CO7240426A2 - Célula hospedera bacteriana recombinante para expresión de proteína - Google Patents

Célula hospedera bacteriana recombinante para expresión de proteína

Info

Publication number
CO7240426A2
CO7240426A2 CO14272157A CO14272157A CO7240426A2 CO 7240426 A2 CO7240426 A2 CO 7240426A2 CO 14272157 A CO14272157 A CO 14272157A CO 14272157 A CO14272157 A CO 14272157A CO 7240426 A2 CO7240426 A2 CO 7240426A2
Authority
CO
Colombia
Prior art keywords
host cell
protein expression
bacterial host
recombinant bacterial
recombinant
Prior art date
Application number
CO14272157A
Other languages
English (en)
Inventor
Philip Jonathan Bassett
David Paul Humphreys
Pareshkumar Manjibhai Patel
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Publication of CO7240426A2 publication Critical patent/CO7240426A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

VER PESTAÑA ANEXOS
CO14272157A 2012-05-14 2014-12-11 Célula hospedera bacteriana recombinante para expresión de proteína CO7240426A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201208367A GB201208367D0 (en) 2012-05-14 2012-05-14 Biological product

Publications (1)

Publication Number Publication Date
CO7240426A2 true CO7240426A2 (es) 2015-04-17

Family

ID=46458730

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14272157A CO7240426A2 (es) 2012-05-14 2014-12-11 Célula hospedera bacteriana recombinante para expresión de proteína

Country Status (29)

Country Link
US (2) US9951365B2 (es)
EP (1) EP2850100B1 (es)
JP (2) JP6420759B2 (es)
KR (1) KR102036399B1 (es)
CN (2) CN104487454A (es)
AU (1) AU2013261915B2 (es)
BR (1) BR112014027357A2 (es)
CA (1) CA2872328C (es)
CL (1) CL2014003112A1 (es)
CO (1) CO7240426A2 (es)
CY (1) CY1121192T1 (es)
DK (1) DK2850100T3 (es)
EA (1) EA201492100A1 (es)
ES (1) ES2704425T3 (es)
GB (1) GB201208367D0 (es)
HR (1) HRP20190025T1 (es)
HU (1) HUE040624T2 (es)
IL (1) IL235041B (es)
LT (1) LT2850100T (es)
ME (1) ME03309B (es)
MX (1) MX353066B (es)
MY (1) MY166223A (es)
PL (1) PL2850100T3 (es)
PT (1) PT2850100T (es)
RS (1) RS58219B1 (es)
SG (1) SG11201406474RA (es)
SI (1) SI2850100T1 (es)
TR (1) TR201900073T4 (es)
WO (1) WO2013171156A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE040306T2 (hu) 2009-09-24 2019-03-28 Ucb Biopharma Sprl Baktériumtörzs rekombináns fehérje expresszálására, amely tartalmaz proteázhiányos, de chaperonaktivitását megtartott DEGP-t és génkiütött TSP és PTR gént
GB201000587D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000590D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000591D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201012599D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
SG10201807560XA (en) 2011-07-13 2018-10-30 Ucb Pharma Sa Bacterial host strain expressing recombinant dsbc
GB201208367D0 (en) * 2012-05-14 2012-06-27 Ucb Pharma Sa Biological product
GB201708655D0 (en) * 2017-05-31 2017-07-12 Ucb Biopharma Sprl Cell culture methods
EP3492582A1 (en) 2017-12-01 2019-06-05 UCB Biopharma SPRL Cell culture methods
WO2019193418A1 (en) 2018-04-05 2019-10-10 Bio-Rad Abd Serotec Gmbh Display systems for proteins of interest
WO2019213331A1 (en) * 2018-05-01 2019-11-07 Ambrx, Inc. A method for optimizing antibody expression
CA3117051A1 (en) * 2018-11-05 2020-05-14 Genentech, Inc. Methods of producing two chain proteins in prokaryotic host cells
JP2022525775A (ja) * 2019-03-18 2022-05-19 バイオ-ラッド エービーディー セロテック ゲーエムベーハー SpyTag含有ペリプラズム融合タンパク質のプロテアーゼTSP及びOMPT分解からの保護
AU2023281650A1 (en) 2022-05-30 2024-10-17 Hanall Biopharma Co., Ltd. Anti-fcrn antibody or antigen binding fragment thereof with improved stability

