CO5180638A1 - Amidas de acidos carboxilicos, su preparacion y su empleo como medicamentos - Google Patents
Amidas de acidos carboxilicos, su preparacion y su empleo como medicamentosInfo
- Publication number
- CO5180638A1 CO5180638A1 CO00058854A CO00058854A CO5180638A1 CO 5180638 A1 CO5180638 A1 CO 5180638A1 CO 00058854 A CO00058854 A CO 00058854A CO 00058854 A CO00058854 A CO 00058854A CO 5180638 A1 CO5180638 A1 CO 5180638A1
- Authority
- CO
- Colombia
- Prior art keywords
- group
- alkyl
- optionally substituted
- amino
- substituted
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 22
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 5
- 239000000460 chlorine Substances 0.000 abstract 5
- 229910052801 chlorine Inorganic materials 0.000 abstract 5
- 239000011737 fluorine Substances 0.000 abstract 5
- 229910052731 fluorine Inorganic materials 0.000 abstract 5
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 4
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- -1 phenyl C1-3 alkoxy Chemical group 0.000 abstract 4
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 abstract 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006163 5-membered heteroaryl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000006842 cycloalkyleneimino group Chemical group 0.000 abstract 1
- 125000006576 di-(C1-C3-alkyl)-aminocarbonyl group Chemical group 0.000 abstract 1
- 125000005549 heteroarylene group Chemical group 0.000 abstract 1
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
- 125000000879 imine group Chemical group 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004957 naphthylene group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000004962 physiological condition Effects 0.000 abstract 1
- 125000005550 pyrazinylene group Chemical group 0.000 abstract 1
- 125000005551 pyridylene group Chemical group 0.000 abstract 1
- 125000005576 pyrimidinylene group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000005557 thiazolylene group Chemical group 0.000 abstract 1
- 125000005556 thienylene group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Abstract
1. Amidas de ácidos carboxílicos de la fórmula general (I):<EMI FILE="00058854_1" ID="1" IMF=JPEG >en la queuno de los radicales m ó n significa el número 0 y el otro de los radicales m ó n significa el número 1,Ar significa un grupo fenileno o naftileno, eventualmente sustituido con un átomo de flúor, cloro o bromo, con un grupo trifluorometilo, alquilo C1-3, hidroxi, alcoxi C1-3, fenil-alcoxi C1-3, amino, alquil C1-3-amino o di-(alquil C1-3)-amino, pudiendo estar sustituido el grupo fenileno con otro átomo de flúor, cloro o bromo o con otro grupo alquilo C1-3, significa un grupo tienileno, tiazolileno, piridinileno, pirimidinileno, pirazinileno o piridazinileno, eventualmente sustituido en el esqueleto de carbonos con un grupo alquilo C1-3, R1 significa un grupo alquilo C1-3, eventualmente sustituido con un grupo amino, alquil C1-3-amino, di-(alquil C1-3)- amino, fenilo, naftilo, heteroarilo o cicloalquilenimino de a 4 a 7 miembros, significa un grupo cicloalquilo C3-7, que en posición 1 está sustituido con un grupo cicloalquileniminocarbonilo de 5 a 7 miembros, significa un grupo amino, alquil C1-5-amino, cicloalquil C5-7-amino o fenil-alquil C1-3-amino que, en cada caso en el átomo de nitrógeno de la amina, puede estar sustituido con un grupo benzoilo o con un grupo alquilo C1-3 o alquil C1-3-carbonilo, eventualmente sustituido en la parte de alquilo C1-3 con un grupo carboxi,significa un grupo cicloalquileniminocarbonilo o cicloalquileniminosulfonilo de 4 a 7 miembros, eventualmente sustituido con un grupo alquilo C1-3, significa un grupo aminosulfonilo, eventualmente sustituido con uno o dos grupos alquilo C1-3,significa un grupo fenilo, eventualmente sustituido con un átomo de flúor , cloro o bromo, con un grupo trifluorometilo, aminosulfonilo, alquilo