CO2023009089A2 - Anticuerpos anti-n3pglu beta amiloide y usos de estos - Google Patents

Anticuerpos anti-n3pglu beta amiloide y usos de estos

Info

Publication number
CO2023009089A2
CO2023009089A2 CONC2023/0009089A CO2023009089A CO2023009089A2 CO 2023009089 A2 CO2023009089 A2 CO 2023009089A2 CO 2023009089 A CO2023009089 A CO 2023009089A CO 2023009089 A2 CO2023009089 A2 CO 2023009089A2
Authority
CO
Colombia
Prior art keywords
n3pglu
relates
antibodies
beta amyloid
amyloid antibodies
Prior art date
Application number
CONC2023/0009089A
Other languages
English (en)
Spanish (es)
Inventor
Adam S Fleisher
Mark Mintun
John Randall Ii Sims
Jondavid Sparks
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO2023009089A2 publication Critical patent/CO2023009089A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CONC2023/0009089A 2021-01-11 2023-07-07 Anticuerpos anti-n3pglu beta amiloide y usos de estos CO2023009089A2 (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202163135932P 2021-01-11 2021-01-11
US202163155029P 2021-03-01 2021-03-01
US202163160380P 2021-03-12 2021-03-12
US202163192262P 2021-05-24 2021-05-24
US202163227054P 2021-07-29 2021-07-29
US202163277298P 2021-11-09 2021-11-09
US202163284248P 2021-11-30 2021-11-30
US202263296694P 2022-01-05 2022-01-05
PCT/US2022/011894 WO2022150735A1 (en) 2021-01-11 2022-01-11 Anti-n3pglu amyloid beta antibodies and uses thereof

Publications (1)

Publication Number Publication Date
CO2023009089A2 true CO2023009089A2 (es) 2023-09-29

Family

ID=80123357

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0009089A CO2023009089A2 (es) 2021-01-11 2023-07-07 Anticuerpos anti-n3pglu beta amiloide y usos de estos

Country Status (15)

Country Link
US (1) US20240010713A1 (https=)
EP (1) EP4274611A1 (https=)
JP (2) JP7676556B2 (https=)
KR (2) KR20260047659A (https=)
AU (1) AU2022206461B2 (https=)
CA (1) CA3204444A1 (https=)
CL (1) CL2023001992A1 (https=)
CO (1) CO2023009089A2 (https=)
EC (1) ECSP23051813A (https=)
IL (1) IL304072A (https=)
MX (1) MX2023008196A (https=)
PE (1) PE20231748A1 (https=)
TW (1) TWI843040B (https=)
WO (1) WO2022150735A1 (https=)
ZA (1) ZA202306180B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022307687A1 (en) * 2021-07-09 2024-01-04 Eisai R&D Management Co., Ltd. Biomarkers for alzheimer's disease treatment
WO2023039107A2 (en) 2021-09-09 2023-03-16 Alzpath, Inc. Phospho-tau antibodies and methods of use
CA3243602A1 (en) * 2022-02-03 2023-08-10 Eli Lilly And Company Regional Tau Imaging for the Diagnosis and Treatment of Alzheimer's Disease
KR20250107906A (ko) * 2022-11-17 2025-07-14 일라이 릴리 앤드 캄파니 항-N3pGlu 아밀로이드 베타 항체, 그의 용량 및 용도
KR20250173598A (ko) * 2023-03-16 2025-12-10 알즈패스, 인크. 신경퇴행성 질환의 진단 및 치료 방법
WO2025231343A1 (en) * 2024-05-03 2025-11-06 Therini Bio, Inc. Doses of antibodies which bind human fibrin yc or fibrinogen yc domain for neurodegenerative diseases
WO2025240435A1 (en) * 2024-05-14 2025-11-20 Othair Prothena Limited Methods of treating neurological disorders with anti-abeta antibodies

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1257584T1 (de) 2000-02-24 2003-05-28 Lilly Co Eli Humanisierte antikörper, die amyloid beta peptid demarkieren
PT1944040E (pt) 2001-08-17 2012-10-31 Univ Washington Método de avaliação para a doença de alzheimer
SI1720909T1 (sl) 2004-02-23 2012-01-31 Lilly Co Eli Anti-abeta protitelo
WO2010009987A2 (en) 2008-07-21 2010-01-28 Probiodrug Ag Diagnostic antibody assay
WO2011151076A2 (en) 2010-06-04 2011-12-08 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin MONOCLONAL ANTIBODIES TARGETING Αβ OLIGOMERS
PL3042917T3 (pl) 2010-08-12 2018-07-31 Eli Lilly And Company Przeciwciała przeciwko peptydowi beta amyloidu N3pGlu i ich zastosowanie
WO2012021475A2 (en) * 2010-08-12 2012-02-16 Eli Lilly And Company ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF
US9499610B2 (en) 2011-04-08 2016-11-22 H. Lundbeck A/S Antibodies specific to pyroglutamated Aβ
JOP20170004B1 (ar) 2016-01-15 2022-09-15 Lilly Co Eli الأجسام المضادة لببتيد بيتا النشوي مضاد N3pGlu واستخداماته
TWI798751B (zh) * 2016-07-01 2023-04-11 美商美國禮來大藥廠 抗-N3pGlu類澱粉β肽抗體及其用途
TWI789644B (zh) 2017-04-20 2023-01-11 美商美國禮來大藥廠 抗-N3pGlu類澱粉β肽抗體及其用途
CN107289872A (zh) 2017-06-28 2017-10-24 京东方科技集团股份有限公司 测高装置
KR102905634B1 (ko) 2019-05-31 2025-12-30 일라이 릴리 앤드 캄파니 인간 타우를 표적화하는 화합물 및 방법

