CO2022008023A2 - Formas sólidas de 2-[3-[4-amino-3-(2-fluoro-4-fenoxi-fenil)pirazolo[3,4-d]pirimidin-1-il]piperidina-1-carbonil]-4-metil-4-[4-(oxetan-3-il)piperazin-1-il]pent-2-enenitrilo - Google Patents

Formas sólidas de 2-[3-[4-amino-3-(2-fluoro-4-fenoxi-fenil)pirazolo[3,4-d]pirimidin-1-il]piperidina-1-carbonil]-4-metil-4-[4-(oxetan-3-il)piperazin-1-il]pent-2-enenitrilo

Info

Publication number
CO2022008023A2
CO2022008023A2 CONC2022/0008023A CO2022008023A CO2022008023A2 CO 2022008023 A2 CO2022008023 A2 CO 2022008023A2 CO 2022008023 A CO2022008023 A CO 2022008023A CO 2022008023 A2 CO2022008023 A2 CO 2022008023A2
Authority
CO
Colombia
Prior art keywords
enenitrile
oxetan
pent
pyrazolo
piperazin
Prior art date
Application number
CONC2022/0008023A
Other languages
English (en)
Inventor
Pasit Phiasivongsa
Katherine Chu
Jiang Zhu
Kolbot By
Mohammad Masjedizadeh
Original Assignee
Principia Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Principia Biopharma Inc filed Critical Principia Biopharma Inc
Publication of CO2022008023A2 publication Critical patent/CO2022008023A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Formas sólidas del compuesto (I): se describen. También se describen composiciones farmacéuticas que los comprenden, métodos para tratar desórdenes y condiciones mediadas por actividad de BTK usando los mismos, y métodos para preparar el Compuesto (I) y formas cristalinas de este.
CONC2022/0008023A 2019-12-20 2022-06-06 Formas sólidas de 2-[3-[4-amino-3-(2-fluoro-4-fenoxi-fenil)pirazolo[3,4-d]pirimidin-1-il]piperidina-1-carbonil]-4-metil-4-[4-(oxetan-3-il)piperazin-1-il]pent-2-enenitrilo CO2022008023A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962951958P 2019-12-20 2019-12-20
US202063122309P 2020-12-07 2020-12-07
PCT/US2020/065689 WO2021127231A1 (en) 2019-12-20 2020-12-17 Solid forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

Publications (1)

Publication Number Publication Date
CO2022008023A2 true CO2022008023A2 (es) 2022-09-09

Family

ID=74186901

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2022/0008023A CO2022008023A2 (es) 2019-12-20 2022-06-06 Formas sólidas de 2-[3-[4-amino-3-(2-fluoro-4-fenoxi-fenil)pirazolo[3,4-d]pirimidin-1-il]piperidina-1-carbonil]-4-metil-4-[4-(oxetan-3-il)piperazin-1-il]pent-2-enenitrilo

Country Status (13)

Country Link
US (2) US11708370B2 (es)
EP (1) EP4076670A1 (es)
JP (1) JP2023507125A (es)
KR (1) KR20220119646A (es)
CN (1) CN115515687A (es)
AU (1) AU2020405096A1 (es)
BR (1) BR112022011516A2 (es)
CA (1) CA3162219A1 (es)
CO (1) CO2022008023A2 (es)
IL (1) IL293849A (es)
MX (1) MX2022007553A (es)
TW (1) TW202138371A (es)
WO (1) WO2021127231A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023244562A1 (en) 2022-06-14 2023-12-21 Principia Biopharma Inc. Crystalline forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1- yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1612866A (zh) 2001-11-14 2005-05-04 特瓦制药工业有限公司 无定形和结晶形的氯沙坦钾及其制备方法
CN104822681B (zh) 2012-09-10 2018-01-30 普林斯匹亚生物制药公司 作为激酶抑制剂的吡唑并嘧啶化合物
JP6504548B2 (ja) * 2014-02-21 2019-04-24 プリンシピア バイオファーマ インコーポレイテッド Ｂｔｋ阻害剤の塩および固体形態
CN110483521B (zh) * 2018-05-14 2022-06-07 杭州和正医药有限公司 一种可逆共价布鲁顿酪氨酸激酶抑制剂、药物组合物及其应用
WO2022081512A1 (en) 2020-10-12 2022-04-21 Synubi Pharmaceuticals Llc Compositions and methods of treatment of neuroinflammatory diseases with bruton's tyrosine kinase inhibitors

Also Published As

Publication number Publication date
AU2020405096A1 (en) 2022-08-11
MX2022007553A (es) 2022-07-19
IL293849A (en) 2022-08-01
EP4076670A1 (en) 2022-10-26
US11708370B2 (en) 2023-07-25
KR20220119646A (ko) 2022-08-30
US20210198264A1 (en) 2021-07-01
TW202138371A (zh) 2021-10-16
CA3162219A1 (en) 2021-06-24
US20230399330A1 (en) 2023-12-14
WO2021127231A1 (en) 2021-06-24
CN115515687A (zh) 2022-12-23
JP2023507125A (ja) 2023-02-21
BR112022011516A2 (pt) 2022-08-23

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