SG11201406474RA - Recombinant bacterial host cell for protein expression - Google Patents
Recombinant bacterial host cell for protein expressionInfo
- Publication number
- SG11201406474RA SG11201406474RA SG11201406474RA SG11201406474RA SG11201406474RA SG 11201406474R A SG11201406474R A SG 11201406474RA SG 11201406474R A SG11201406474R A SG 11201406474RA SG 11201406474R A SG11201406474R A SG 11201406474RA SG 11201406474R A SG11201406474R A SG 11201406474RA
- Authority
- SG
- Singapore
- Prior art keywords
- host cell
- protein expression
- bacterial host
- recombinant bacterial
- recombinant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201208367A GB201208367D0 (en) | 2012-05-14 | 2012-05-14 | Biological product |
| PCT/EP2013/059803 WO2013171156A1 (en) | 2012-05-14 | 2013-05-13 | Recombinant bacterial host cell for protein expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201406474RA true SG11201406474RA (en) | 2014-11-27 |
Family
ID=46458730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201406474RA SG11201406474RA (en) | 2012-05-14 | 2013-05-13 | Recombinant bacterial host cell for protein expression |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US9951365B2 (en) |
| EP (1) | EP2850100B1 (en) |
| JP (2) | JP6420759B2 (en) |
| KR (1) | KR102036399B1 (en) |
| CN (2) | CN110591991A (en) |
| AU (1) | AU2013261915B2 (en) |
| BR (1) | BR112014027357A2 (en) |
| CA (1) | CA2872328C (en) |
| CL (1) | CL2014003112A1 (en) |
| CO (1) | CO7240426A2 (en) |
| CY (1) | CY1121192T1 (en) |
| DK (1) | DK2850100T3 (en) |
| EA (1) | EA201492100A1 (en) |
| ES (1) | ES2704425T3 (en) |
| GB (1) | GB201208367D0 (en) |
| HR (1) | HRP20190025T1 (en) |
| HU (1) | HUE040624T2 (en) |
| IL (1) | IL235041B (en) |
| LT (1) | LT2850100T (en) |
| ME (1) | ME03309B (en) |
| MX (1) | MX353066B (en) |
| MY (1) | MY166223A (en) |
| PL (1) | PL2850100T3 (en) |
| PT (1) | PT2850100T (en) |
| RS (1) | RS58219B1 (en) |
| SG (1) | SG11201406474RA (en) |
| SI (1) | SI2850100T1 (en) |
| TR (1) | TR201900073T4 (en) |
| WO (1) | WO2013171156A1 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE040306T2 (en) | 2009-09-24 | 2019-03-28 | Ucb Biopharma Sprl | Bacterial strain for recombinant protein expression, having protease deficient degp retaining chaperone activity, and knocked out tsp and ptr genes |
| GB201000587D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201000590D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
| GB201000591D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201012599D0 (en) | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Process for purifying proteins |
| SI2731973T1 (en) | 2011-07-13 | 2018-04-30 | Ucb Biopharma Aprl | Bacterial host strain expressing recombinant dsbc |
| GB201208367D0 (en) * | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
| GB201708655D0 (en) * | 2017-05-31 | 2017-07-12 | Ucb Biopharma Sprl | Cell culture methods |
| US11453883B2 (en) | 2018-04-05 | 2022-09-27 | Bio-Rad Abd Serotec Gmbh | Display systems for proteins of interest |
| CA3098910A1 (en) * | 2018-05-01 | 2019-11-07 | Ambrx, Inc. | A method for optimizing antibody expression |
| TW202031899A (en) * | 2018-11-05 | 2020-09-01 | 美商建南德克公司 | Methods of producing two chain proteins in prokaryotic host cells |
| JP2022525775A (en) * | 2019-03-18 | 2022-05-19 | バイオ－ラッド エービーディー セロテック ゲーエムベーハー | Protection of SpyTag-containing periplasmic fusion proteins from protease TSP and OMPT degradation |
| US11926669B2 (en) | 2022-05-30 | 2024-03-12 | Hanall Biopharma Co., Ltd. | Anti-FcRn antibody or antigen binding fragment thereof with improved stability |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5508192A (en) | 1990-11-09 | 1996-04-16 | Board Of Regents, The University Of Texas System | Bacterial host strains for producing proteolytically sensitive polypeptides |
| US5264365A (en) | 1990-11-09 | 1993-11-23 | Board Of Regents, The University Of Texas System | Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides |
