CO2023007726A2 - Tratamiento para la deficiencia de enpp1 y la deficiencia de abcc6 - Google Patents
Tratamiento para la deficiencia de enpp1 y la deficiencia de abcc6Info
- Publication number
- CO2023007726A2 CO2023007726A2 CONC2023/0007726A CO2023007726A CO2023007726A2 CO 2023007726 A2 CO2023007726 A2 CO 2023007726A2 CO 2023007726 A CO2023007726 A CO 2023007726A CO 2023007726 A2 CO2023007726 A2 CO 2023007726A2
- Authority
- CO
- Colombia
- Prior art keywords
- deficiency
- enpp1
- treatment
- abcc6
- calcification
- Prior art date
Links
- 230000007812 deficiency Effects 0.000 title abstract 5
- 101000812677 Homo sapiens Nucleotide pyrophosphatase Proteins 0.000 abstract 3
- 102100039306 Nucleotide pyrophosphatase Human genes 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000004434 Calcinosis Diseases 0.000 abstract 2
- 208000033173 Generalized arterial calcification of infancy Diseases 0.000 abstract 2
- 208000004900 arterial calcification of infancy Diseases 0.000 abstract 2
- 230000002308 calcification Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 102100028187 ATP-binding cassette sub-family C member 6 Human genes 0.000 abstract 1
- 101000986621 Homo sapiens ATP-binding cassette sub-family C member 6 Proteins 0.000 abstract 1
- 201000003672 autosomal recessive hypophosphatemic rickets Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 210000004872 soft tissue Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04001—Phosphodiesterase I (3.1.4.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente descripción proporciona, entre otras cosas, dosis específicas de un agente de ENPP1 para el tratamiento in vivo de una deficiencia de ENPP1, tal como para el tratamiento de la calcificación arterial generalizada de la infancia (GACI), el raquitismo hipofosfatémico autosómico recesivo 2 (ARHR2), y otras enfermedades que resultan de la calcificación patológica, la deficiencia de ENPP1, la deficiencia de ABCC6 tales como enfermedades o trastornos que involucran la calcificación ectópica de tejido blando en un sujeto.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063116106P | 2020-11-19 | 2020-11-19 | |
| US202063116086P | 2020-11-19 | 2020-11-19 | |
| US202063116093P | 2020-11-19 | 2020-11-19 | |
| US202163219229P | 2021-07-07 | 2021-07-07 | |
| US202163237351P | 2021-08-26 | 2021-08-26 | |
| PCT/US2021/060207 WO2022109344A1 (en) | 2020-11-19 | 2021-11-19 | Treatment of enpp1 deficiency and abcc6 deficiency |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2023007726A2 true CO2023007726A2 (es) | 2023-07-21 |
Family
ID=81709698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2023/0007726A CO2023007726A2 (es) | 2020-11-19 | 2023-06-14 | Tratamiento para la deficiencia de enpp1 y la deficiencia de abcc6 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP4247406A1 (es) |
| JP (1) | JP2024500285A (es) |
| KR (1) | KR20230123932A (es) |
| AU (1) | AU2021383830A1 (es) |
| CA (1) | CA3198957A1 (es) |
| CO (1) | CO2023007726A2 (es) |
| IL (1) | IL302954A (es) |
| MX (1) | MX2023005836A (es) |
| TW (1) | TW202235100A (es) |
| WO (1) | WO2022109344A1 (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2899895T3 (es) * | 2014-12-19 | 2022-03-15 | Inozyme Pharma Inc | Procedimientos de tratamiento de calcificación tisular |
| KR20210142599A (ko) * | 2019-01-18 | 2021-11-25 | 이노자임 파마, 인코포레이티드 | Enpp1 또는 enpp3 결핍을 수반하는 질환의 치료 |
-
2021
- 2021-11-19 EP EP21895719.9A patent/EP4247406A1/en active Pending
- 2021-11-19 JP JP2023530251A patent/JP2024500285A/ja active Pending
- 2021-11-19 KR KR1020237017319A patent/KR20230123932A/ko unknown
- 2021-11-19 TW TW110143242A patent/TW202235100A/zh unknown
- 2021-11-19 CA CA3198957A patent/CA3198957A1/en active Pending
- 2021-11-19 WO PCT/US2021/060207 patent/WO2022109344A1/en active Application Filing
- 2021-11-19 MX MX2023005836A patent/MX2023005836A/es unknown
- 2021-11-19 AU AU2021383830A patent/AU2021383830A1/en active Pending
- 2021-11-19 IL IL302954A patent/IL302954A/en unknown
-
2023
- 2023-06-14 CO CONC2023/0007726A patent/CO2023007726A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL302954A (en) | 2023-07-01 |
| EP4247406A1 (en) | 2023-09-27 |
| TW202235100A (zh) | 2022-09-16 |
| MX2023005836A (es) | 2023-08-17 |
| AU2021383830A1 (en) | 2023-06-22 |
| WO2022109344A1 (en) | 2022-05-27 |
| KR20230123932A (ko) | 2023-08-24 |
| JP2024500285A (ja) | 2024-01-09 |
| CA3198957A1 (en) | 2022-05-27 |
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