C1-3 o alcoxi C1-3 que, adicionalmente, puede estar sustituido con un átomo de flúor, cloro o bromo, con un grupo trifluorometilo, alquilo C1-3 o alcoxi C1-3,significa un grupo alcoxi, fenil-alcoxi C1-3, heteroariloxi o heteroariloxi-alcoxi C1-3, en el que la parte de alcoxi, en cada caso en posición 2 ó 3, también puede estar sustituida con un grupo amino, alquil C1-3 o di(alquil C1-3)-amino,significa un grupo cicloalcoxi C3-7, pudiendo estar reemplazado el grupo metileno en posición 3 o 4 en un grupo cicloalcoxi C5-7 con un grupo -NH, pudiendo estar sustituido el grupo -NHcon un grupo alquilo C1-3 que, en posición 2 ó 3, también puede estar sustituido con un grupo amino, - 2 - alquil C1-3-amino o di-(alquil C1-3)-amino, con un grupo alquil C1-3-carbonilo, arilcarbonilo o arilfulfonilo, o con un grupo aminocarbonilo, alquil C1-3-aminocarbonilo o di(alquil C1-3)-aminocarbonilo, en los que en cada caso el átomo de oxígeno del grupo carbonilo está reemplazado por un grupo imino, R2 significa un átomo de hidrógeno, flúor, cloro o bromo, un grupo alquilo C1-3, hidroxi o alcoxi C1-3,R3 significa un átomo de hidrógeno o un grupo alquilo C1-3,R4 significa un átomo de hidrógeno o un grupo alquilo C1-3, eventualmente sustituido con un grupo carboxi, yR5 significa un grupo ciano o un grupo amidino, eventualmente sustituido con uno o dos grupos alquilo C1-3,por los grupos heteroarilo precedentemente mencionados se ha entender un grupo heteroarilo de 5 miembros, eventualmente sustituido con un grupo alquilo C1-3, que en la parte heteroaromática contieneun grupo imino, eventualmente sustituido con un grupo alquilo C1-3, y un átomo de oxígeno o azufre,un grupo ímino, eventualmente sustituido con un grupo alquilo C1-3, un átomo de oxígeno, azufre o nitrógeno,un grupo imino, eventualmente sustituido con un grupo alquilo C1-3, y dos átomos de nitrógeno, oun átomo de oxígeno o azufre y dos átomos de nitrógeno, o un grupo heteroarileno de 6 miembros, eventualmente sustituido con un grupo alquilo C1-3, que en la parte heteroaromática contieneuno o dos átomos de nitrógeno, los grupos carboxi mencionados en la definición en de los radicales precedentemente mencionados pueden estar reemplazados por un grupo transformable in vivo en un grupo carboxi o por un grupo cargado negativamente en condiciones fisiológicas, ylos grupos amino e imino mencionados en la definición de los radicales precedentemente mencionados pueden estar sustituidos con un radical separable in vivo,sus isómeros y sus sales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19937494A DE19937494A1 (de) | 1999-08-07 | 1999-08-07 | Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel |
DE10025663A DE10025663A1 (de) | 2000-05-24 | 2000-05-24 | Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5180638A1 true CO5180638A1 (es) | 2002-07-30 |
Family
ID=26005812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO00058854A CO5180638A1 (es) | 1999-08-07 | 2000-08-04 | Amidas de acidos carboxilicos, su preparacion y su empleo como medicamentos |
Country Status (11)
Country | Link |
---|---|
US (1) | US7425641B2 (es) |
EP (1) | EP1206446B1 (es) |
JP (1) | JP3853653B2 (es) |
AT (1) | ATE267803T1 (es) |
AU (1) | AU6834000A (es) |
CA (1) | CA2380986C (es) |
CO (1) | CO5180638A1 (es) |
DE (1) | DE50006615D1 (es) |
MX (1) | MXPA02001329A (es) |
UY (1) | UY26273A1 (es) |
WO (1) | WO2001010823A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3853653B2 (ja) | 1999-08-07 | 2006-12-06 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | カルボン酸アミド、その調製法及び医薬組成物としてのその使用 |
MXPA03006648A (es) * | 2001-02-02 | 2003-10-15 | Boehringer Ingelheim Pharma | Compuestos antitombroticos, su preparacion y su utilizacion como medicamentos. |
MXPA03006580A (es) * | 2001-02-02 | 2003-09-22 | Boehringer Ingelheim Pharma | Amidas de acido carboxilico, su produccion y su uso como medicamentos. |
