CO2023017151A2 - Inhibidores de ripk1 de nicotinamida - Google Patents
Inhibidores de ripk1 de nicotinamidaInfo
- Publication number
- CO2023017151A2 CO2023017151A2 CONC2023/0017151A CO2023017151A CO2023017151A2 CO 2023017151 A2 CO2023017151 A2 CO 2023017151A2 CO 2023017151 A CO2023017151 A CO 2023017151A CO 2023017151 A2 CO2023017151 A2 CO 2023017151A2
- Authority
- CO
- Colombia
- Prior art keywords
- nicotinamide
- ripk1
- inhibitors
- ripk1 inhibitors
- compounds
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title 2
- 229960003966 nicotinamide Drugs 0.000 title 1
- 235000005152 nicotinamide Nutrition 0.000 title 1
- 239000011570 nicotinamide Substances 0.000 title 1
- 101001109145 Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Proteins 0.000 abstract 1
- 102100022501 Receptor-interacting serine/threonine-protein kinase 1 Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
En la presente descripción se proporcionan compuestos de la Fórmula (I) y sales farmacéuticamente aceptables de estos, útiles como inhibidores de RIPK1, y composiciones farmacéuticas que los comprenden. Además se proporcionan métodos de uso y preparación. (I
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163231590P | 2021-08-10 | 2021-08-10 | |
PCT/US2022/039689 WO2023018643A1 (en) | 2021-08-10 | 2022-08-08 | Nicotinamide ripk1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2023017151A2 true CO2023017151A2 (es) | 2023-12-29 |
Family
ID=83439074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2023/0017151A CO2023017151A2 (es) | 2021-08-10 | 2023-12-11 | Inhibidores de ripk1 de nicotinamida |
Country Status (13)
Country | Link |
---|---|
US (1) | US11767310B2 (es) |
EP (1) | EP4301744A1 (es) |
JP (2) | JP7406672B2 (es) |
KR (1) | KR20230163568A (es) |
CN (1) | CN117460722A (es) |
AR (1) | AR126733A1 (es) |
AU (1) | AU2022328136A1 (es) |
BR (1) | BR112023025850A2 (es) |
CA (1) | CA3219155A1 (es) |
CO (1) | CO2023017151A2 (es) |
IL (1) | IL308349A (es) |
TW (1) | TW202321211A (es) |
WO (1) | WO2023018643A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4301744A1 (en) | 2021-08-10 | 2024-01-10 | AbbVie Inc. | Nicotinamide ripk1 inhibitors |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
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KR970705560A (ko) | 1995-08-02 | 1997-10-09 | 호아껭 우리아치 토렐로 | 항진균 활성을 갖는 신규한 카르복사미드(new carboxamides with antifungal activity) |
US6723727B1 (en) | 1996-12-20 | 2004-04-20 | Hoechst Aktiengesellschaft | Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them |
US6218387B1 (en) | 1996-12-20 | 2001-04-17 | Hoechst Aktiengesellschaft | Vitronectin receptor anatagonists, their preparation and their use |
US7666862B2 (en) | 2003-08-15 | 2010-02-23 | Merck & Co., Inc. | Mitotic Kinesin Inhibitors |
ES2319429T3 (es) | 2003-08-15 | 2009-05-07 | MERCK & CO., INC. | Inhibidores de cinesina mitotica. |
US7112316B1 (en) | 2005-08-08 | 2006-09-26 | Uop Llc | Process for preparing molecular sieves via continuous addition of nutrients |
US20100121048A1 (en) | 2006-02-16 | 2010-05-13 | Takanobu Kuroita | Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension |
ES2360929T3 (es) | 2007-09-20 | 2011-06-10 | Amgen Inc. | Derivados del ácido 1-(4-(4-bencilbenzamido)-bencil)azetidin-3-carboxílico y compuestos relacionados como moduladores del receptor s1p para el tratamiento de trastornos inmunitarios. |
AU2009225869B2 (en) | 2008-03-18 | 2014-01-23 | Merck Sharp & Dohme Llc | Substituted 4-hydroxypyrimidine-5-carboxamides |
MX2011010905A (es) | 2009-04-15 | 2011-11-01 | Abbott Lab | Compuestos antivirales. |
WO2011113707A1 (en) | 2010-03-17 | 2011-09-22 | Exxonmobil Chemical Patents Inc. | Plasticiser blends and compositions and articles made therefrom |
MX367623B (es) | 2010-10-20 | 2019-08-29 | Gruenenthal Gmbh | 6-amino-nicotinamidas sustituidas como moduladores de kcnq2/3. |
WO2013049255A1 (en) | 2011-09-26 | 2013-04-04 | Vanderbilt University | Substitued 5-(prop-1-yn-1-yl)picolinamide analogs as allosteric modulators of mglur5 receptors |
TWI637951B (zh) | 2013-02-15 | 2018-10-11 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類 |
