-1h-isoindolin-5-il)-isoxazol-3-carboxamida, potenciadores de los mglur2; composicion farmaceutica; y su uso para aliviar los sintomas o disminuir la aparicion de los sintomas de ezquizofrenia o ansiedad.
UY32659A (es) Pirazinilpirazoles
WO2008065316A3 (fr) Compositions sous forme d'onguent comprenant un derive de vitamine d
BRPI0822165A2 (pt) Método para manter concentrações plasmáticas sustentadas de progesterona em seres humanos, composição farmacêutica, uso de uma composição farmecêutica e suspensão aquosa injetável.
CR10924A (es) Metodo para estabilidad mejorada de derivados de esteroides
WO2011059969A3 (fr) Métabolites de stéroïdes de mammifères
WO2011095535A3 (fr) Dérivés de pyrrolidine
CL2011002675A1 (es) Uso de compuestos derivados de nitrato o sulfato de 9-purin-9-il-3,4-dihidroxitetrahidrofuran-2-il-metilo para reducir la presion intraocular ; composicion farmaceutica oftalmica que comprende los compuestos; y formulacion oftalmica de uso topico que los comprende.
CU20110185A7 (es) Nuevos derivados de compuestos de [3,2-c]pirazol esteroidal con actividad glucocorticoide
BR112013007514A2 (pt) anticorpo isolado, uso da composição e método
BR112013021784A2 (pt) composição de reagente, e, método para a recuperação de um metal de uma solução aquosa
CO6602170A2 (es) Composiciones y metodos para la administracion no toxica de antiprogestinas

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)