DE10124867A1 (de) * | 2001-05-22 | 2002-11-28 | Boehringer Ingelheim Pharma | Substituierte Aryl- und Heteroarylderivate, deren Herstellung und deren Verwendung als Arzneimittel |
US7005437B2 (en) | 2001-05-22 | 2006-02-28 | Boehringer Ingelheim Pharma Kg | Substituted aryl and heteroaryl derivatives, the preparation thereof and the use therof as pharmaceutical compositions |
CN1703395A (zh) * | 2002-08-09 | 2005-11-30 | 特兰斯泰克制药公司 | 芳基和杂芳基化合物以及调节凝血的方法 |
WO2005014534A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
US7208601B2 (en) | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
JP2007501844A (ja) | 2003-08-08 | 2007-02-01 | トランス テック ファーマ,インコーポレイテッド | アリール及びヘテロアリール化合物、組成物並びに使用方法 |
TWI350168B (en) * | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
WO2008030448A1 (en) * | 2006-09-07 | 2008-03-13 | Millennium Pharmaceuticals, Inc. | Phenethylamide derivatives with kinase inhibitory activity |
CA2669915C (en) | 2006-11-17 | 2012-02-07 | Pfizer Inc. | Substituted bicyclocarboxyamide compounds |
GB0815781D0 (en) * | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD142804A3 (de) * | 1977-11-07 | 1980-07-16 | Wagner Guenter | Verfahren zur herstellung von na-alkyl-bzw.na-aryl-sulfonylierten omega-amidinophenyl-alpha-aminoalkylcarbonsaeureamiden |
YU46706B (sh) | 1987-09-05 | 1994-04-05 | Hokuriku Pharmaceutical Co. Ltd. | Postupak za dobijanje amidnih jedinjenja |
JPH0193568A (ja) | 1987-10-05 | 1989-04-12 | Hokuriku Seiyaku Co Ltd | アミド化合物、及びそれを有効成分とする消化管運動賦活剤 |
JPH04249551A (ja) | 1991-01-07 | 1992-09-04 | Sumitomo Chem Co Ltd | ゴム組成物 |
US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
EP0975608B1 (en) | 1997-04-15 | 2005-06-15 | Genentech, Inc. | Halo-alkoxycarbonyl prodrugs |
DE19937494A1 (de) | 1999-08-07 | 2001-02-08 | Boehringer Ingelheim Pharma | Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel |
JP3853653B2 (ja) | 1999-08-07 | 2006-12-06 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | カルボン酸アミド、その調製法及び医薬組成物としてのその使用 |
MXPA03006580A (es) | 2001-02-02 | 2003-09-22 | Boehringer Ingelheim Pharma | Amidas de acido carboxilico, su produccion y su uso como medicamentos. |
US20020151595A1 (en) * | 2001-02-02 | 2002-10-17 | Ries Uwe Joerg | Carboxylic acid amides having antithrombotic activity |
WO2003035602A1 (fr) | 2001-10-25 | 2003-05-01 | Sankyo Company, Limited | Modulateurs lipidiques |
-
2000
- 2000-08-02 JP JP2001515290A patent/JP3853653B2/ja not_active Expired - Fee Related
- 2000-08-02 AT AT00956375T patent/ATE267803T1/de not_active IP Right Cessation
- 2000-08-02 DE DE50006615T patent/DE50006615D1/de not_active Expired - Lifetime
- 2000-08-02 AU AU68340/00A patent/AU6834000A/en not_active Abandoned
- 2000-08-02 WO PCT/EP2000/007457 patent/WO2001010823A1/de active IP Right Grant
- 2000-08-02 MX MXPA02001329A patent/MXPA02001329A/es active IP Right Grant
- 2000-08-02 EP EP00956375A patent/EP1206446B1/de not_active Expired - Lifetime
- 2000-08-02 CA CA002380986A patent/CA2380986C/en not_active Expired - Fee Related
- 2000-08-04 CO CO00058854A patent/CO5180638A1/es not_active Application Discontinuation
- 2000-08-04 UY UY26273A patent/UY26273A1/es not_active Application Discontinuation
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2004
- 2004-09-10 US US10/938,804 patent/US7425641B2/en not_active Expired - Lifetime
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CA2380986A1 (en) | 2001-02-15 |
ATE267803T1 (de) | 2004-06-15 |
JP3853653B2 (ja) | 2006-12-06 |
AU6834000A (en) | 2001-03-05 |
EP1206446A1 (de) | 2002-05-22 |
JP2003506432A (ja) | 2003-02-18 |
DE50006615D1 (de) | 2004-07-01 |
MXPA02001329A (es) | 2002-08-12 |
UY26273A1 (es) | 2001-05-31 |
WO2001010823A1 (de) | 2001-02-15 |
US7425641B2 (en) | 2008-09-16 |
EP1206446B1 (de) | 2004-05-26 |
US20050065346A1 (en) | 2005-03-24 |
CA2380986C (en) | 2009-10-20 |
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