CO5290256A1 - Derivados pirazol triciclicos - Google Patents
Derivados pirazol triciclicosInfo
- Publication number
- CO5290256A1 CO5290256A1 CO01039467A CO01039467A CO5290256A1 CO 5290256 A1 CO5290256 A1 CO 5290256A1 CO 01039467 A CO01039467 A CO 01039467A CO 01039467 A CO01039467 A CO 01039467A CO 5290256 A1 CO5290256 A1 CO 5290256A1
- Authority
- CO
- Colombia
- Prior art keywords
- optionally substituted
- group
- formula
- phenyl
- heterocycloalkyl
- Prior art date
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P17/00—Drugs for dermatological disorders
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- A61P27/06—Antiglaucoma agents or miotics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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Abstract
Un compuesto caracterizado por que está representado por la fórmula:<EMI FILE="01039467_1" ID="1" IMF=JPEG >las mezclas racémicas, las mezclas racémico-diastereoméricas, tautómeros e isómeros ópticos de compuestos y las sales farmacéuticamente aceptables y las prodrogas de los mismos, en donde:m es un entero de 1 a 10;X representa a) un grupo opcionalmente sustituido de la fórmula -(CH2))n- en donde n es 1, 2 ó 3, b) carbonilo, c) oxígeno, d) un grupo de la fórmula -C=NOR10, en donde R10 es un grupo alquilo C1-4, e) un grupo de la fórmula NR11 én donde R11 es -H, un grupo alquilo C1-4 opcionalmente sustituido, o un fenilo opcionalmente sustituido, o f) un grupo de fórmula S(O)p en donde p es de valor 0, 1 ó 2;B representa un alquilo, un cicloalquilo, un arilo, un piridilo, un tienilo, un furilo o un pirrolilo; R1 es -H; un halo; hidroxilo; nitro; ciano; hidroxiamidino; aminometilo; formamidometilo; un alqueniloxilo opcionalmente sustituido; un alquenilo C2-4, opcionalmente sustituido; un alquinilo C2-4 opcionalmente sustituido; o un grupo representado por la fórmula -Y-W; con la condición que cuando R1 es - H, un alquilo C1-6 sin sustituir, un alcoxilo C1-6 sin sustituir, un halógeno, o trifluorometilo, el anillo A se sustituye con por lo menos un sustituyente que no es un halo, un alquilo C1-6 opcionalmente sustituido o un alcoxilo C1-6 opcionalmente sustituido;Y no está o es un alquilo C1-6, alcoxilo C1-6, -o-, -S- ó -C(O)-;W es -H, hidroxilo, fenilo opcionalmente sustituido, alcoxilo C1-6, o -NR2R3;con la condición que cuando el B es fenilo y R1 es -Y-W y W es -NR2R3, R2 y R3 son cada uno, independientemente, a) -H; b) un grupo alquilo C1-6 sustituido, con la condición que el sustituyente no es -NR6R7; - 2 -c) un cicloalquilo opcionalmente sustituido; d) un heterocicloalquilo opcionalmente sustituido; e) un cicloalquilalquilo opcionalmente sustituidos; f) un heterocicloalquilalquilo opcionalmente sustituido; g) un heteroarilo sustituido o un heteroaralquilo sustituido, con la condición que el heteroarilo o heteroaralquilo se sustituye con -NR9(CH2)1-6OR4, -NR9(CH2)1-6CO2R4, -NR9(CH2)1-6NR4R5, o un heterocicloalquilo opcionalmente sustituido; ocuando B es fenilo y R1, es -Y-W y W es -NR2R3, R2 y R3, junto con el átomo de nitrógeno a cual éstos están unidos, puede representar un heterocicloalquilo opcionalmente sustituido o un heteroarilo opcionalmente sustituido; cuando el B no es fenilo, R2 y R3, son cada uno, independientemente, -H, un grupo alquilo C1-6 opcionalmente sustituido, -NH(CH2)1-6NR4R5, un cicloalquilo opcionalmente sustituido, un heterocicloalquilo opcionalmente sustituido, un arilo opcionalmente