CO2021017479A2 - Derivados de pirido [2,3-d] pirimidina como inhibidores de la replicación del virus de inmunodeficiencia humana - Google Patents

Derivados de pirido [2,3-d] pirimidina como inhibidores de la replicación del virus de inmunodeficiencia humana

Info

Publication number
CO2021017479A2
CO2021017479A2 CONC2021/0017479A CO2021017479A CO2021017479A2 CO 2021017479 A2 CO2021017479 A2 CO 2021017479A2 CO 2021017479 A CO2021017479 A CO 2021017479A CO 2021017479 A2 CO2021017479 A2 CO 2021017479A2
Authority
CO
Colombia
Prior art keywords
immunodeficiency virus
human immunodeficiency
pyrido
inhibitors
virus replication
Prior art date
Application number
CONC2021/0017479A
Other languages
English (en)
Inventor
Eric P Gillis
Christiana Iwuagwu
Original Assignee
Viiv Healthcare Uk No 5 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viiv Healthcare Uk No 5 Ltd filed Critical Viiv Healthcare Uk No 5 Ltd
Publication of CO2021017479A2 publication Critical patent/CO2021017479A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se dan a conocer el compuesto Y las sales del mismo aptas para uso farmacéutico, y composiciones y métodos para el tratamiento de la infección por el virus de inmunodeficiencia humana (VIH):
CONC2021/0017479A 2019-06-19 2021-12-20 Derivados de pirido [2,3-d] pirimidina como inhibidores de la replicación del virus de inmunodeficiencia humana CO2021017479A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962863406P 2019-06-19 2019-06-19
PCT/IB2020/055653 WO2020254985A1 (en) 2019-06-19 2020-06-17 Pyrido[2,3-d]pyrimidine derivatives as inhibitors of human immunodeficiency virus replication

Publications (1)

Publication Number Publication Date
CO2021017479A2 true CO2021017479A2 (es) 2022-04-19

Family

ID=71738195

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2021/0017479A CO2021017479A2 (es) 2019-06-19 2021-12-20 Derivados de pirido [2,3-d] pirimidina como inhibidores de la replicación del virus de inmunodeficiencia humana

Country Status (29)

Country Link
US (1) US20210323967A1 (es)
EP (1) EP3986561B1 (es)
JP (1) JP2022537047A (es)
KR (1) KR20220024608A (es)
CN (1) CN114245795B (es)
AR (1) AR119174A1 (es)
AU (1) AU2020295793B2 (es)
BR (1) BR112021025655A2 (es)
CA (1) CA3143136A1 (es)
CL (1) CL2021003388A1 (es)
CO (1) CO2021017479A2 (es)
CR (1) CR20210664A (es)
DK (1) DK3986561T3 (es)
ES (1) ES2974541T3 (es)
FI (1) FI3986561T3 (es)
HR (1) HRP20240501T1 (es)
HU (1) HUE065762T2 (es)
IL (1) IL288750A (es)
LT (1) LT3986561T (es)
MA (1) MA56526B1 (es)
MD (1) MD3986561T2 (es)
MX (1) MX2021016149A (es)
PE (1) PE20220510A1 (es)
PL (1) PL3986561T3 (es)
PT (1) PT3986561T (es)
RS (1) RS65304B1 (es)
SI (1) SI3986561T1 (es)
UY (1) UY38755A (es)
WO (1) WO2020254985A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA202190854A1 (ru) 2018-10-24 2021-08-17 ВАЙВ ХЕЛТКЕР ЮКей (№5) ЛИМИТЕД Ингибиторы репликации вируса иммунодефицита человека
WO2021116872A1 (en) * 2019-12-09 2021-06-17 Viiv Healthcare Company Pharmaceutical compositions comprising cabotegravir
AU2021231447A1 (en) * 2020-03-06 2022-09-22 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
AU2022362855A1 (en) 2021-10-13 2024-05-02 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011000149A (es) * 2008-07-02 2011-02-24 Avexa Ltd Compuestos que tienen propiedades antivirales.
CN102464654B (zh) 2010-11-12 2016-01-13 上海泓博智源医药技术有限公司 抗病毒化合物
WO2013006738A1 (en) 2011-07-06 2013-01-10 Gilead Sciences, Inc. Compounds for the treatment of hiv
CN102863512B (zh) 2011-07-07 2016-04-20 上海泓博智源医药技术有限公司 抗病毒化合物
PT2943487T (pt) 2013-01-09 2016-12-15 Gilead Sciences Inc Heteroarilos de 5 membros e sua utilização como agentes antivirais
TW201443037A (zh) 2013-01-09 2014-11-16 Gilead Sciences Inc 治療用化合物
EP2943493B1 (en) 2013-01-09 2017-08-02 Gilead Sciences, Inc. Therapeutic compounds for the treatment of viral infections
TWI694071B (zh) 2013-03-01 2020-05-21 美商基利科學股份有限公司 治療反轉錄病毒科(Retroviridae)病毒感染之治療性化合物
WO2015130966A1 (en) 2014-02-28 2015-09-03 Gilead Sciences, Inc. Antiviral agents
US10202353B2 (en) 2014-02-28 2019-02-12 Gilead Sciences, Inc. Therapeutic compounds
NZ729150A (en) 2014-08-29 2018-02-23 Gilead Sciences Inc Antiretroviral agents
PL3597646T3 (pl) * 2016-08-19 2023-12-11 Gilead Sciences, Inc. Związki terapeutyczne użyteczne do profilaktycznego lub terapeutycznego leczenia zakażenia wirusem HIV
ES2826748T3 (es) * 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
TW201906834A (zh) * 2017-05-02 2019-02-16 英商Viiv醫療保健英國(No.5)有限公司 人類免疫不全病毒複製之抑制劑
UY38559A (es) * 2019-02-01 2020-07-31 Viiv Healthcare Uk No 5 Ltd Inhibidores de la replicación del virus de la inmunodeficiencia humana

Also Published As

Publication number Publication date
CL2021003388A1 (es) 2022-09-30
CN114245795A (zh) 2022-03-25
LT3986561T (lt) 2024-04-25
EP3986561B1 (en) 2024-02-14
BR112021025655A2 (pt) 2022-02-01
CN114245795B (zh) 2024-08-06
CR20210664A (es) 2022-01-21
JP2022537047A (ja) 2022-08-23
IL288750A (en) 2022-02-01
HRP20240501T1 (hr) 2024-07-05
AU2020295793A1 (en) 2022-01-20
DK3986561T3 (da) 2024-03-04
RS65304B1 (sr) 2024-04-30
CA3143136A1 (en) 2020-12-24
UY38755A (es) 2020-11-30
MA56526A (fr) 2022-04-27
PL3986561T3 (pl) 2024-06-10
MD3986561T2 (ro) 2024-06-30
US20210323967A1 (en) 2021-10-21
MX2021016149A (es) 2022-05-18
MA56526B1 (fr) 2024-05-31
AR119174A1 (es) 2021-12-01
TW202115055A (zh) 2021-04-16
PT3986561T (pt) 2024-03-15
FI3986561T3 (fi) 2024-05-02
WO2020254985A1 (en) 2020-12-24
EP3986561A1 (en) 2022-04-27
SI3986561T1 (sl) 2024-04-30
HUE065762T2 (hu) 2024-06-28
KR20220024608A (ko) 2022-03-03
PE20220510A1 (es) 2022-04-07
ES2974541T3 (es) 2024-06-27
AU2020295793B2 (en) 2023-07-06

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