CO5160248A1 - Metodo para tratar copd - Google Patents
Metodo para tratar copdInfo
- Publication number
- CO5160248A1 CO5160248A1 CO00014625A CO00014625A CO5160248A1 CO 5160248 A1 CO5160248 A1 CO 5160248A1 CO 00014625 A CO00014625 A CO 00014625A CO 00014625 A CO00014625 A CO 00014625A CO 5160248 A1 CO5160248 A1 CO 5160248A1
- Authority
- CO
- Colombia
- Prior art keywords
- rolipram
- pde4
- inhibitor
- pde
- ratio
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/30—Copper compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un método para la profilaxis o tratamiento de COPD en un ser humano, administrando un inhibidor específico de PDE 4 que inhibe preferentemente la forma catalítica de PDE 4 que une R-rolipram con una baja afinidad, cuyo método comprende administrar a un paciente que lo necesite una cantidad eficaz de un compuesto que tiene una relación de IC50 de aproximadamente 0,1 o más en relación con la IC50 para la forma de PDE 4 que une R-rolipram con una alta afinidad dividida por la IC50 para la forma catalítica que une R-rolipram con una baja afinidad, excluyendo cis-[4-ciano-4-(3-ciclopentiloxi-4-metoxifenil)ciclohexan-1-carboxilato].La fabricación de un medicamento para la profilaxis o para tratar COPD que comprende mezclar un inhibidor específico de PDE4 con un portador farmacéuticamente aceptable, en la que el inhibidor tiene una relación de IC50 de aproximadamente 0,1 o más en relación con la relación del valor de IC50 para competir con la unión de 1 nM, de [3H]R-rolipram a una forma de PDE4 que une rolipram con alta afinidad comparado con el valor de IC50 para inhibir la actividad catalítica de PDE4 de una forma que une rolipram con baja afinidad utilizando l3H]-cAMP 1 µM como substrato, excluyendo cis-[4-ciano-4-(3-ciclopentiloxi-4-metoxifenil)ciclohexan-1-carboxilato].
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12231599P | 1999-03-01 | 1999-03-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5160248A1 true CO5160248A1 (es) | 2002-05-30 |
Family
ID=22401990
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO00014625A CO5160248A1 (es) | 1999-03-01 | 2000-03-01 | Metodo para tratar copd |
Country Status (30)
Country | Link |
---|---|
US (1) | US6670394B1 (es) |
EP (1) | EP1156799A4 (es) |
JP (1) | JP2002538114A (es) |
KR (1) | KR20010102459A (es) |
CN (1) | CN1349403A (es) |
AP (1) | AP2001002248A0 (es) |
AR (1) | AR042369A1 (es) |
AU (1) | AU772583B2 (es) |
BG (1) | BG105953A (es) |
BR (1) | BR0008603A (es) |
CA (1) | CA2366036A1 (es) |
CO (1) | CO5160248A1 (es) |
CZ (1) | CZ20013149A3 (es) |
DZ (1) | DZ3019A1 (es) |
EA (1) | EA200100930A1 (es) |
HK (1) | HK1043935A1 (es) |
HU (1) | HUP0200288A3 (es) |
ID (1) | ID29888A (es) |
IL (1) | IL144992A0 (es) |
MA (1) | MA25522A1 (es) |
NO (1) | NO20014222L (es) |
NZ (1) | NZ513695A (es) |
OA (1) | OA11842A (es) |
PE (1) | PE20001505A1 (es) |
PL (1) | PL352816A1 (es) |
SK (1) | SK12372001A3 (es) |
TR (1) | TR200102514T2 (es) |
UY (1) | UY26040A1 (es) |
WO (1) | WO2000051598A1 (es) |
ZA (1) | ZA200107186B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2362101A (en) * | 2000-05-12 | 2001-11-14 | Astrazeneca Ab | Treatment of chronic obstructive pulmonary disease |
US20040005995A1 (en) * | 2001-07-26 | 2004-01-08 | Edelson Jeffrey D | Method for reducing exacerbations associated with copd |
AR029984A1 (es) * | 2000-07-27 | 2003-07-23 | Smithkline Beecham Corp | Metodo para reducir las exacerbaciones asociadas copd ambito |
WO2002088079A2 (en) * | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
AR039385A1 (es) | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
ATE447555T1 (de) | 2003-03-10 | 2009-11-15 | Nycomed Gmbh | Neues verfahren zur herstellung vonroflumilast |
JPWO2004087148A1 (ja) * | 2003-03-31 | 2006-06-29 | 協和醗酵工業株式会社 | 肺疾患の治療および/または予防剤 |
JPWO2005056009A1 (ja) * | 2003-12-12 | 2007-07-05 | 協和醗酵工業株式会社 | 肺疾患治療剤 |
MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
EP2258350B1 (en) | 2005-03-16 | 2014-12-24 | Takeda GmbH | Taste masked dosage form containing roflumilast |