sustituido, un heteroarilo opcionalmente sustituido, un cicloalquilalquilo opcionalmente sustituido, un heterocicloalquilalquilo opcionalmente sustituido, un aralquilo opcionalmente sustituido, o un heteroaralquilo opcionalmente sustituido; ocuando el B no es fenilo, R2 y R3, junto con el átomo de nitrógeno a cual los mismos están unidos representa un heterocicloalquilo opcionalmente sustituido o un heteroarilo opcionalmente sustituido;R4, R5 y R9 son en cada caso, independientemente, -H o un alquilo C1-6 ; y el anillo A se sustituye opcionalmente con uno o más sustituyentes seleccionados del grupo que consiste de a) un halo; b) un grupo alquilo C1-6 opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo que consiste de el hidroxilo, halo, y NR6R7; c) un grupo alcoxilo C1-6 opcionalmente sustituido con uno o más sustituyentes seleccionado del grupo que consiste de hidroxilo, halo, -NR6R7, un fenilo opcionalmente sustituido, y -NR17C(O)R19, con la condición que los sustituyentes no están unidos al carbono a que se une el oxígeno del grupo alcoxilo; d) un fenoxilo opcionalmente sustituido; e) hidroxilo; f) un grupo de la fórmula -C(O)R12 en donde R12 es un hidroxilo, un alcoxilo C1-6 o -NR13R14; g) un grupo de la fórmula NR17R18; h) un grupo de la fórmula -NR17C(O)R19; i) nitro; j) aralquilo opcionalmente sustituido; k) ciano; y l) un grupo alquenilo C2-4 o un grupo alquinilo C2-4 cada uno de los cuales es opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo que consiste de un grupo alquilo C1-6, un grupo alcoxilo C1-6 y un halo;R6 y R7, son cada uno, independientemente, -H, un grupo alquilo C1-6 opcionalmente sustituido, un cicloalquilo opcionalmente sustituido, un arilo opcionalmente sustituidos, un heteroarilo opcionalmente sustituido, un heterocicloalquilo opcionalmente sustituido, un cicloalquilalquilo opcionalmente sustituido, un aralquilo opcionalmente sustituido, un heteroaralquilo opcionalmente sustituido, o un heterocicloalquilalquilo opcionalmente sustituido; oR6 y R7 junto con el átomo de nitrógeno al cual éstos están unidos representan un heterocicloalquilo opcionalmente sustituido o un heteroarilo opcionalmente sustituido; R13, y R14 son cada uno, independientemente, -H, un grupo alquilo C1-6 opcionalmente sustituido, un cicloalquilo opcionalmente sustituido, un arilo opcionalmente sustituidos, un heteroarilo opcionalmente sustituido, un heterocicloalquilo opcionalmente sustituido, un cicloalquilalquilo opcionalmente sustituido, un aralquilo opcionalmente sustituido, un heteroaralquilo opcionalmente sustituido, o un heterocicloalquilalquilo opcionalmente sustituido; oR13, y R14 junto con el átomo de nitrógeno al cual éstos están unidos representan un heterocicloalquilo opcionalmente sustituido o un heteroarilo opcionalmente sustituido;R17 y R18 son cada uno, independientemente, seleccionado del grupo que consiste de -H, un grupo alquilo C1-2, un grupo cicloalquilo C3-12, y fenilo; yR19 es -H, un grupo alquilo C1-12 opcionalmente sustituido, un grupo cicloalquilo C3-12 opcionalmente sustituidos, un fenilo opcionalmente sustituido o un aralquilo opcionalmente sustituido.Teniendo en cuenta que B es un arilo, piridilo, tienilo, furilo o pirrolilo, entonces el anillo A es substituido con al menos un substituyente seleccionado del grupo que consiste de un grupo C1-6 alquil el cual es substituido con -NR6´R7´ un alcoxi C1-6 el cual es substituido con un grupo de