CO2022004947A2 - Regímenes de dosificación para el tratamiento de pacientes con carcinoma de células escamosas avanzado localmente - Google Patents
Regímenes de dosificación para el tratamiento de pacientes con carcinoma de células escamosas avanzado localmenteInfo
- Publication number
- CO2022004947A2 CO2022004947A2 CONC2022/0004947A CO2022004947A CO2022004947A2 CO 2022004947 A2 CO2022004947 A2 CO 2022004947A2 CO 2022004947 A CO2022004947 A CO 2022004947A CO 2022004947 A2 CO2022004947 A2 CO 2022004947A2
- Authority
- CO
- Colombia
- Prior art keywords
- treatment
- cell carcinoma
- squamous cell
- patients
- locally advanced
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/5545—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having eight-membered rings not containing additional condensed or non-condensed nitrogen-containing 3-7 membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
Se proporcionan métodos de administración de inhibidores de la proteína de la apoptosis ("IAP"), o sales farmacéuticamente aceptables de los mismos, para el tratamiento de un paciente humano que tenga un carcinoma de células escamosas localmente avanzado
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962905703P | 2019-09-25 | 2019-09-25 | |
US202063016762P | 2020-04-28 | 2020-04-28 | |
EP20184601 | 2020-07-07 | ||
PCT/EP2020/076994 WO2021058794A1 (en) | 2019-09-25 | 2020-09-25 | Dosing regimens for treatment of patients with locally advanced squamous cell carcinoma |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2022004947A2 true CO2022004947A2 (es) | 2022-08-30 |
Family
ID=72644266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2022/0004947A CO2022004947A2 (es) | 2019-09-25 | 2022-04-20 | Regímenes de dosificación para el tratamiento de pacientes con carcinoma de células escamosas avanzado localmente |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP4034102A1 (es) |
JP (1) | JP2022550037A (es) |
KR (1) | KR20220088700A (es) |
CN (1) | CN114727984A (es) |
AU (1) | AU2020356356A1 (es) |
BR (1) | BR112022005624A2 (es) |
CA (1) | CA3151770A1 (es) |
CO (1) | CO2022004947A2 (es) |
IL (1) | IL291682A (es) |
MX (1) | MX2022003628A (es) |
WO (1) | WO2021058794A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024022275A1 (zh) * | 2022-07-29 | 2024-02-01 | 苏州科睿思制药有限公司 | Xevinapant的晶型及其制备方法和用途 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2019671B1 (en) | 2006-05-05 | 2014-09-24 | The Regents Of The University Of Michigan | Intermediates for the preparation of bivalent smac mimetics |
EP2024362A4 (en) | 2006-05-16 | 2012-01-25 | Pharmascience Inc | IAP BIR DOMAIN BINDING COMPOUNDS |
US20100113326A1 (en) | 2006-07-24 | 2010-05-06 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
US20100144650A1 (en) | 2006-07-24 | 2010-06-10 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
PE20110218A1 (es) | 2006-08-02 | 2011-04-01 | Novartis Ag | DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS |
BRPI0810522B8 (pt) | 2007-04-13 | 2021-05-25 | Univ Michigan Regents | compostos miméticos diazo bicíclicos de smac, composição farmacêutica e kit compreendendo ditos compostos e uso dos mesmos para o tratamento de câncer |
EP2296650B1 (en) | 2008-05-16 | 2020-05-06 | Novartis AG | Immunomodulation by iap inhibitors |
US20100317593A1 (en) | 2009-06-12 | 2010-12-16 | Astrazeneca Ab | 2,3-dihydro-1h-indene compounds |
