CO2024001256A2 - Compuesto inductor de la degradación de plk1 novedoso - Google Patents
Compuesto inductor de la degradación de plk1 novedosoInfo
- Publication number
- CO2024001256A2 CO2024001256A2 CONC2024/0001256A CO2024001256A CO2024001256A2 CO 2024001256 A2 CO2024001256 A2 CO 2024001256A2 CO 2024001256 A CO2024001256 A CO 2024001256A CO 2024001256 A2 CO2024001256 A2 CO 2024001256A2
- Authority
- CO
- Colombia
- Prior art keywords
- plk1
- degradation
- novel
- inducing compound
- present disclosure
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000015556 catabolic process Effects 0.000 title abstract 3
- 238000006731 degradation reaction Methods 0.000 title abstract 3
- 230000001939 inductive effect Effects 0.000 title abstract 2
- 101150073897 plk1 gene Proteins 0.000 title 1
- 102100031463 Serine/threonine-protein kinase PLK1 Human genes 0.000 abstract 3
- 108010056274 polo-like kinase 1 Proteins 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente divulgación se refiere a un compuesto inductor de la degradación de PLK1 novedoso, a un método para preparar el mismo y al uso del mismo. Los compuestos de la presente divulgación exhiben un efecto de inducción de la degradación de PLK1. Por lo tanto, los compuestos de la presente divulgación pueden utilizarse eficazmente para prevenir o tratar enfermedades relacionadas con PLK1.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20210105358 | 2021-08-10 | ||
| KR20210106488 | 2021-08-12 | ||
| KR20210117389 | 2021-09-03 | ||
| KR20210126757 | 2021-09-24 | ||
| KR20220008456 | 2022-01-20 | ||
| KR20220020996 | 2022-02-17 | ||
| KR20220054880 | 2022-05-03 | ||
| KR20220075838 | 2022-06-21 | ||
| PCT/KR2022/011961 WO2023018236A1 (en) | 2021-08-10 | 2022-08-10 | Novel plk1 degradation inducing compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2024001256A2 true CO2024001256A2 (es) | 2024-03-18 |
Family
ID=85200656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2024/0001256A CO2024001256A2 (es) | 2021-08-10 | 2024-02-06 | Compuesto inductor de la degradación de plk1 novedoso |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11939334B2 (es) |
| EP (2) | EP4157850A1 (es) |
| JP (2) | JP2023540729A (es) |
| KR (5) | KR102604801B1 (es) |
| CN (1) | CN116322700A (es) |
| AU (1) | AU2022327025A1 (es) |
| CA (1) | CA3228601A1 (es) |
| CO (1) | CO2024001256A2 (es) |
| IL (1) | IL310678A (es) |
| PE (1) | PE20240894A1 (es) |
| WO (5) | WO2023018237A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230158158A1 (en) * | 2020-03-27 | 2023-05-25 | Uppthera | Pyrazolo quinazoline derivative compounds inducing selective degradation of plk1 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5313875B2 (ja) * | 2006-04-12 | 2013-10-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | 増殖性疾患の処置のためのタンパク質キナーゼｐｌｋ１の阻害剤として有用な４，５−ジヒドロ−［１，２，４］トリアゾロ［４，３−ｆ］プテリジン |
| JP2011527667A (ja) * | 2008-06-18 | 2011-11-04 | 武田薬品工業株式会社 | ハロ置換ピリミドジアゼピン |
| US9694084B2 (en) * | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| BR112018008918A8 (pt) | 2015-11-02 | 2019-02-26 | Univ Yale | compostos de quimera proteólise dirigida e métodos para preparação e uso dos mesmos |