PT3087051T (pt) | 2013-12-24 | 2020-10-21 | Oncotartis Inc | Compostos de nicotinamida e benzamida e métodos para utilizar os mesmos |
KR101555033B1 (ko) | 2014-07-28 | 2015-09-23 | 충남대학교산학협력단 | 신규한 메타논 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 망막 질환의 예방 또는 치료용 약학적 조성물 |
KR101551313B1 (ko) | 2014-07-28 | 2015-09-09 | 충남대학교산학협력단 | 신규한 인덴 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 망막 질환의 예방 또는 치료용 약학적 조성물 |
US20170266199A1 (en) | 2014-08-21 | 2017-09-21 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as rip1 kinase inhibitors as medicaments |
JP6772141B2 (ja) | 2014-12-24 | 2020-10-21 | ナショナル・インスティチュート・オブ・バイオロジカル・サイエンシズ,ベイジン | ネクローシス阻害薬 |
UY36680A (es) | 2015-05-19 | 2016-12-30 | Glaxosmithkline Ip Dev Ltd | Amidas heterocíclicas como inhibidores de quinasa |
TWI763630B (zh) | 2015-07-02 | 2022-05-11 | 瑞士商赫孚孟拉羅股份公司 | 雙環內醯胺及其使用方法 |
CN108431004B (zh) | 2015-10-23 | 2021-02-12 | 武田药品工业株式会社 | 杂环化合物 |
CN108602809B (zh) | 2015-12-04 | 2022-09-30 | 戴纳立制药公司 | 异噁唑烷衍生的受体相互作用蛋白激酶1(ripk 1)的抑制剂 |
US10961258B2 (en) | 2015-12-21 | 2021-03-30 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
CR20180413A (es) | 2016-02-05 | 2018-12-04 | Denali Therapeutics Inc | Inhibidores de la proteína quinasa 1 que interactua con el receptor |
US20200040025A1 (en) | 2016-09-26 | 2020-02-06 | Tufts University | Uridine nucleoside derivatives, compositions and methods of use |
PT3580220T (pt) | 2017-02-13 | 2022-01-03 | Bristol Myers Squibb Co | Aminotriazolopiridinas como inibidores de quinase |
DE102017211104B3 (de) | 2017-06-29 | 2018-10-18 | Bundesdruckerei Gmbh | Verfahren und Vorrichtung zum Verifizieren eines elektrolumineszierenden Sicherheitsmerkmals in einem Wert- oder Sicherheitsdokument unter Ausnutzung von zusätzlicher Lichtstrahlung |
HUE063896T2 (hu) | 2018-05-03 | 2024-02-28 | Rigel Pharmaceuticals Inc | RIP1 inhibitorvegyületek, valamint ezek elõállítása és alkalmazása |
CN110194772B (zh) | 2018-07-02 | 2022-04-05 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白激酶活性的炔基(杂)芳环类化合物 |
US20210284647A1 (en) | 2018-07-10 | 2021-09-16 | Voronoibio Inc. | N-(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylphenyl)-5-phenyl-4,5-dihydro-1h-pyrazole-1-carboxamide derivative, and pharmaceutical composition containing same as active ingredient for treating kinase-related diseases |
KR20200089219A (ko) | 2019-01-15 | 2020-07-24 | 보로노이 주식회사 | 아릴 또는 헤테로아릴 유도체, 및 이를 유효성분으로 포함하는 키나아제 관련 질환 치료용 약학적 조성물 |
EP4301744A1 (en) | 2021-08-10 | 2024-01-10 | AbbVie Inc. | Nicotinamide ripk1 inhibitors |
-
2022
- 2022-08-08 EP EP22777032.8A patent/EP4301744A1/en active Pending
- 2022-08-08 TW TW111129732A patent/TW202321211A/zh unknown
- 2022-08-08 US US17/882,709 patent/US11767310B2/en active Active
- 2022-08-08 AU AU2022328136A patent/AU2022328136A1/en active Pending
- 2022-08-08 WO PCT/US2022/039689 patent/WO2023018643A1/en active Application Filing
- 2022-08-08 IL IL308349A patent/IL308349A/en unknown
- 2022-08-08 CA CA3219155A patent/CA3219155A1/en active Pending
- 2022-08-08 KR KR1020237038931A patent/KR20230163568A/ko not_active Application Discontinuation
- 2022-08-08 JP JP2023516136A patent/JP7406672B2/ja active Active
- 2022-08-08 AR ARP220102125A patent/AR126733A1/es unknown
- 2022-08-08 BR BR112023025850A patent/BR112023025850A2/pt unknown
- 2022-08-08 CN CN202280041334.6A patent/CN117460722A/zh active Pending
-
2023
- 2023-12-11 CO CONC2023/0017151A patent/CO2023017151A2/es unknown
- 2023-12-14 JP JP2023210859A patent/JP2024037892A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2022328136A1 (en) | 2023-11-30 |
JP2023549007A (ja) | 2023-11-22 |
WO2023018643A1 (en) | 2023-02-16 |
JP7406672B2 (ja) | 2023-12-27 |
JP2024037892A (ja) | 2024-03-19 |
CN117460722A (zh) | 2024-01-26 |
US11767310B2 (en) | 2023-09-26 |
KR20230163568A (ko) | 2023-11-30 |
IL308349A (en) | 2024-01-01 |
AR126733A1 (es) | 2023-11-08 |
BR112023025850A2 (pt) | 2024-03-05 |
TW202321211A (zh) | 2023-06-01 |
EP4301744A1 (en) | 2024-01-10 |
US20230127127A1 (en) | 2023-04-27 |
CA3219155A1 (en) | 2023-02-16 |
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