CO2023004385A2 - Dispositivo de retención celular - Google Patents

Dispositivo de retención celular

Info

Publication number
CO2023004385A2
CO2023004385A2 CONC2023/0004385A CO2023004385A CO2023004385A2 CO 2023004385 A2 CO2023004385 A2 CO 2023004385A2 CO 2023004385 A CO2023004385 A CO 2023004385A CO 2023004385 A2 CO2023004385 A2 CO 2023004385A2
Authority
CO
Colombia
Prior art keywords
support
filter medium
ribs
peaks
retention device
Prior art date
Application number
CONC2023/0004385A
Other languages
English (en)
Inventor
Andrew Banchieri
Flora Liu
Marc Miller Graham
Original Assignee
Sunflower Therapeutics Pbc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunflower Therapeutics Pbc filed Critical Sunflower Therapeutics Pbc
Publication of CO2023004385A2 publication Critical patent/CO2023004385A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/06—Tubular membrane modules
    • B01D63/062—Tubular membrane modules with membranes on a surface of a support tube
    • B01D63/065—Tubular membrane modules with membranes on a surface of a support tube on the outer surface thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/06—Tubular membrane modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10—Supported membranes; Membrane supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10—Supported membranes; Membrane supports
    • B01D69/107—Organic support material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10—Supported membranes; Membrane supports
    • B01D69/108—Inorganic support material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/08—Polysaccharides
    • B01D71/12—Cellulose derivatives
    • B01D71/14—Esters of organic acids
    • B01D71/16—Cellulose acetate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/66—Polymers having sulfur in the main chain, with or without nitrogen, oxygen or carbon only
    • B01D71/68—Polysulfones; Polyethersulfones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/06—Tubular
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/06—External membrane module supporting or fixing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/08—Flow guidance means within the module or the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/12—Specific discharge elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B01D2325/0283—Pore size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/20—Specific permeability or cut-off range
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/08—Polysaccharides
    • B01D71/10—Cellulose; Modified cellulose
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/30—Polyalkenyl halides
    • B01D71/32—Polyalkenyl halides containing fluorine atoms
    • B01D71/34—Polyvinylidene fluoride
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/50—Polycarbonates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Un dispositivo de retención celular incluye un soporte estructurado con una pluralidad de nervaduras distribuidas circunferencialmente para retener la superficie de filtración activa de un medio de filtro de membrana poroso y flexible. El medio de filtro rodea el soporte en contacto con los picos de las nervaduras, formando de este modo huecos axiales entre los picos de las nervaduras. Esta disposición imparte suficiente soporte estructural sobre pequeñas regiones del medio de filtro para facilitar su uso en una configuración circular (u otra redondeada) al tiempo que proporciona suficiente volumen de canal para soportar un alto rendimiento de dispersión de fluido de las células.
CONC2023/0004385A 2020-09-08 2023-04-05 Dispositivo de retención celular CO2023004385A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063075443P 2020-09-08 2020-09-08
PCT/US2021/049251 WO2022055859A1 (en) 2020-09-08 2021-09-07 Cell retention device

Publications (1)

Publication Number Publication Date
CO2023004385A2 true CO2023004385A2 (es) 2023-04-27

Family

ID=80469419

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0004385A CO2023004385A2 (es) 2020-09-08 2023-04-05 Dispositivo de retención celular

Country Status (8)

Country Link
US (2) US11801477B2 (es)
EP (1) EP4211222A1 (es)
JP (1) JP2023550227A (es)
KR (1) KR20230064615A (es)
AU (1) AU2021341821A1 (es)
CA (1) CA3191947A1 (es)
CO (1) CO2023004385A2 (es)
WO (1) WO2022055859A1 (es)

Family Cites Families (27)

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US4755300A (en) * 1985-12-23 1988-07-05 Haemonetics Corporation Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear
CA1302904C (en) * 1986-06-24 1992-06-09 Peter H. Knappe High recovery spiral wound membrane element
US5174896A (en) 1990-06-25 1992-12-29 Harmsco, Inc. Filtering system utilizing rotational flow and angled pleated filter media and method for making slanted pleated filter media
US5820767A (en) 1996-07-29 1998-10-13 Pall Corporation Method for quantitation of microorganism contamination of liquids
CN2749555Y (zh) 2001-11-06 2006-01-04 帕克-汉尼芬公司 过滤器元件
GB2390825B (en) * 2002-06-07 2005-08-17 Baldwin Filters Inc Environmentally friendly acid neutralizing cartridge
US6962660B2 (en) * 2002-09-25 2005-11-08 Master Spas, Inc. Fluid filter system with secondary flow path for augmented filtration
EP1788073B1 (en) 2004-08-17 2013-11-06 Kyushu Institute of Technology Porous sheet member for cell culture and, utilizing the same, bioreactor and culturing method
DE102005014360A1 (de) 2005-03-30 2006-10-05 Hydac Filtertechnik Gmbh Filterelement
BRPI0803630B1 (pt) 2008-06-05 2018-11-06 Fundacao Univ Federal De Sao Carlos Ufscar biorreator de escoamento em vórtices de taylor para cultivo celular
ATE552217T1 (de) 2008-07-28 2012-04-15 Aptwater Inc Radialstrom-membranbiofilmreaktor
DE102009005980A1 (de) 2009-01-23 2010-07-29 Mahle International Gmbh Hydraulikfilterelement und zugehöriges Herstellungsverfahren
EP2446077B1 (en) * 2009-06-23 2016-05-18 3M Innovative Properties Company Functionalized nonwoven article
FR2948294B1 (fr) 2009-07-21 2011-08-12 Data Plastique Dispositif de filtration
DE102011001015B4 (de) 2011-03-02 2016-03-03 Nordson Holdings S.À.R.L. & Co. Kg Filterelement für die Filtrierung eines Fluids und daraus gebildete Filtereinheit
EP2732863A1 (en) 2012-11-15 2014-05-21 Pall Corporation Filter Element
DE102013020752B4 (de) 2013-12-11 2020-10-01 Hydac Filtertechnik Gmbh Verfahren zum Herstellen eines Filterelementes und Filterelement
US9839866B2 (en) * 2014-05-30 2017-12-12 Pall Corporation Filter elements and methods for filtering fluids
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GB2549732A (en) 2016-04-26 2017-11-01 Apacor Ltd Filter apparatus and filter device for biological samples
WO2018132512A1 (en) 2017-01-10 2018-07-19 Massachusetts Institute Of Technology Constructs and cells for enhanced protein expression
WO2018183971A1 (en) 2017-04-01 2018-10-04 Massachusetts Institute Of Technology Systems and methods for manufacturing biologically-produced products
WO2018183848A1 (en) 2017-04-01 2018-10-04 Massachusetts Institute Of Technology Media for microorgainsm culture and related compositions and methods
EP3675988A2 (en) 2017-08-31 2020-07-08 Massachusetts Institute of Technology Hollow fibre membrane filtration systems and methods for manufacturing biologically-produced products
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US20190247560A1 (en) * 2018-02-13 2019-08-15 Gambro Lundia Ab Extracorporeal devices and methods of treating complement factor related diseases

Also Published As

Publication number Publication date
US11801477B2 (en) 2023-10-31
AU2021341821A1 (en) 2023-03-23
WO2022055859A9 (en) 2022-06-09
US20240009625A1 (en) 2024-01-11
JP2023550227A (ja) 2023-12-01
CA3191947A1 (en) 2022-03-17
US20220072478A1 (en) 2022-03-10
EP4211222A1 (en) 2023-07-19
WO2022055859A1 (en) 2022-03-17
KR20230064615A (ko) 2023-05-10

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