TW200804383A (en) | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3251587B2 (ja) * | 1992-04-02 | 2002-01-28 | スミスクライン・ビーチャム・コーポレイション | 炎症疾患の治療および腫瘍壊死因子の産生阻害に有用な化合物 |
HU225869B1 (en) * | 1992-04-02 | 2007-11-28 | Smithkline Beecham Corp | Compounds with antiallergic and antiinflammatory activity and pharmaceutical compns. contg. them |
JPH08511805A (ja) | 1993-06-18 | 1996-12-10 | スミスクライン・ビーチャム・コーポレイション | 化合物 |
US5728705A (en) * | 1993-10-04 | 1998-03-17 | The Trustees Of Columbia University In The City Of New York | Method of inducing vasorelaxation to treat pulmonary hypertension |
PL314605A1 (en) * | 1993-11-26 | 1996-09-16 | Pfizer | Isoxazolin compounds as anti-inflammatory agents |
UY25338A1 (es) | 1998-01-07 | 2001-08-27 | Smithkline Beecham Corp | Método para tratar copd |
-
2000
- 2000-02-27 DZ DZ000038A patent/DZ3019A1/xx active
- 2000-02-28 AR ARP000100863A patent/AR042369A1/es not_active Application Discontinuation
- 2000-02-28 UY UY26040A patent/UY26040A1/es unknown
- 2000-02-29 PE PE2000000165A patent/PE20001505A1/es not_active Application Discontinuation
- 2000-03-01 IL IL14499200A patent/IL144992A0/xx unknown
- 2000-03-01 OA OA1200100226A patent/OA11842A/en unknown
- 2000-03-01 CA CA002366036A patent/CA2366036A1/en not_active Abandoned
- 2000-03-01 US US09/914,703 patent/US6670394B1/en not_active Expired - Fee Related
- 2000-03-01 CO CO00014625A patent/CO5160248A1/es unknown
- 2000-03-01 EA EA200100930A patent/EA200100930A1/ru unknown
- 2000-03-01 AP APAP/P/2001/002248A patent/AP2001002248A0/en unknown
- 2000-03-01 CZ CZ20013149A patent/CZ20013149A3/cs unknown
- 2000-03-01 SK SK1237-2001A patent/SK12372001A3/sk unknown
- 2000-03-01 JP JP2000602066A patent/JP2002538114A/ja not_active Withdrawn
- 2000-03-01 WO PCT/US2000/005227 patent/WO2000051598A1/en not_active Application Discontinuation
- 2000-03-01 NZ NZ513695A patent/NZ513695A/en unknown
- 2000-03-01 KR KR1020017011096A patent/KR20010102459A/ko not_active Application Discontinuation
- 2000-03-01 BR BR0008603-7A patent/BR0008603A/pt not_active Application Discontinuation
- 2000-03-01 AU AU33869/00A patent/AU772583B2/en not_active Ceased
- 2000-03-01 PL PL00352816A patent/PL352816A1/xx not_active Application Discontinuation
- 2000-03-01 HU HU0200288A patent/HUP0200288A3/hu unknown
- 2000-03-01 ID IDW00200101869A patent/ID29888A/id unknown
- 2000-03-01 EP EP00912074A patent/EP1156799A4/en not_active Withdrawn
- 2000-03-01 CN CN00806912A patent/CN1349403A/zh active Pending
- 2000-03-01 TR TR2001/02514T patent/TR200102514T2/xx unknown
-
2001
- 2001-08-30 ZA ZA200107186A patent/ZA200107186B/en unknown
- 2001-08-31 NO NO20014222A patent/NO20014222L/no not_active Application Discontinuation
- 2001-09-03 MA MA26314A patent/MA25522A1/fr unknown
- 2001-09-26 BG BG105953A patent/BG105953A/xx unknown
-
2002
- 2002-05-16 HK HK02103723.6A patent/HK1043935A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU772583B2 (en) | 2004-04-29 |
WO2000051598A1 (en) | 2000-09-08 |
TR200102514T2 (tr) | 2002-04-22 |
HK1043935A1 (zh) | 2002-10-04 |
EP1156799A4 (en) | 2004-11-10 |
DZ3019A1 (fr) | 2005-05-20 |
SK12372001A3 (sk) | 2001-12-03 |
UY26040A1 (es) | 2000-09-29 |
OA11842A (en) | 2005-08-22 |
EP1156799A1 (en) | 2001-11-28 |
IL144992A0 (en) | 2002-06-30 |
NO20014222D0 (no) | 2001-08-31 |
BG105953A (en) | 2002-05-31 |
MA25522A1 (fr) | 2002-10-01 |
ZA200107186B (en) | 2002-08-30 |
HUP0200288A3 (en) | 2003-08-28 |
HUP0200288A2 (hu) | 2002-05-29 |
CZ20013149A3 (cs) | 2002-04-17 |
CN1349403A (zh) | 2002-05-15 |
US6670394B1 (en) | 2003-12-30 |
AR042369A1 (es) | 2005-06-22 |
CA2366036A1 (en) | 2000-09-08 |
AU3386900A (en) | 2000-09-21 |
PL352816A1 (en) | 2003-09-08 |
BR0008603A (pt) | 2001-12-26 |
AP2001002248A0 (en) | 2001-09-30 |
NZ513695A (en) | 2001-09-28 |
EA200100930A1 (ru) | 2002-02-28 |
PE20001505A1 (es) | 2001-02-08 |
ID29888A (id) | 2001-10-18 |
JP2002538114A (ja) | 2002-11-12 |
NO20014222L (no) | 2001-10-29 |
KR20010102459A (ko) | 2001-11-15 |
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