CO7141467A2 - Mejorando la estabilidad postural y las funciones incidentales en pacientes - Google Patents
Mejorando la estabilidad postural y las funciones incidentales en pacientesInfo
- Publication number
- CO7141467A2 CO7141467A2 CO14189356A CO14189356A CO7141467A2 CO 7141467 A2 CO7141467 A2 CO 7141467A2 CO 14189356 A CO14189356 A CO 14189356A CO 14189356 A CO14189356 A CO 14189356A CO 7141467 A2 CO7141467 A2 CO 7141467A2
- Authority
- CO
- Colombia
- Prior art keywords
- patients
- parkinson
- disease
- systems
- patient
- Prior art date
Links
- 230000001144 postural effect Effects 0.000 title abstract 2
- 208000018737 Parkinson disease Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- QXWYKJLNLSIPIN-SFYZADRCSA-N droxidopa Chemical compound OC(=O)[C@H](N)[C@@H](O)C1=CC=C(O)C(O)=C1 QXWYKJLNLSIPIN-SFYZADRCSA-N 0.000 abstract 2
- 229960001104 droxidopa Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000001089 Multiple system atrophy Diseases 0.000 abstract 1
- 206010031127 Orthostatic hypotension Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
- 230000001272 neurogenic effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención proporciona métodos y sistemas para reducir las caídasen pacientes que se caen de manera recurrente. Específicamente, las composiciones,los sistemas, y los métodos pueden relacionarse con pacientes con enfermedad de Parkinson, particularmente dichos pacientes que están sufriendo de hipotensiónortostática neurogénica. Las composiciones, los sistemas, y los métodos comprendenel uso de droxidopa, opcionalmente en combinación con un agente activo adicional. Seha encontrado que la administración de la droxidopa reduce el número medio decaídas por paciente por semana, así como también proporciona mejorías en lapuntuación del paciente en la escala de evaluación de Hoehn y Yahr, lo cual esindicativo de las mejorías en la estabilidad postural, y proporciona mejorías en lapuntuación del paciente en la Escala Unificada para la Evaluación de la Enfermedad deParkinson, lo cual es indicativo de mejorías en la severidad de los síntomas motoresy/o no motores de la enfermedad de Parkinson.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261592755P | 2012-01-31 | 2012-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO7141467A2 true CO7141467A2 (es) | 2014-12-12 |
Family
ID=47714573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO14189356A CO7141467A2 (es) | 2012-01-31 | 2014-08-28 | Mejorando la estabilidad postural y las funciones incidentales en pacientes |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20130197090A1 (es) |
| EP (1) | EP2809315A1 (es) |
| JP (1) | JP2015505563A (es) |
| KR (1) | KR20140131335A (es) |
| CN (1) | CN104220059A (es) |
| AU (1) | AU2013215282A1 (es) |
| BR (1) | BR112014018851A2 (es) |
| CA (1) | CA2863585A1 (es) |
| CO (1) | CO7141467A2 (es) |
| HK (1) | HK1200331A1 (es) |
| IL (1) | IL233855A0 (es) |
| IN (1) | IN2014DN07196A (es) |
| SG (1) | SG11201404496PA (es) |
| WO (1) | WO2013116325A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5880913B2 (ja) * | 2011-05-17 | 2016-03-09 | 三郎 佐古田 | パーキンソン病の体幹症状（姿勢反射異常）の治療剤 |
| CN104434868A (zh) * | 2013-09-18 | 2015-03-25 | 重庆圣华曦药业股份有限公司 | 一种稳定且利于在消化道溶出的屈昔多巴口服剂型 |
| CN115813923A (zh) | 2016-08-30 | 2023-03-21 | 施万生物制药研发Ip有限责任公司 | 用于治疗神经性起立性低血压的化合物 |
| US10902955B1 (en) * | 2020-05-01 | 2021-01-26 | Georgetown University | Detecting COVID-19 using surrogates |