| CN106543185B (zh) | 2016-11-10 | 2017-12-15 | 吉林大学 | 一种靶向泛素化降解plk1和brd4蛋白的化合物及其应用 |
| CN106977584B (zh) * | 2017-04-19 | 2019-12-06 | 吉林大学 | 靶向泛素化降解plk1和brd4蛋白的化合物及其应用 |
| WO2020023851A1 (en) * | 2018-07-26 | 2020-01-30 | Yale University | Bifunctional substitued pyrimidines as modulators of fak proteolyse |
| CN109879877B (zh) * | 2019-03-04 | 2021-08-10 | 吉林大学 | 一种可降解plk1和brd4蛋白的化合物及其应用 |
| AU2020356484A1 (en) * | 2019-09-27 | 2022-03-17 | Dana-Farber Cancer Institute, Inc. | ERK5 degraders as therapeutics in cancer and inflammatory diseases |
-
2022
- 2022-08-10 KR KR1020227036557A patent/KR102604801B1/ko active IP Right Grant
- 2022-08-10 WO PCT/KR2022/011962 patent/WO2023018237A1/en active Application Filing
- 2022-08-10 EP EP22808931.4A patent/EP4157850A1/en active Pending
- 2022-08-10 KR KR1020227046443A patent/KR102662205B1/ko active IP Right Grant
- 2022-08-10 WO PCT/IB2022/057475 patent/WO2023017446A1/en unknown
- 2022-08-10 EP EP22808930.6A patent/EP4157849A1/en active Pending
- 2022-08-10 US US18/019,034 patent/US11939334B2/en active Active
- 2022-08-10 KR KR1020227042318A patent/KR102604803B1/ko active IP Right Grant
- 2022-08-10 JP JP2023514160A patent/JP2023540729A/ja active Pending
- 2022-08-10 IL IL310678A patent/IL310678A/en unknown
- 2022-08-10 CN CN202280006505.1A patent/CN116322700A/zh active Pending
- 2022-08-10 PE PE2024000208A patent/PE20240894A1/es unknown
- 2022-08-10 KR KR1020247013823A patent/KR20240060721A/ko active Application Filing
- 2022-08-10 WO PCT/KR2022/011963 patent/WO2023018238A1/en unknown
- 2022-08-10 JP JP2023514149A patent/JP2023540728A/ja active Pending
- 2022-08-10 US US18/019,047 patent/US11912710B2/en active Active
- 2022-08-10 WO PCT/IB2022/057471 patent/WO2023017442A1/en unknown
- 2022-08-10 AU AU2022327025A patent/AU2022327025A1/en active Pending
- 2022-08-10 CA CA3228601A patent/CA3228601A1/en active Pending
- 2022-08-10 WO PCT/KR2022/011961 patent/WO2023018236A1/en active Application Filing
- 2022-08-10 KR KR1020227036596A patent/KR102604802B1/ko active IP Right Grant
-
2024
- 2024-02-06 CO CONC2024/0001256A patent/CO2024001256A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20230219966A1 (en) | 2023-07-13 |
| WO2023018238A1 (en) | 2023-02-16 |
| US11912710B2 (en) | 2024-02-27 |
| KR102662205B1 (ko) | 2024-04-30 |
| KR20230024267A (ko) | 2023-02-20 |
| CN116322700A (zh) | 2023-06-23 |
| WO2023017442A1 (en) | 2023-02-16 |
| KR20230024302A (ko) | 2023-02-20 |
| US11939334B2 (en) | 2024-03-26 |
| JP2023540729A (ja) | 2023-09-26 |
| KR20230024250A (ko) | 2023-02-20 |
| KR20240060721A (ko) | 2024-05-08 |
| WO2023018236A1 (en) | 2023-02-16 |
| AU2022327025A1 (en) | 2024-03-21 |
| CA3228601A1 (en) | 2023-02-16 |
| WO2023017446A1 (en) | 2023-02-16 |
| KR102604803B1 (ko) | 2023-11-22 |
| US20230242541A1 (en) | 2023-08-03 |
| KR102604801B1 (ko) | 2023-11-22 |
| PE20240894A1 (es) | 2024-04-24 |
| EP4157850A1 (en) | 2023-04-05 |
| KR20230024251A (ko) | 2023-02-20 |
| JP2023540728A (ja) | 2023-09-26 |
| KR102604802B1 (ko) | 2023-11-22 |
| EP4157849A1 (en) | 2023-04-05 |
| IL310678A (en) | 2024-04-01 |
| WO2023018237A1 (en) | 2023-02-16 |
| CN116261458A (zh) | 2023-06-13 |
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