EP2491041B1 (en) | 2009-10-23 | 2017-08-09 | The Regents of the University of Michigan | Bivalent diazo bicyclic smac mimetics and the uses thereof |
WO2011059763A2 (en) | 2009-10-28 | 2011-05-19 | Joyant Pharmaceuticals, Inc. | Dimeric smac mimetics |
BR112012010698A2 (pt) | 2009-11-05 | 2016-11-29 | Uab Research Foundation | método para tratamento de um sujeito com câncer, método de triagem de uma célula de câncer de mama, e , anticorpo |
JP2014528409A (ja) | 2011-09-30 | 2014-10-27 | テトラロジック ファーマシューティカルズ コーポレーション | 増殖性疾患(がん)の治療において使用するためのSMAC模倣体(ビリナパント(birinapant)) |
US8859541B2 (en) | 2012-02-27 | 2014-10-14 | Boehringer Ingelheim International Gmbh | 6-alkynylpyridines |
AU2013306087B2 (en) | 2012-08-23 | 2017-08-10 | The Regents Of The University Of Michigan | Bivalent inhibitors of IAP proteins and therapeutic methods using the same |
CA2896577C (en) | 2012-11-30 | 2024-01-23 | Sanford-Burnham Medical Research Institute | Inhibitor of apoptosis protein (iap) antagonists |
WO2014121178A1 (en) | 2013-02-04 | 2014-08-07 | Tetralogic Pharmaceuticals Corp. | Smac mimetic method of treatment |
US9249151B2 (en) | 2013-08-23 | 2016-02-02 | Boehringer Ingelheim International Gmbh | Bis-amido pyridines |
US9278978B2 (en) | 2013-08-23 | 2016-03-08 | Boehringer Ingelheim International Gmbh | 6-Alkynyl Pyridine |
HUE056297T2 (hu) | 2013-12-20 | 2022-02-28 | Astex Therapeutics Ltd | Biciklikus heterociklusos vegyületek és ezek terápiában történõ alkalmazása |
AR101479A1 (es) | 2014-08-11 | 2016-12-21 | Boehringer Ingelheim Int | Derivados de 6-alquinil-piridina |
EP3200775B1 (en) | 2014-10-03 | 2019-11-20 | Novartis AG | Combination therapies |
WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
AU2015360095B2 (en) * | 2014-12-09 | 2020-02-27 | Advenchen Laboratories Nanjing Ltd | Quinoline derivative against non-small cell lung cancer |
CA2916970A1 (en) | 2016-01-08 | 2017-07-08 | Pharmascience Inc. | A smac mimetic compound for use in the treatment of proliferative diseases |
WO2017143449A1 (en) | 2016-02-24 | 2017-08-31 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
CN110475567A (zh) | 2017-03-31 | 2019-11-19 | 勃林格殷格翰国际有限公司 | 抗癌组合疗法 |
-
2020
- 2020-09-25 AU AU2020356356A patent/AU2020356356A1/en active Pending
- 2020-09-25 WO PCT/EP2020/076994 patent/WO2021058794A1/en active Application Filing
- 2020-09-25 EP EP20780195.2A patent/EP4034102A1/en active Pending
- 2020-09-25 JP JP2022518772A patent/JP2022550037A/ja active Pending
- 2020-09-25 CN CN202080079488.5A patent/CN114727984A/zh active Pending
- 2020-09-25 CA CA3151770A patent/CA3151770A1/en active Pending
- 2020-09-25 BR BR112022005624A patent/BR112022005624A2/pt not_active Application Discontinuation
- 2020-09-25 KR KR1020227013744A patent/KR20220088700A/ko unknown
- 2020-09-25 MX MX2022003628A patent/MX2022003628A/es unknown
-
2022
- 2022-03-24 IL IL291682A patent/IL291682A/en unknown
- 2022-04-20 CO CONC2022/0004947A patent/CO2022004947A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP4034102A1 (en) | 2022-08-03 |
IL291682A (en) | 2022-05-01 |
AU2020356356A1 (en) | 2022-05-12 |
CA3151770A1 (en) | 2021-04-01 |
BR112022005624A2 (pt) | 2022-07-12 |
MX2022003628A (es) | 2022-07-21 |
KR20220088700A (ko) | 2022-06-28 |
WO2021058794A1 (en) | 2021-04-01 |
JP2022550037A (ja) | 2022-11-30 |
CN114727984A (zh) | 2022-07-08 |
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