CO4970801A1 - Derivados de d-homo-9,10-secocolesta-23-in-3,25-diol - Google Patents

Derivados de d-homo-9,10-secocolesta-23-in-3,25-diol

Info

Publication number
CO4970801A1
CO4970801A1 CO98060009A CO98060009A CO4970801A1 CO 4970801 A1 CO4970801 A1 CO 4970801A1 CO 98060009 A CO98060009 A CO 98060009A CO 98060009 A CO98060009 A CO 98060009A CO 4970801 A1 CO4970801 A1 CO 4970801A1
Authority
CO
Colombia
Prior art keywords
secocolesta
homo
derivatives
diol
acne
Prior art date
Application number
CO98060009A
Other languages
English (en)
Inventor
Pierre Barbier
Franz Bauer
Peter Mohr
Muller Marc
Wolfgang Pirson
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO4970801A1 publication Critical patent/CO4970801A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/36—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.4.0) system, e.g. naphols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Derivados de D-homo-9, 10-secocolesta-23-in-3,25-diol defórmula I:en donde el enlace C-C de puntos del anillo D es opcional,C(R,R) es CH2 ó C=CH2 ,R1 es H, F ó OH,R2 y R3 son independientemente entre sí, alquilo de 1 a 4 átomos de carbono ó CF3 óC(R2 ,R3 ) es cicloalquilo de 3 a 6 átomos de carbono, dimetilsililo, terc-butil-difenilsililo o trimetilsililo.Los compuestos de la reivindicación 1 para emplear como agente terapéuticamente activo, en particular para el tratamiento de trastornos que dependen de la vitamina D, tales como la psoriasis, leucemia; acné y dermatitis seborreica; osteoporosis, hiperparatiroidismo que acompaña la insuficiencia renal; y la esclerosis múltiple.El compuesto de la reivindicación 1 para la elaboración de un medicamento para el tratamiento de trastornos que dependen de la vitamina D, tales como la psoriasis, leucemia; acné y dermatitis seborreica; osteoporosis, hiperparatiroidismo que acompaña la insuficiencia renal; y la esclerosis múltiple.
CO98060009A 1997-10-17 1998-10-15 Derivados de d-homo-9,10-secocolesta-23-in-3,25-diol CO4970801A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97118036 1997-10-17

Publications (1)

Publication Number Publication Date
CO4970801A1 true CO4970801A1 (es) 2000-11-07

Family

ID=8227488

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98060009A CO4970801A1 (es) 1997-10-17 1998-10-15 Derivados de d-homo-9,10-secocolesta-23-in-3,25-diol

Country Status (8)

Country Link
US (1) US5919986A (es)
AR (1) AR017339A1 (es)
AU (1) AU9750398A (es)
CO (1) CO4970801A1 (es)
MA (1) MA26554A1 (es)
PE (1) PE120899A1 (es)
WO (1) WO1999020605A1 (es)
ZA (1) ZA989431B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030191093A1 (en) * 2001-12-03 2003-10-09 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US20050101576A1 (en) * 2003-11-06 2005-05-12 Novacea, Inc. Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes
US20050026877A1 (en) * 2002-12-03 2005-02-03 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
CN1856251A (zh) * 2003-06-11 2006-11-01 诺瓦西股份有限公司 含活性维生素d化合物的药物组合物
US20050020546A1 (en) * 2003-06-11 2005-01-27 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
DK1993559T3 (en) 2006-02-03 2016-10-03 Opko Renal Llc Treatment of vitamin D deficiency and MALFUNCTION with 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3
ES2670029T3 (es) 2006-06-21 2018-05-29 Opko Ireland Global Holdings, Ltd. Terapia usando agente de repleción de la vitamina D y agente de reemplazo de la hormona de la vitamina D
KR101495578B1 (ko) 2007-04-25 2015-02-25 사이토크로마 인코포레이티드 비타민 ｄ 부족 및 결핍의 치료 방법
DK2481400T3 (da) 2007-04-25 2014-09-29 Opko Ip Holdings Ii Inc Orale præparater med kontrolleret frigivelse omfattende en vitamin D-forbindelse og en voksagtig bærer
MX339746B (es) 2009-01-27 2016-06-08 Berg Llc Vitamina d3 y análogos de la misma para aliviar efectos secundarios asociados con la quimioterapia.
JP5978130B2 (ja) 2009-08-14 2016-08-24 バーグ エルエルシー 脱毛症を治療するためのビタミンｄ３およびその類似体
CN105796530A (zh) 2010-03-29 2016-07-27 赛特克罗公司 用于降低甲状旁腺水平的方法和组合物
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
WO2014194133A1 (en) 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
IL290855B2 (en) 2016-03-28 2024-06-01 Eirgen Pharma Ltd Treatment methods using vitamin D

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
ATE141914T1 (de) * 1992-05-20 1996-09-15 Hoffmann La Roche Fluorierte analoge vitamins d3
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
CA2166898C (en) * 1993-07-09 2004-09-07 Roger Bouillon Novel structural analogues of vitamin d
US5384314B1 (en) * 1994-03-11 1997-08-05 Hoffmann La Roche 1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol
DE69606680T2 (de) * 1995-10-30 2000-08-17 F. Hoffmann-La Roche Ag, Basel 1-Alpha, 26-dihydroxy-D-homo-vitamin D3
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol

Also Published As

Publication number Publication date
MA26554A1 (fr) 2004-12-20
WO1999020605A1 (en) 1999-04-29
AR017339A1 (es) 2001-09-05
PE120899A1 (es) 1999-12-02
ZA989431B (en) 1999-04-19
AU9750398A (en) 1999-05-10
US5919986A (en) 1999-07-06

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