CO4970751A1 - COMPUESTOS INHIBIDORES SELECTIVOS DE LAS ENZIMAS DE cPLA2 Y COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN - Google Patents

COMPUESTOS INHIBIDORES SELECTIVOS DE LAS ENZIMAS DE cPLA2 Y COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN

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Publication number
CO4970751A1
CO4970751A1 CO98054714A CO98054714A CO4970751A1 CO 4970751 A1 CO4970751 A1 CO 4970751A1 CO 98054714 A CO98054714 A CO 98054714A CO 98054714 A CO98054714 A CO 98054714A CO 4970751 A1 CO4970751 A1 CO 4970751A1
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Colombia
Prior art keywords
carbon atoms
alkyl
integer
alkenyl
pharmaceutical compositions
Prior art date
Application number
CO98054714A
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English (en)
Inventor
Jacques Banville
Gai Yonghua
Johnson Graham
Fred Christopher Zusi
James R Burke
Original Assignee
Britol Myers Squibb Company
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Publication of CO4970751A1 publication Critical patent/CO4970751A1/es

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P19/00—Drugs for skeletal disorders
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    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
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    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
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    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/04—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
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    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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Abstract

La presente invención se dirige a compuestos trifluorometilcetonas inhibidores de la PLa2 citosólica, selectivos de la fórmula: en donde W es CH=CH, CH=N, O o S; R1 es alquilo de 1 a 6 átomos de carbono, alquenilo de 2 a 6 átomos de carbono, alquinilo de 2 a 6 átomos de carbono, alcoxi de 1 a 6 átomos de carbono, alquiltio de 1 a 6 átomos de carbono, O R2 ½ ½halo, hidroxi, ciano, -- C --N -- R3 en la cual R2 y R3 son cada uno independientemente hidrógeno o alquilo de 1 a 6 átomos de carbono, -COO-alquilo de 1 a 6 carbonos, CF3 , (C1 -C6 ) alquilfenilo, fenilo o fenilo substituido por uno o más de alquilo de 1 a 6 átomos de carbono, -COO-alquilo de 1 a 6 átomos de carbono, O R2 ½ ½ --C -- N -- R3 en la cual R2 y R3 son como se definen anteriormente, halo, hidroxi, -O-alquilo de 1 a 6 átomos de carbono, -S-alquilo de 1 a 6 átomos de carbono o alquenilo de 2 a 6 átomos de carbono; p es 0, 1 ó 2; A es V-(Rc )n -; Rc es un grupo alquilo de cadena recta o ramificada; n es O o un número entero desde 1 hasta 6 Ra y Rb cuando se toman conjuntamente forman un grupo oxo (=O), o Ra y Rb son cada uno independientemente hidrógeno u OH; V es O, -S-, -SO- -SO2 - CONH o NHCO cuando n es un número entero de 1 a 6 o V es alquenilo de 2 a 6 átomos de carbono o un enlace cuando n es O o un número entero de 1 a 6; D es -(CH2 )m o un enlace que une el anillo a Y; m es un número entero de 1 a 6;½y es -O-, -S-, -SO-, -SO2 , -N-R4 o un enlace; R4 es como se define anteriormente para R7 ; Z es:En aspectos adicionales, la presente invención proporciona composiciones farmacéuticas que comprenden una cantidad terapéuticamente efectiva de un compuesto de la fórmula I y un portador farmacéuticamente aceptable.
CO98054714A 1997-09-23 1998-09-22 COMPUESTOS INHIBIDORES SELECTIVOS DE LAS ENZIMAS DE cPLA2 Y COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN CO4970751A1 (es)

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