AR064947A1 - Metodos para mejorar la estabilidad de derivados esteroides - Google Patents
Metodos para mejorar la estabilidad de derivados esteroidesInfo
- Publication number
- AR064947A1 AR064947A1 ARP080100217A ARP080100217A AR064947A1 AR 064947 A1 AR064947 A1 AR 064947A1 AR P080100217 A ARP080100217 A AR P080100217A AR P080100217 A ARP080100217 A AR P080100217A AR 064947 A1 AR064947 A1 AR 064947A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- alkoxy
- salt
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Composiciones con estabilidad mejorada que comprenden una sal aceptable para uso farmacéutico de un compuesto relacionado con los esteroides. Reivindicacion 1: Una composicion caracterizada porque comprende una sal aceptable para uso farmacéutico de un compuesto con la formula general (1) donde: R1 es un grupo funcional básico que se selecciona entre el grupo que consiste en -N(CH3)2, -NHCH3, -NC4H8, -NC5H10, y -NC4H8O; R2 es un miembro que se selecciona entre el grupo que consiste en hidrogeno, halogeno, alquilo, acilo, hidroxi, alcoxi, aciloxi, carbonato de alquilo, cipioniloxi, S-alquilo, -SCN, S-acilo, y -OC(O)R6, donde R6 es un miembro que se selecciona entre el grupo que consiste en alquilo, alcoxi éster y alcoxi; R3 es un miembro que se selecciona entre el grupo que consiste en alquil-alcoxi, alcoxi y aciloxi; R4 es un miembro que se selecciona entre el grupo que consiste en hidrogeno y alquilo; X es un miembro que se selecciona entre el grupo que consiste en =O y =N- OR5, donde R5 es un miembro que se selecciona entre el grupo que consiste en hidrogeno y alquilo; donde dicha sal aceptable para uso farmacéutico tiene mayor estabilidad en comparacion con una cantidad equivalente de la base libre de dicho compuesto; y con la condicion de que cuando R1 es -N(CH3)2, R2 es metoxi, R3 es acetoxi, R4 es metilo y X es =O, la sal no es una sal de HCI o HBr. Reivindicacion 2: La composicion de la reivindicacion 1, caracterizada porque dicho compuesto es 17alfa-acetoxi-11beta-[4-(N,N-dimetilamino)fenil]-19-norpregna-4,9(10)-dieno-3,20-diona. Reivindicacion 8: Un método para producir un efecto antiprogestágeno en un paciente, caracterizado porque dicho método comprende administrar a dicho paciente una cantidad efectiva de la composicion de la reivindicacion 1 o la reivindicacion 6.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88536307P | 2007-01-17 | 2007-01-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR064947A1 true AR064947A1 (es) | 2009-05-06 |
Family
ID=39387140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080100217A AR064947A1 (es) | 2007-01-17 | 2008-01-17 | Metodos para mejorar la estabilidad de derivados esteroides |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP2125858A2 (es) |
JP (1) | JP2010516686A (es) |
KR (1) | KR20090105944A (es) |
CN (1) | CN101616926A (es) |
AR (1) | AR064947A1 (es) |
AU (1) | AU2008206599A1 (es) |
BR (1) | BRPI0806572A2 (es) |
CA (1) | CA2674440A1 (es) |
CL (1) | CL2008000138A1 (es) |
CR (1) | CR10924A (es) |
EA (1) | EA200970692A1 (es) |
EC (1) | ECSP099537A (es) |
IL (1) | IL199684A0 (es) |
MX (1) | MX2009007313A (es) |
TW (1) | TW200835503A (es) |
WO (1) | WO2008088935A2 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI477276B (zh) * | 2008-04-28 | 2015-03-21 | Repros Therapeutics Inc | 抗黃體素給藥方案 |
US8512745B2 (en) | 2008-12-08 | 2013-08-20 | Laboratoire Hra Pharma | Ulipristal acetate tablets |
HUP0900171A2 (hu) * | 2009-03-20 | 2010-12-28 | Richter Gedeon Nyrt | 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására |
HUP0900487A2 (hu) * | 2009-08-05 | 2011-03-28 | Richter Gedeon Nyrt | 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos polimorf módosulata és eljárás elõállítására |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
US6020328A (en) * | 1998-03-06 | 2000-02-01 | Research Triangle Institute | 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
US8044223B2 (en) * | 2003-04-04 | 2011-10-25 | Bridge Organics Co. | Crystalline 19-norsteroids |
-
2008
- 2008-01-03 JP JP2009546454A patent/JP2010516686A/ja not_active Withdrawn
- 2008-01-03 CA CA002674440A patent/CA2674440A1/en not_active Abandoned
- 2008-01-03 CN CN200880002367A patent/CN101616926A/zh active Pending
- 2008-01-03 WO PCT/US2008/050128 patent/WO2008088935A2/en active Application Filing
- 2008-01-03 EP EP08713475A patent/EP2125858A2/en not_active Withdrawn
- 2008-01-03 KR KR1020097015532A patent/KR20090105944A/ko not_active Application Discontinuation
- 2008-01-03 AU AU2008206599A patent/AU2008206599A1/en not_active Abandoned
- 2008-01-03 MX MX2009007313A patent/MX2009007313A/es not_active Application Discontinuation
- 2008-01-03 EA EA200970692A patent/EA200970692A1/ru unknown
- 2008-01-03 BR BRPI0806572-1A patent/BRPI0806572A2/pt not_active IP Right Cessation
- 2008-01-15 TW TW097101566A patent/TW200835503A/zh unknown
- 2008-01-17 AR ARP080100217A patent/AR064947A1/es unknown
- 2008-01-17 CL CL200800138A patent/CL2008000138A1/es unknown
-
2009
- 2009-07-02 IL IL199684A patent/IL199684A0/en unknown
- 2009-07-14 CR CR10924A patent/CR10924A/es not_active Application Discontinuation
- 2009-07-23 EC EC2009009537A patent/ECSP099537A/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL199684A0 (en) | 2010-04-15 |
BRPI0806572A2 (pt) | 2014-05-06 |
TW200835503A (en) | 2008-09-01 |
WO2008088935A3 (en) | 2009-03-05 |
CL2008000138A1 (es) | 2008-05-16 |
CR10924A (es) | 2009-10-30 |
ECSP099537A (es) | 2009-08-28 |
AU2008206599A1 (en) | 2008-07-24 |
MX2009007313A (es) | 2009-07-15 |
CA2674440A1 (en) | 2008-07-24 |
EA200970692A1 (ru) | 2010-02-26 |
KR20090105944A (ko) | 2009-10-07 |
JP2010516686A (ja) | 2010-05-20 |
WO2008088935A2 (en) | 2008-07-24 |
CN101616926A (zh) | 2009-12-30 |
EP2125858A2 (en) | 2009-12-02 |
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Legal Events
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