CO4480030A1 - QUANTITATIVE SYNTHESIS OF ACID 3- (L-PIROGLUTAMIL) -L- TIAZOLIDIN-4-CARBOXILICO AND ITS DERIVATIVES - Google Patents

QUANTITATIVE SYNTHESIS OF ACID 3- (L-PIROGLUTAMIL) -L- TIAZOLIDIN-4-CARBOXILICO AND ITS DERIVATIVES

Info

Publication number
CO4480030A1
CO4480030A1 CO95044814A CO95044814A CO4480030A1 CO 4480030 A1 CO4480030 A1 CO 4480030A1 CO 95044814 A CO95044814 A CO 95044814A CO 95044814 A CO95044814 A CO 95044814A CO 4480030 A1 CO4480030 A1 CO 4480030A1
Authority
CO
Colombia
Prior art keywords
carbon
atoms
compound
formula
piroglutamil
Prior art date
Application number
CO95044814A
Other languages
Spanish (es)
Inventor
Stefano Poli
Magni Ambrogio
Gianettore Bocchiola
Original Assignee
Poli Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poli Ind Chimica Spa filed Critical Poli Ind Chimica Spa
Publication of CO4480030A1 publication Critical patent/CO4480030A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN COMPUESTO DE LA FORMULA (III) FIGURA 1 EN LA CUAL R1 REPRESENTA H, ALQUILO CON 1 A 6 ATO- MOS DE CARBONO, CICLOALQUILO CON DE 3 A 7 ATOMOS DE CARBONO, CICLOALQUILALQUILO CON DE 4 A 10 ATO- MOS DE CARBONO, ARILO Y ARILO SUBSTITUIDO, ALCOXI- CARBONILO CON DE 2 A 10 ATOMOS DE CARBONO, ARIL- CARBONILO Y ARALALQUILCARBONILO, ARALALCOXICARBO- XILO CON 8 A 13 ATOMOS DE CARBONO, ARALCOXICARBO- NILO SUBSTITUIDO, EL PROCESO ESTA CARACTERIZADO PORQUE COMPRENDE: a) LA REACCION DE UN COMPUESTO DE LA FORMULA (I): FIGURA 2 EN LA CUAL R1 ES COMO SE DEFINIO ANTES y X REPRE- SENTA OH, Cl o OR2 DONDE R2 ES UN GRUPO ACTIVANTE, CON UN COMPUESTO DE LA FORMULA (II) FIGURA 3 EN LA CUAL R3 REPRESENTA H, TRIALQUILSILILO CON DE 3 A 9 ATOMOS DE CARBONO, EN SOLVENTES APROTICOS APOLARES; b) LA HIDROLISIS BASICA DEL ESTER ETILICO OBTENIDO EN LA ETAPA a) EN CONDICIONES DE TRANSFERENCIA DE FASE.PROCEDURE FOR THE PREPARATION OF A COMPOUND OF FORMULA (III) FIGURE 1 IN WHICH R1 REPRESENTS H, RENT WITH 1 TO 6 ATOMS OF CARBON, CYCLOALKYL WITH 3 TO 7 ATOMS OF CARBON, CYCLOALKYLALKYL WITH 4 TO 10 ATO - MOS OF CARBON, ARYL AND SUBSTITUTED ARYL, ALCOXY-CARBONYL WITH 2 TO 10 ATOMS OF CARBON, ARYL-CARBONYL, ARALALCOXICARBO- XYL WITH 8 TO 13 ATOMS OF CARBON, ARALCOXYCARBON, SUZAR : a) THE REACTION OF A COMPOUND OF FORMULA (I): FIGURE 2 IN WHICH R1 IS AS DEFINED BEFORE AND X REPRESENTS OH, Cl or OR2 WHERE R2 IS AN ACTIVATING GROUP, WITH A COMPOUND OF THE FORMULA ( II) FIGURE 3 IN WHICH R3 REPRESENTS H, TRIALCHYLSILYL WITH 3 TO 9 ATOMS OF CARBON, IN APOLAR APROTIC SOLVENTS; b) THE BASIC HYDROLYSIS OF THE ETHYL ESTER OBTAINED IN STAGE a) IN PHASE TRANSFER CONDITIONS.

CO95044814A 1994-09-27 1995-09-27 QUANTITATIVE SYNTHESIS OF ACID 3- (L-PIROGLUTAMIL) -L- TIAZOLIDIN-4-CARBOXILICO AND ITS DERIVATIVES CO4480030A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941955A IT1270017B (en) 1994-09-27 1994-09-27 "QUANTITATIVE SYNTHESIS OF 3- (L-PIROGLUTAMIL) -L-THIAZOLIDIN-4- CARBOXYLIC ACID AND ITS DERIVATIVES"

Publications (1)

Publication Number Publication Date
CO4480030A1 true CO4480030A1 (en) 1997-07-09

Family

ID=11369599

Family Applications (1)

Application Number Title Priority Date Filing Date
CO95044814A CO4480030A1 (en) 1994-09-27 1995-09-27 QUANTITATIVE SYNTHESIS OF ACID 3- (L-PIROGLUTAMIL) -L- TIAZOLIDIN-4-CARBOXILICO AND ITS DERIVATIVES

Country Status (10)

Country Link
CN (1) CN1143863C (en)
BG (1) BG63895B1 (en)
BR (1) BR9509087A (en)
CO (1) CO4480030A1 (en)
CZ (1) CZ91597A3 (en)
IT (1) IT1270017B (en)
PL (1) PL181824B1 (en)
RO (1) RO115957B1 (en)
SK (1) SK40097A3 (en)
WO (1) WO1996010036A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108088936B (en) * 2017-12-08 2020-05-22 常州寅盛药业有限公司 Impurity obtained in preparation of pidotimod ethyl ester and quality detection method thereof
CN108715598A (en) * 2018-06-13 2018-10-30 峨眉山宏昇药业股份有限公司 A kind of preparation method of Pidotimod
CN117088939A (en) * 2022-05-11 2023-11-21 江苏吴中医药集团有限公司 Preparation method of pidotimod

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1202426B (en) * 1987-01-26 1989-02-09 Poli Ind Chimica Spa THIAZOLIDIN-4-CARBOXYLIC ACID DERIVATIVE, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT
IT1239029B (en) * 1989-10-12 1993-09-20 Poli Ind Chimica Spa PROCESS FOR THE PREPARATION OF 3- (L-PYROGLUTAMYL) -L- THIAZOLIDIN-4-CARBOXYLIC ACID AND ITS DERIVATIVES.

Also Published As

Publication number Publication date
SK40097A3 (en) 1997-09-10
BG101310A (en) 1997-12-30
PL319380A1 (en) 1997-08-04
WO1996010036A1 (en) 1996-04-04
RO115957B1 (en) 2000-08-30
BR9509087A (en) 1998-07-21
CZ91597A3 (en) 1997-09-17
ITMI941955A1 (en) 1996-03-27
CN1143863C (en) 2004-03-31
CN1158620A (en) 1997-09-03
ITMI941955A0 (en) 1994-09-27
PL181824B1 (en) 2001-09-28
BG63895B1 (en) 2003-05-30
IT1270017B (en) 1997-04-16

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