CO2024004796A2 - Composiciones que actúan sobre bcma y métodos de uso de estas - Google Patents

Composiciones que actúan sobre bcma y métodos de uso de estas

Info

Publication number
CO2024004796A2
CO2024004796A2 CONC2024/0004796A CO2024004796A CO2024004796A2 CO 2024004796 A2 CO2024004796 A2 CO 2024004796A2 CO 2024004796 A CO2024004796 A CO 2024004796A CO 2024004796 A2 CO2024004796 A2 CO 2024004796A2
Authority
CO
Colombia
Prior art keywords
bcma
binding agents
car
compositions
act
Prior art date
Application number
CONC2024/0004796A
Other languages
English (en)
Inventor
Shawn Jennings
Michael Curley
Ertan Eryilmaz
Leeann Talarico
Taylor Hickman
Christina Sheau Fen Wong
Kathryn Fraser
Haiqing Wang
Alessandra Piersigilli
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of CO2024004796A2 publication Critical patent/CO2024004796A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a agentes de unión a BCMA (por ejemplo, anticuerpos) y construcciones de receptores de antígenos quiméricos (CAR) que comprenden una molécula de unión al antígeno de BCMA. Los agentes de unión de BCMA se unen específicamente a BCMA. Los presentes CAR de BCMA comprenden, además, una región bisagra (por ejemplo, bisagra de CD28), un dominio transmembrana y uno o más dominios de señalización de células NK intracelulares. Las células NK que expresan un CAR de BCMA tienen mayor eficacia en la destrucción de células cancerosas. En la presente también se incluyen los usos terapéuticos de los agentes de unión de BCMA y los CAR de BCMA.
CONC2024/0004796A 2021-10-20 2024-04-17 Composiciones que actúan sobre bcma y métodos de uso de estas CO2024004796A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163257822P 2021-10-20 2021-10-20
US202163257846P 2021-10-20 2021-10-20
PCT/JP2022/040573 WO2023068382A2 (en) 2021-10-20 2022-10-19 Compositions targeting bcma and methods of use thereof

Publications (1)

Publication Number Publication Date
CO2024004796A2 true CO2024004796A2 (es) 2024-05-20

Family

ID=84361139

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2024/0004796A CO2024004796A2 (es) 2021-10-20 2024-04-17 Composiciones que actúan sobre bcma y métodos de uso de estas

Country Status (7)

Country Link
AR (1) AR127408A1 (es)
AU (1) AU2022372894A1 (es)
CA (1) CA3236038A1 (es)
CO (1) CO2024004796A2 (es)
IL (1) IL311837A (es)
TW (1) TW202330612A (es)
WO (1) WO2023068382A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023232912A1 (en) * 2022-05-31 2023-12-07 Oncopeptides Innovation 1 Ab Novel polypeptides

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Also Published As

Publication number Publication date
TW202330612A (zh) 2023-08-01
CA3236038A1 (en) 2023-04-27
AR127408A1 (es) 2024-01-17
WO2023068382A2 (en) 2023-04-27
AU2022372894A1 (en) 2024-04-18
IL311837A (en) 2024-05-01
WO2023068382A3 (en) 2023-07-06

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