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508192A (en) 1990-11-09 1996-04-16 Board Of Regents, The University Of Texas System Bacterial host strains for producing proteolytically sensitive polypeptides
US5264365A (en) 1990-11-09 1993-11-23 Board Of Regents, The University Of Texas System Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides
GB9215540D0 (en) 1992-07-22 1992-09-02 Celltech Ltd Protein expression system
US5304472A (en) 1992-11-20 1994-04-19 Genentech, Inc. Method of controlling polypeptide production in bacterial cells
US6027888A (en) 1996-04-05 2000-02-22 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide-bond containing eukaryotic proteins in bacterial cells
US6083715A (en) 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
JP3711326B2 (ja) 1998-10-28 2005-11-02 ジェネンテック・インコーポレーテッド 細菌性細胞からの異種ポリペプチドの回収方法
WO2001001147A1 (en) 1999-06-29 2001-01-04 Siga Technologies, Inc. Assay for degp protease inhibitors
GB0006398D0 (en) 2000-03-16 2000-05-03 Novartis Ag Organic compounds
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
AU8867501A (en) 2000-09-01 2002-03-13 Biogen Inc Co-crystal structure of monoclonal antibody 5c8 and cd154, and use thereof in drug design
AU2001287040A1 (en) 2000-09-01 2002-03-13 Biogen, Inc. Methods of designing and producing novel compounds having improved binding affinity for cd154 or other trimeric proteins
US7041479B2 (en) 2000-09-06 2006-05-09 The Board Of Trustess Of The Leland Stanford Junior University Enhanced in vitro synthesis of active proteins containing disulfide bonds
ATE405650T1 (de) * 2000-12-14 2008-09-15 Genentech Inc Produktion von ganzen antikörpern in prokaryontischen zellen
MXPA03005271A (es) 2000-12-14 2003-09-25 Genentech Inc Cepas huesped bacteriales.
TWI334439B (en) 2001-08-01 2010-12-11 Centocor Inc Anti-tnf antibodies, compositions, methods and uses
US20030077739A1 (en) 2001-08-27 2003-04-24 Genentech, Inc. System for antibody expression and assembly
GB0124317D0 (en) 2001-10-10 2001-11-28 Celltech R&D Ltd Biological products
EP2022799A2 (en) 2001-11-16 2009-02-11 Biogen Idec Inc. Polycistronic expression of antibodies
GB0129105D0 (en) 2001-12-05 2002-01-23 Celltech R&D Ltd Expression control using variable intergenic sequences
CN1678634A (zh) 2002-06-28 2005-10-05 多曼蒂斯有限公司 免疫球蛋白单个变体抗原结合区及其特异性构建体
GB0224082D0 (en) 2002-10-16 2002-11-27 Celltech R&D Ltd Biological products
WO2004042017A2 (en) 2002-10-31 2004-05-21 Genentech, Inc. Methods and compositions for increasing antibody production
AU2003285578B2 (en) 2002-12-03 2010-07-15 Ucb Pharma S.A. Assay for identifying antibody producing cells
GB0303337D0 (en) 2003-02-13 2003-03-19 Celltech R&D Ltd Biological products
JP4667383B2 (ja) 2003-06-13 2011-04-13 バイオジェン・アイデック・エムエイ・インコーポレイテッド アグリコシル抗cd154(cd40リガンド)抗体およびその使用
SI1639011T1 (sl) 2003-06-30 2009-04-30 Domantis Ltd Pegilirana protitelesa z enojno domeno (dAb)
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
EP1653801A4 (en) 2003-07-26 2007-05-30 Biogen Idec Inc MODIFIED ANTIBODIES HAVING IMPROVED ANTIGEN BINDING AFFINITY
WO2006078273A2 (en) * 2004-04-26 2006-07-27 The United States Of America As Represented By Teh Secretary Of Health And Human Services, Nih Methods and compositions for producing recombinant proteins
CZ200755A3 (cs) 2004-07-26 2007-04-11 Biogen Idec Ma Inc. Peptidy protilátek anti-CD154
MX2007002856A (es) 2004-09-02 2007-09-25 Genentech Inc Metodos para el uso de ligandos receptores de muerte y anticuerpos c20.
US7563443B2 (en) 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
GB0425534D0 (en) 2004-11-19 2004-12-22 Celltech R&D Ltd Process for obtaining antibodies
GB0520169D0 (en) 2005-10-04 2005-11-09 Celltech R&D Ltd Biological products
MY166021A (en) 2007-03-22 2018-05-21 Biogen Ma Inc Binding proteins,including antibodies,antibody derivatives and antibody fragments,that specifically bind cd154 and uses thereof
CN104004088B (zh) 2007-09-26 2017-11-07 Ucb医药有限公司 双特异性抗体融合物
PL2334705T3 (pl) 2008-09-26 2017-06-30 Ucb Biopharma Sprl Produkty biologiczne
US7662587B1 (en) 2009-03-05 2010-02-16 E. I. Du Pont De Nemours And Company Gene knockout mutations that increase peptide production
HUE040306T2 (hu) 2009-09-24 2019-03-28 Ucb Biopharma Sprl Baktériumtörzs rekombináns fehérje expresszálására, amely tartalmaz proteázhiányos, de chaperonaktivitását megtartott DEGP-t és génkiütött TSP és PTR gént
US8470552B2 (en) 2009-10-12 2013-06-25 Keck Graduate Institute Strategy to reduce lactic acid production and control PH in animal cell culture
EP2496601B1 (en) 2009-11-05 2017-06-07 F. Hoffmann-La Roche AG Methods and composition for secretion of heterologous polypeptides
GB201000590D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000587D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000591D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000588D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201001791D0 (en) 2010-02-03 2010-03-24 Ucb Pharma Sa Process for obtaining antibodies
GB201012599D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
EP2546267A1 (en) * 2011-07-13 2013-01-16 UCB Pharma S.A. Bacterial host strain expressing recombinant DsbC
SG10201807560XA (en) 2011-07-13 2018-10-30 Ucb Pharma Sa Bacterial host strain expressing recombinant dsbc
GB201208367D0 (en) * 2012-05-14 2012-06-27 Ucb Pharma Sa Biological product