fórmula -NR17C(O)R19 o un fenilo opcionalmente substituido, y un grupo de fórmula: - 3 -C (O) NR13' R14.R0' y R7 son cada uno independientes-H un cicloalquilo opcionalmente substituido un arilo opcionalmente substituido un heteroarilo opcionalmente substituido, un heterocicloalquilo opcionalmente substituido un cicloalquilalquilo opcionalmente substituido, un aralquilo opcionalmente substituido y un heteroaralquilo opcionalmente substituido un heterocicloalquilalquilo teniendo en cuenta que al menos uno de R9' o R7' no es H y queR13' y R14' son cada uno independientes de H, un cicloalquilo opcionalmente substituido, un naftilo opcionalmente substituido, un heteroarilo opcionalmente substituido, un heterocicloalquilo opcionalmente substituido, un cicloalquilalquilo opcionalmente substituido, un aralquilo opcionalmente substituido, un heteroaralquilo opcionalmente substituido, un heterocicloalquilalquilo opcionalmente substituido teniendo en cuenta que R13' o R14' no es H.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US09/573,366 US6462036B1 (en) | 1998-11-06 | 2000-05-17 | Tricyclic pyrazole derivatives |
Publications (1)
Publication Number | Publication Date |
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CO5290256A1 true CO5290256A1 (es) | 2003-06-27 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CO01039467A CO5290256A1 (es) | 2000-05-17 | 2001-05-17 | Derivados pirazol triciclicos |
Country Status (11)
Country | Link |
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US (1) | US6462036B1 (es) |
EP (1) | EP1289525A2 (es) |
JP (1) | JP2003533514A (es) |
AR (1) | AR029090A1 (es) |
AU (1) | AU2001263272A1 (es) |
CA (1) | CA2409225A1 (es) |
CO (1) | CO5290256A1 (es) |
MX (1) | MXPA02011320A (es) |
PE (1) | PE20011263A1 (es) |
UY (1) | UY26713A1 (es) |
WO (1) | WO2001087846A2 (es) |
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AU9691198A (en) | 1997-10-06 | 1999-04-27 | Basf Aktiengesellschaft | Indeno{1,2-c}-, naphtho{1,2-c}- and benzo{6,7}cyclohepta{1,2-c}pyrazole derivatives |
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-
2000
- 2000-05-17 US US09/573,366 patent/US6462036B1/en not_active Expired - Lifetime
-
2001
- 2001-05-17 UY UY26713A patent/UY26713A1/es not_active Application Discontinuation
- 2001-05-17 EP EP01937553A patent/EP1289525A2/en not_active Withdrawn
- 2001-05-17 JP JP2001584242A patent/JP2003533514A/ja not_active Withdrawn
- 2001-05-17 CO CO01039467A patent/CO5290256A1/es not_active Application Discontinuation
- 2001-05-17 PE PE2001000440A patent/PE20011263A1/es not_active Application Discontinuation
- 2001-05-17 MX MXPA02011320A patent/MXPA02011320A/es unknown
- 2001-05-17 WO PCT/US2001/016153 patent/WO2001087846A2/en not_active Application Discontinuation
- 2001-05-17 AR ARP010102343A patent/AR029090A1/es unknown
- 2001-05-17 AU AU2001263272A patent/AU2001263272A1/en not_active Abandoned
- 2001-05-17 CA CA002409225A patent/CA2409225A1/en not_active Abandoned
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AR029090A1 (es) | 2003-06-04 |
WO2001087846A3 (en) | 2002-03-21 |
US6462036B1 (en) | 2002-10-08 |
PE20011263A1 (es) | 2001-12-11 |
MXPA02011320A (es) | 2004-09-10 |
EP1289525A2 (en) | 2003-03-12 |
AU2001263272A1 (en) | 2001-11-26 |
CA2409225A1 (en) | 2001-11-22 |
UY26713A1 (es) | 2001-12-28 |
WO2001087846A2 (en) | 2001-11-22 |
JP2003533514A (ja) | 2003-11-11 |
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