| GB9215540D0 (en) | 1992-07-22 | 1992-09-02 | Celltech Ltd | Protein expression system |
| US5304472A (en) | 1992-11-20 | 1994-04-19 | Genentech, Inc. | Method of controlling polypeptide production in bacterial cells |
| WO1997038123A1 (en) | 1996-04-05 | 1997-10-16 | Board Of Regents, The University Of Texas System | Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells |
| US6083715A (en) | 1997-06-09 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells |
| ATE415469T1 (en) | 1998-10-28 | 2008-12-15 | Genentech Inc | METHOD FOR OBTAINING HETEROLOGUE POLYPEPTIDES FROM BACTERIAL CELLS |
| ATE343790T1 (en) | 1999-06-29 | 2006-11-15 | Siga Technologies Inc | TEST FOR DEGP-PROTEASE INHIBITORS |
| GB0006398D0 (en) | 2000-03-16 | 2000-05-03 | Novartis Ag | Organic compounds |
| GB0013810D0 (en) | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
| AU8867501A (en) | 2000-09-01 | 2002-03-13 | Biogen Inc | Co-crystal structure of monoclonal antibody 5c8 and cd154, and use thereof in drug design |
| AU2001287040A1 (en) | 2000-09-01 | 2002-03-13 | Biogen, Inc. | Methods of designing and producing novel compounds having improved binding affinity for cd154 or other trimeric proteins |
| US7041479B2 (en) | 2000-09-06 | 2006-05-09 | The Board Of Trustess Of The Leland Stanford Junior University | Enhanced in vitro synthesis of active proteins containing disulfide bonds |
| AU3957602A (en) | 2000-12-14 | 2002-06-24 | Genentech Inc | Bacterial host strains |
| AU2002245142B2 (en) * | 2000-12-14 | 2007-07-05 | Genentech, Inc. | Prokaryotically produced antibodies and uses thereof |
| TWI334439B (en) | 2001-08-01 | 2010-12-11 | Centocor Inc | Anti-tnf antibodies, compositions, methods and uses |
| MXPA04001566A (en) | 2001-08-27 | 2004-05-17 | Genentech Inc | A system for antibody expression and assembly. |
| GB0124317D0 (en) | 2001-10-10 | 2001-11-28 | Celltech R&D Ltd | Biological products |
| EA007905B1 (en) | 2001-11-16 | 2007-02-27 | Байоджен Айдек Инк. | Polycistronic expression of antibodies |
| GB0129105D0 (en) | 2001-12-05 | 2002-01-23 | Celltech R&D Ltd | Expression control using variable intergenic sequences |
| SI1517921T1 (en) | 2002-06-28 | 2006-10-31 | Domantis Ltd | Dual specific ligands with increased serum half-life |
| GB0224082D0 (en) | 2002-10-16 | 2002-11-27 | Celltech R&D Ltd | Biological products |
| MXPA05004677A (en) | 2002-10-31 | 2005-11-17 | Genentech Inc | Methods and compositions for increasing antibody production. |
| ES2374068T3 (en) | 2002-12-03 | 2012-02-13 | Ucb Pharma, S.A. | TEST TO IDENTIFY ANTIBODY PRODUCTION CELLS. |
| GB0303337D0 (en) | 2003-02-13 | 2003-03-19 | Celltech R&D Ltd | Biological products |
| JP4667383B2 (en) | 2003-06-13 | 2011-04-13 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Aglycosyl anti-CD154 (CD40 ligand) antibody and use thereof |
| AU2004220325B2 (en) | 2003-06-30 | 2011-05-12 | Domantis Limited | Polypeptides |
| GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| GB0315457D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| WO2005011376A2 (en) | 2003-07-26 | 2005-02-10 | Biogen Idec Ma Inc | Altered antibodies having improved antigen-binding affinity |
| WO2006078273A2 (en) * | 2004-04-26 | 2006-07-27 | The United States Of America As Represented By Teh Secretary Of Health And Human Services, Nih | Methods and compositions for producing recombinant proteins |
| RS20070027A (en) | 2004-07-26 | 2008-11-28 | Biogen Idec Ma Inc., | Anti-cd154 antibodies |
| MX2007002856A (en) | 2004-09-02 | 2007-09-25 | Genentech Inc | Heteromultimeric molecules. |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| GB0425534D0 (en) | 2004-11-19 | 2004-12-22 | Celltech R&D Ltd | Process for obtaining antibodies |
| GB0520169D0 (en) | 2005-10-04 | 2005-11-09 | Celltech R&D Ltd | Biological products |