Also Published As

Publication number Publication date
LT2850100T (lt) 2019-01-25
CL2014003112A1 (es) 2015-06-19
DK2850100T3 (en) 2019-02-04
WO2013171156A1 (en) 2013-11-21
EP2850100A1 (en) 2015-03-25
SI2850100T1 (sl) 2019-02-28
JP6420759B2 (ja) 2018-11-07
EA201492100A1 (ru) 2015-02-27
BR112014027357A2 (pt) 2017-08-08
EP2850100B1 (en) 2018-10-10
HRP20190025T1 (hr) 2019-02-22
US20150111249A1 (en) 2015-04-23
US20180258457A1 (en) 2018-09-13
US9951365B2 (en) 2018-04-24
GB201208367D0 (en) 2012-06-27
JP2015516166A (ja) 2015-06-11
HUE040624T2 (hu) 2019-03-28
PL2850100T3 (pl) 2019-04-30
KR20150014936A (ko) 2015-02-09
CN104487454A (zh) 2015-04-01
SG11201406474RA (en) 2014-11-27
JP2018198597A (ja) 2018-12-20
CN110591991A (zh) 2019-12-20
AU2013261915A1 (en) 2014-12-18
CA2872328C (en) 2020-10-13
IL235041A0 (en) 2014-12-31
CY1121192T1 (el) 2020-05-29
KR102036399B1 (ko) 2019-10-24
MX2014012623A (es) 2015-01-15
AU2013261915B2 (en) 2017-12-14
ES2704425T3 (es) 2019-03-18
RS58219B1 (sr) 2019-03-29
ME03309B (me) 2019-10-20
MY166223A (en) 2018-06-22
TR201900073T4 (tr) 2019-01-21
CA2872328A1 (en) 2013-11-21
MX353066B (es) 2017-12-19
US11261470B2 (en) 2022-03-01
IL235041B (en) 2019-10-31
PT2850100T (pt) 2019-01-21

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