Also Published As

Publication number Publication date
TWI843040B (zh) 2024-05-21
AU2022206461A1 (en) 2023-06-29
ZA202306180B (en) 2025-02-26
PE20231748A1 (es) 2023-11-06
TW202243690A (zh) 2022-11-16
IL304072A (en) 2023-08-01
MX2023008196A (es) 2023-07-18
KR20260047659A (ko) 2026-04-08
CA3204444A1 (en) 2022-07-14
WO2022150735A1 (en) 2022-07-14
KR20230130695A (ko) 2023-09-12
EP4274611A1 (en) 2023-11-15
KR102942744B1 (ko) 2026-03-23
JP7676556B2 (ja) 2025-05-14
CL2023001992A1 (es) 2024-02-02
US20240010713A1 (en) 2024-01-11
JP2025131566A (ja) 2025-09-09
JP2024503025A (ja) 2024-01-24
AU2022206461B2 (en) 2026-02-05
ECSP23051813A (es) 2023-08-31

Similar Documents

Publication Publication Date Title
CO2023009089A2 (es) Anticuerpos anti-n3pglu beta amiloide y usos de estos
AR132544A2 (es) ANTICUERPOS PEPTÍDICOS b AMILOIDE ANTI-N3pGlu Y USOS DE LOS MISMOS
Zhang et al. Electroacupuncture improves cognitive deficits and activates PPAR-γ in a rat model of Alzheimer's disease
Guo et al. Electroacupuncture Improves Memory and Protects Neurons by Regulation of the Autophagy Pathway in a Rat Model of Alzheimer—s Disease
MX2018012221A (es) Metodos para tratar hiperlipidemia con un inhibidor de proteina tipo angiopoyetina 8 y un inhibidor de proteina tipo angiopoyetina 3.
AR100772A1 (es) Métodos para aumentar la inhibición tónica y tratar el insomnio secundario
EA201892690A1 (ru) АНТИТЕЛА К БЕТА-АМИЛОИДНОМУ ПЕПТИДУ N3pGlu И ИХ ПРИМЕНЕНИЕ
RU2017112747A (ru) Фармацевтические композиции, содержащие декстрометорфановое соединение и хинидин для лечения возбуждения при деменции
BR112023016319A2 (pt) Anticorpos anti-beta amiloide e usos dos mesmos
IL286268A (en) Pridopidine for use in the treatment of mitochondrial associated diseases and disorders, including symptoms thereof
CL2020002465A1 (es) Método de tratamiento de enfermedad fibrótica
MX2019002827A (es) Acidos grasos omega 3 y colina como neuroprotectores en pacientes sin demencia.
EA201691656A2 (ru) Терапевтические способы с применением норибогаина и родственных соединений
EA202193190A1 (ru) Композиция, включающая придопидин и его аналог, для лечения болезни гентингтона и ее симптомов
EP4438048A4 (en) PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED TO T LYMPHOCYTES
EP4522772A4 (en) TREATMENT OF DISEASES AND DISORDERS WITH MIRACLES MODIFYING COMPOUNDS 4
BR112023021235A2 (pt) Formas cocristalinas de um inibidor da tirosina quinase de bruton
Shahsavand-Ananloo et al. Comparing effects of citalopram with fluoxetine on sleep quality in patients with major depressive disorder.
RU2019110264A (ru) Циклическое соединение
DOP2024000203A (es) Composición que comprende n-acetilcisteína, vitamina d y preferentemente glutatión, usos de la misma, y composiciones farmacéuticas y nutracéuticas de los mismos
EP4356916A4 (en) Pharmaceutical composition for alleviating or treating sequelae of cerebral infarction
Bano et al. Effectiveness of melatonin supplementation in preventing cognitive decline among older adults with sleep disorders: a narrative review
Sivolap Serotonin neurotrasmission and treatment options for depression
BR112018072164A2 (pt) composição farmacêutica, método para tratamento e/ou prevenção de uma doença de pele de um paciente e/ou para alívio dos sintomas da mesma, e, uso cosmético de uma composição
Poojary et al. Acupressure–a review with a current and future prospective in dentistry