| SI2125894T1 (en) | 2007-03-22 | 2019-05-31 | Biogen Ma Inc. | Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof |
| EP2535351A3 (en) | 2007-09-26 | 2013-04-03 | UCB Pharma S.A. | Dual specificity antibody fusions |
| DK2334705T3 (en) | 2008-09-26 | 2017-03-27 | Ucb Biopharma Sprl | BIOLOGICAL PRODUCTS |
| US7662587B1 (en) | 2009-03-05 | 2010-02-16 | E. I. Du Pont De Nemours And Company | Gene knockout mutations that increase peptide production |
| HUE040306T2 (en) | 2009-09-24 | 2019-03-28 | Ucb Biopharma Sprl | Bacterial strain for recombinant protein expression, having protease deficient degp retaining chaperone activity, and knocked out tsp and ptr genes |
| US8470552B2 (en) | 2009-10-12 | 2013-06-25 | Keck Graduate Institute | Strategy to reduce lactic acid production and control PH in animal cell culture |
| ES2636971T3 (en) | 2009-11-05 | 2017-10-10 | F. Hoffmann-La Roche Ag | Procedures and composition for secretion of heterogeneous polypeptides |
| GB201000587D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201000590D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
| GB201000591D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201000588D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
| GB201001791D0 (en) | 2010-02-03 | 2010-03-24 | Ucb Pharma Sa | Process for obtaining antibodies |
| GB201012599D0 (en) | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Process for purifying proteins |
| SI2731973T1 (en) * | 2011-07-13 | 2018-04-30 | Ucb Biopharma Aprl | Bacterial host strain expressing recombinant dsbc |
| EP2546267A1 (en) * | 2011-07-13 | 2013-01-16 | UCB Pharma S.A. | Bacterial host strain expressing recombinant DsbC |
| GB201208367D0 (en) * | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
-
2012
- 2012-05-14 GB GB201208367A patent/GB201208367D0/en not_active Ceased
-
2013
- 2013-05-13 PT PT13723086T patent/PT2850100T/en unknown
- 2013-05-13 CN CN201910693072.1A patent/CN110591991A/en active Pending
- 2013-05-13 HU HUE13723086A patent/HUE040624T2/en unknown
- 2013-05-13 US US14/400,068 patent/US9951365B2/en active Active
- 2013-05-13 AU AU2013261915A patent/AU2013261915B2/en not_active Ceased
- 2013-05-13 CN CN201380025191.0A patent/CN104487454A/en active Pending
- 2013-05-13 RS RS20190013A patent/RS58219B1/en unknown
- 2013-05-13 PL PL13723086T patent/PL2850100T3/en unknown
- 2013-05-13 ES ES13723086T patent/ES2704425T3/en active Active
- 2013-05-13 MX MX2014012623A patent/MX353066B/en active IP Right Grant
- 2013-05-13 SI SI201331318T patent/SI2850100T1/en unknown
- 2013-05-13 DK DK13723086.8T patent/DK2850100T3/en active
- 2013-05-13 SG SG11201406474RA patent/SG11201406474RA/en unknown
- 2013-05-13 CA CA2872328A patent/CA2872328C/en active Active
- 2013-05-13 KR KR1020147032673A patent/KR102036399B1/en active IP Right Grant
- 2013-05-13 EA EA201492100A patent/EA201492100A1/en unknown
- 2013-05-13 EP EP13723086.8A patent/EP2850100B1/en active Active
- 2013-05-13 TR TR2019/00073T patent/TR201900073T4/en unknown
- 2013-05-13 LT LTEP13723086.8T patent/LT2850100T/en unknown
- 2013-05-13 MY MYPI2014703261A patent/MY166223A/en unknown
- 2013-05-13 BR BR112014027357A patent/BR112014027357A2/en active Search and Examination
- 2013-05-13 ME MEP-2019-3A patent/ME03309B/en unknown
- 2013-05-13 WO PCT/EP2013/059803 patent/WO2013171156A1/en active Application Filing
- 2013-05-13 JP JP2015512012A patent/JP6420759B2/en active Active
-
2014
- 2014-10-07 IL IL23504114A patent/IL235041B/en active IP Right Grant
- 2014-11-14 CL CL2014003112A patent/CL2014003112A1/en unknown
- 2014-12-11 CO CO14272157A patent/CO7240426A2/en unknown
-
2018
- 2018-04-23 US US15/959,498 patent/US11261470B2/en active Active
- 2018-07-12 JP JP2018132619A patent/JP2018198597A/en not_active Abandoned
-
2019
- 2019-01-03 HR HRP20190025TT patent/HRP20190025T1/en unknown
- 2019-01-10 CY CY20191100022T patent/CY1121192T1/en unknown
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