| WO2021247963A1 (en) * | 2020-06-05 | 2021-12-09 | Senda Biosciences, Inc. | (s)-alpha-fluoromethyltyrosine as decarboxylase inhibitors for use in the treatment of hypotension |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3920728A (en) | 1973-08-22 | 1975-11-18 | Hoffmann La Roche | Separation and resolution of isomeric forms of 3-(3,4-dihydroxy-phenyl)-serine |
| JPS5629551A (en) | 1979-08-20 | 1981-03-24 | Sumitomo Chem Co Ltd | Preparation of optically active threo-3- 3,4- dihydroxyphenyl serine |
| US4480109A (en) | 1982-01-14 | 1984-10-30 | Sumitomo Chemical Company, Limited | Process for producing threo-3-(3,4-dihydroxyphenyl)serine |
| CA1223602A (en) | 1983-05-25 | 1987-06-30 | Naohito Ohashi | Process for producing 3-(3,4-dihydroxyphenyl) serine |
| JPS6098995A (ja) | 1983-11-04 | 1985-06-01 | Microbial Chem Res Found | 光学活性３−（３，４−ジヒドロキシフエニル）セリン，およびその誘導体の製造法 |
| US5288898A (en) | 1985-09-30 | 1994-02-22 | Zaidan Hojim Biseibutsu Kagaku Kenkyu Kai | N-methylphenylserine alkyl ester derivatives and uses thereof |
| DK175069B1 (da) | 1986-03-11 | 2004-05-24 | Hoffmann La Roche | Pyrocatecholderivater |
| YU213587A (en) | 1986-11-28 | 1989-06-30 | Orion Yhtymae Oy | Process for obtaining new pharmacologic active cateholic derivatives |
| DE19619510A1 (de) | 1995-05-18 | 1996-11-21 | Sumitomo Chemical Co | Verfahren zur Herstellung von Threo-3-(3,4-dihydroxyphenyl)serin |
| GB9510481D0 (en) | 1995-05-24 | 1995-07-19 | Orion Yhtymae Oy | New catechol derivatives |
| GB2344819A (en) | 1998-12-18 | 2000-06-21 | Portela & Ca Sa | 2-Phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones |
| CA2543322A1 (en) | 2003-10-21 | 2005-05-12 | Sention, Inc. | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents |
| WO2006123678A1 (ja) * | 2005-05-18 | 2006-11-23 | Dainippon Sumitomo Pharma Co., Ltd. | ドロキシドパを含有する安定な錠剤 |
| ATE548034T1 (de) | 2006-06-28 | 2012-03-15 | Chelsea Therapeutics Inc | Pharmazeutische zusammensetzungen mit droxidopa |
| ES2500053T3 (es) | 2007-03-09 | 2014-09-29 | Chelsea Therapeutics, Inc. | Composición farmacéutica que comprende droxidopa para el tratamiento de la fibromialgia |
-
2013
- 2013-01-30 CN CN201380017855.9A patent/CN104220059A/zh active Pending
- 2013-01-30 US US13/754,001 patent/US20130197090A1/en not_active Abandoned
- 2013-01-30 AU AU2013215282A patent/AU2013215282A1/en not_active Abandoned
- 2013-01-30 BR BR112014018851A patent/BR112014018851A2/pt not_active IP Right Cessation
- 2013-01-30 JP JP2014555668A patent/JP2015505563A/ja active Pending
- 2013-01-30 CA CA2863585A patent/CA2863585A1/en not_active Abandoned
- 2013-01-30 EP EP13704314.7A patent/EP2809315A1/en not_active Withdrawn
- 2013-01-30 IN IN7196DEN2014 patent/IN2014DN07196A/en unknown
- 2013-01-30 SG SG11201404496PA patent/SG11201404496PA/en unknown
- 2013-01-30 WO PCT/US2013/023828 patent/WO2013116325A1/en active Application Filing
- 2013-01-30 KR KR20147024284A patent/KR20140131335A/ko not_active Application Discontinuation
-
2014
- 2014-07-29 IL IL233855A patent/IL233855A0/en unknown
- 2014-08-28 CO CO14189356A patent/CO7141467A2/es not_active Application Discontinuation
-
2015
- 2015-01-23 HK HK15100783.4A patent/HK1200331A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013215282A1 (en) | 2014-08-28 |
| BR112014018851A2 (pt) | 2017-07-04 |
| IN2014DN07196A (es) | 2015-04-24 |
| US20130197090A1 (en) | 2013-08-01 |
| SG11201404496PA (en) | 2014-12-30 |
| CN104220059A (zh) | 2014-12-17 |
| CA2863585A1 (en) | 2013-08-08 |
| IL233855A0 (en) | 2014-09-30 |
| JP2015505563A (ja) | 2015-02-23 |
| WO2013116325A1 (en) | 2013-08-08 |
| EP2809315A1 (en) | 2014-12-10 |
| KR20140131335A (ko) | 2014-11-12 |
| HK1200331A1 (en) | 2015-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |