CO5261557A1 - Formulacion farmaceutica que comprende 9-[2[[bis[pivaloiloxi metil]fosfono]metoxi]etil]adenina y un excipiente alcalino - Google Patents
Formulacion farmaceutica que comprende 9-[2[[bis[pivaloiloxi metil]fosfono]metoxi]etil]adenina y un excipiente alcalinoInfo
- Publication number
- CO5261557A1 CO5261557A1 CO99077816A CO99077816A CO5261557A1 CO 5261557 A1 CO5261557 A1 CO 5261557A1 CO 99077816 A CO99077816 A CO 99077816A CO 99077816 A CO99077816 A CO 99077816A CO 5261557 A1 CO5261557 A1 CO 5261557A1
- Authority
- CO
- Colombia
- Prior art keywords
- adenine
- bis
- ethyl
- pivaloiloxi
- metoxi
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Abstract
Una composición que comprende 9-[2-[[bis[(pivaloiloxi)metiI]fosfono]metoxi]etiI]adenina y un excipiente alcalino.2Un método para estabilizar 9-[2-[[bis[(pivaloiloxi)metil]fosfono]metoxi]etil]adenina que comprende mezclar la 9-[2-[[bis[(pivaloiloxi)metil]fosfono]metoxi]etil]adenina con un excipiente alcalino. <EMI FILE="99077816_1" ID="1" IMF=JPEG >
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11240398P | 1998-12-15 | 1998-12-15 | |
US09/211,613 US6635278B1 (en) | 1998-12-15 | 1998-12-15 | Pharmaceutical formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5261557A1 true CO5261557A1 (es) | 2003-03-31 |
Family
ID=26809911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO99077816A CO5261557A1 (es) | 1998-12-15 | 1999-12-13 | Formulacion farmaceutica que comprende 9-[2[[bis[pivaloiloxi metil]fosfono]metoxi]etil]adenina y un excipiente alcalino |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP1140114B1 (es) |
JP (1) | JP4750946B2 (es) |
KR (1) | KR100624214B1 (es) |
CN (2) | CN100361664C (es) |
AR (1) | AR021670A1 (es) |
AT (1) | ATE298576T1 (es) |
AU (1) | AU759869B2 (es) |
BR (1) | BRPI9916820B8 (es) |
CA (1) | CA2355239C (es) |
CO (1) | CO5261557A1 (es) |
DE (1) | DE69926012T2 (es) |
ES (1) | ES2245130T3 (es) |
HK (1) | HK1040488A1 (es) |
ID (1) | ID30032A (es) |
MY (1) | MY126526A (es) |
NZ (1) | NZ511855A (es) |
TR (1) | TR200101746T2 (es) |
TW (1) | TWI230618B (es) |
WO (1) | WO2000035460A2 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2536972T5 (es) * | 2000-07-21 | 2022-04-06 | Gilead Sciences Inc | Profármacos de análogos de nucleótidos de fosfonato y métodos para seleccionar y preparar los mismos |
KR20040028947A (ko) * | 2001-07-31 | 2004-04-03 | 하. 룬트벡 아크티에 셀스카브 | 에시탈로프람 함유 결정 조성물 |
AU2003284800A1 (en) | 2002-11-12 | 2004-06-03 | Tianjin Kinsly Pharmaceutical Co., Ltd. | A new crystal form of adefovir dipivoxil and its composition |
EP1635847B1 (en) | 2003-06-13 | 2019-07-31 | IDH Holding ApS | Treatment of symptoms associated with bacterial vaginosis |
ITMI20071594A1 (it) | 2007-08-02 | 2009-02-03 | Solmag Spa | Forma cristallina monoidrata di adefovir dipivoxil |
KR20100031045A (ko) * | 2008-09-11 | 2010-03-19 | 씨제이제일제당 (주) | 아데포비어 디피복실의 정제방법 |
CN104173356A (zh) * | 2008-09-17 | 2014-12-03 | Cj第一制糖株式会社 | 肝适能固态分散物、包括其的药的组成物以及其制备方法 |
KR101089620B1 (ko) * | 2009-07-20 | 2011-12-06 | 경희대학교 산학협력단 | 무수결정형 아데포비어 디피복실 및 이온성 액체를 사용한 이의 제조 방법 |
EP2343056A1 (en) | 2009-12-30 | 2011-07-13 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Producing stable adefovir dipivoxil solid dispersions |
AU2015384801B2 (en) | 2015-03-04 | 2022-01-06 | Eisai R&D Management Co., Ltd. | Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer |
CN108883091A (zh) * | 2015-12-22 | 2018-11-23 | X4 制药有限公司 | 用于治疗免疫缺陷病的方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58201726A (ja) * | 1982-05-18 | 1983-11-24 | Meiji Seika Kaisha Ltd | 安定な製剤の製造法 |
CS263952B1 (en) * | 1985-04-25 | 1989-05-12 | Holy Antonin | Remedy with antiviral effect |
US4704365A (en) * | 1986-02-24 | 1987-11-03 | Abbott Laboratories | Composition and method for stabilization of dinucleotides |
CA2035841C (en) * | 1990-02-22 | 1996-02-13 | Harry B. Demopoulos | Storage-stable glucosamine sulphate oral dosage forms and methods for their manufacture |
ATE167679T1 (de) * | 1990-09-14 | 1998-07-15 | Acad Of Science Czech Republic | Wirkstoffvorläufer von phosphonaten |
JPH0825905B2 (ja) * | 1990-11-20 | 1996-03-13 | 武田薬品工業株式会社 | 医薬固形組成物用安定化剤および安定化方法 |
HU9203780D0 (en) * | 1991-12-12 | 1993-03-29 | Sandoz Ag | Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them |
ATE178794T1 (de) * | 1993-01-19 | 1999-04-15 | Warner Lambert Co | Stabilisierte, oral anzuwendende zusammensetzung enthaltend die verbindung ci-981 und verfahren |
US5817336A (en) * | 1993-04-02 | 1998-10-06 | Orion-Yhtyma Oy | Composition containing selegiline |
JP2974550B2 (ja) * | 1993-06-01 | 1999-11-10 | ビオフェルミン製薬株式会社 | 経口投与用固体組成物 |
US5919776A (en) * | 1996-12-20 | 1999-07-06 | Merck & Co., Inc. | Substituted aminoquinolines as modulators of chemokine receptor activity |
JP2762998B2 (ja) * | 1997-04-25 | 1998-06-11 | 武田薬品工業株式会社 | 医薬固形組成物用安定化剤および安定化方法 |
JPH114666A (ja) * | 1997-06-17 | 1999-01-12 | Otsuka Pharmaceut Co Ltd | マグネシウム補給発泡剤組成物 |
CA2596320C (en) * | 1997-07-25 | 2008-12-23 | Gilead Sciences, Inc. | Nucleotide analog compositions |
-
1999
- 1999-12-10 TW TW088121700A patent/TWI230618B/zh not_active IP Right Cessation
- 1999-12-13 CO CO99077816A patent/CO5261557A1/es active IP Right Grant
- 1999-12-14 CN CNB2005100659791A patent/CN100361664C/zh not_active Expired - Lifetime
- 1999-12-14 MY MYPI99005427A patent/MY126526A/en unknown
- 1999-12-14 EP EP99967310A patent/EP1140114B1/en not_active Expired - Lifetime
- 1999-12-14 AT AT99967310T patent/ATE298576T1/de not_active IP Right Cessation
- 1999-12-14 TR TR2001/01746T patent/TR200101746T2/xx unknown
- 1999-12-14 ID IDW00200101527A patent/ID30032A/id unknown
- 1999-12-14 KR KR1020017007531A patent/KR100624214B1/ko active IP Right Grant
- 1999-12-14 ES ES99967310T patent/ES2245130T3/es not_active Expired - Lifetime
- 1999-12-14 NZ NZ511855A patent/NZ511855A/en not_active IP Right Cessation
- 1999-12-14 DE DE69926012T patent/DE69926012T2/de not_active Expired - Lifetime
- 1999-12-14 AU AU23613/00A patent/AU759869B2/en not_active Expired
- 1999-12-14 JP JP2000587780A patent/JP4750946B2/ja not_active Expired - Lifetime
- 1999-12-14 CN CNB998145289A patent/CN1202829C/zh not_active Expired - Lifetime
- 1999-12-14 AR ARP990106372A patent/AR021670A1/es active IP Right Grant
- 1999-12-14 CA CA002355239A patent/CA2355239C/en not_active Expired - Lifetime
- 1999-12-14 WO PCT/US1999/029626 patent/WO2000035460A2/en active IP Right Grant
- 1999-12-14 BR BRPI9916820A patent/BRPI9916820B8/pt not_active IP Right Cessation
-
2002
- 2002-02-11 HK HK02101060A patent/HK1040488A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ID30032A (id) | 2001-11-01 |
HK1040488A1 (en) | 2002-06-14 |
CN1202829C (zh) | 2005-05-25 |
BRPI9916820B8 (pt) | 2023-04-25 |
TWI230618B (en) | 2005-04-11 |
CA2355239A1 (en) | 2000-06-22 |
AR021670A1 (es) | 2002-07-31 |
JP4750946B2 (ja) | 2011-08-17 |
BRPI9916820A2 (pt) | 2001-10-30 |
CN1682743A (zh) | 2005-10-19 |
CN1330547A (zh) | 2002-01-09 |
BRPI9916820B1 (pt) | 2018-04-03 |
WO2000035460A2 (en) | 2000-06-22 |
TR200101746T2 (tr) | 2001-12-21 |
KR100624214B1 (ko) | 2006-09-18 |
CN100361664C (zh) | 2008-01-16 |
ATE298576T1 (de) | 2005-07-15 |
DE69926012D1 (de) | 2005-08-04 |
EP1140114A2 (en) | 2001-10-10 |
NZ511855A (en) | 2003-07-25 |
EP1140114B1 (en) | 2005-06-29 |
CA2355239C (en) | 2008-03-18 |
DE69926012T2 (de) | 2006-05-04 |
WO2000035460A3 (en) | 2000-11-09 |
ES2245130T3 (es) | 2005-12-16 |
JP2002532429A (ja) | 2002-10-02 |
AU2361300A (en) | 2000-07-03 |
AU759869B2 (en) | 2003-05-01 |
KR20010080765A (ko) | 2001-08-22 |
MY126526A (en) | 2006-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Application granted |