CO5560630A2 - Ensayo homogeneo de union de biopolimero por medio de mediciones multiples bajo condiciones variadas - Google Patents

Ensayo homogeneo de union de biopolimero por medio de mediciones multiples bajo condiciones variadas

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Publication number
CO5560630A2
CO5560630A2 CO04015669A CO04015669A CO5560630A2 CO 5560630 A2 CO5560630 A2 CO 5560630A2 CO 04015669 A CO04015669 A CO 04015669A CO 04015669 A CO04015669 A CO 04015669A CO 5560630 A2 CO5560630 A2 CO 5560630A2
Authority
CO
Colombia
Prior art keywords
stimulus
signal
test sample
probe
target
Prior art date
Application number
CO04015669A
Other languages
English (en)
Inventor
Glen H Erikson
Jasmine I Daksis
Pierre Picard
Original Assignee
Ingeneus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ingeneus Corp filed Critical Ingeneus Corp
Publication of CO5560630A2 publication Critical patent/CO5560630A2/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/30—Characterised by physical treatment
    • C12Q2523/307—Denaturation or renaturation by electric current/voltage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/107—Modifications characterised by incorporating a peptide nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/113—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being electroactive, e.g. redox labels

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

1.- Un método para ensayar hibridización especifica de secuencia, dicho método comprende: Suministrar un objetivo que comprende al menos una secuencia de biopolímero objetivo; suministrar una sonda que comprende al menos una secuencia de biopolímero sonda;agregar dicha sonda y dicho objetivo a un medio de unión para suministrar una muestra de ensayo; aplicar un primer estímulo a dicha muestra de ensayo para suministrar una primer muestra de ensayo estimulada;detectar una primer señal de dicha primer muestra de ensayo estimulada, en donde dicha primer señal esta correlacionada con afinidad de unión entre dicha sonda y dicho objetivo; aplicar un segundo estímulo a dicha primer muestra de ensayo estimulada para suministrar una segunda muestra de ensayo estimulada; detectar una segunda señal de dicha segunda muestra de ensayo estimulada, en donde dicha segunda señal esta correlacionada con dicha afinidad de unión entre dicha sonda y dicho objetivo; y compara dicha primer señal y dicha segunda señal para lograr dicho ensayo; en donde al menos una etiqueta se suministra en dicha muestra de ensayo, y dicho primer estimulo, dicho segundo estimulo, dicha primer señal y dicha segunda señal son radiación electromagnética, siempre y cuando, cuando dicho primer estimulo y dicho segundo estimulo son de radiación fotónica, un estimulo electrónico intermedio se aplica a dicha muestra de ensayo después de dicho primer estimulo y antes de dicho segundo estimulo, y en donde dicho primer estimulo y dicho segundo estimulo son radiación electrónica, dicha primer señal y dicha segunda señal son corriente eléctrica.
CO04015669A 2001-07-23 2004-02-23 Ensayo homogeneo de union de biopolimero por medio de mediciones multiples bajo condiciones variadas CO5560630A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/911,047 US7220541B2 (en) 2000-01-24 2001-07-23 Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions

Publications (1)

Publication Number Publication Date
CO5560630A2 true CO5560630A2 (es) 2005-09-30

Family

ID=25429687

Family Applications (1)

Application Number Title Priority Date Filing Date
CO04015669A CO5560630A2 (es) 2001-07-23 2004-02-23 Ensayo homogeneo de union de biopolimero por medio de mediciones multiples bajo condiciones variadas

Country Status (16)

Country Link
US (1) US7220541B2 (es)
EP (1) EP1461452A4 (es)
JP (1) JP2005527779A (es)
KR (1) KR100617427B1 (es)
CN (1) CN1671862A (es)
AU (1) AU2002317427B2 (es)
BR (1) BR0211350A (es)
CA (1) CA2454415A1 (es)
CO (1) CO5560630A2 (es)
IL (1) IL159928A0 (es)
MX (1) MXPA04000735A (es)
NZ (1) NZ531259A (es)
RU (1) RU2295572C2 (es)
TW (1) TWI274875B (es)
WO (1) WO2003010506A2 (es)
ZA (1) ZA200401363B (es)

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US20040142329A1 (en) * 2003-01-17 2004-07-22 Ingeneus Corporation Probe conjugation to increase multiplex binding motif preference
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Also Published As

Publication number Publication date
RU2295572C2 (ru) 2007-03-20
BR0211350A (pt) 2005-05-17
US7220541B2 (en) 2007-05-22
ZA200401363B (en) 2004-08-27
TWI274875B (en) 2007-03-01
IL159928A0 (en) 2004-06-20
EP1461452A2 (en) 2004-09-29
CN1671862A (zh) 2005-09-21
KR20040024588A (ko) 2004-03-20
NZ531259A (en) 2008-04-30
WO2003010506A3 (en) 2004-07-22
US20020137056A1 (en) 2002-09-26
AU2002317427B2 (en) 2006-08-17
CA2454415A1 (en) 2003-02-06
EP1461452A4 (en) 2006-06-21
WO2003010506A2 (en) 2003-02-06
MXPA04000735A (es) 2004-07-08
JP2005527779A (ja) 2005-09-15
RU2004105151A (ru) 2005-05-27
KR100617427B1 (ko) 2006-08-30

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