CO2020011984A2 - Cepa del virus de la fiebre amarilla viva atenuada adaptada para el crecimiento en células vero y composición de vacuna que la comprende - Google Patents

Cepa del virus de la fiebre amarilla viva atenuada adaptada para el crecimiento en células vero y composición de vacuna que la comprende

Info

Publication number
CO2020011984A2
CO2020011984A2 CONC2020/0011984A CO2020011984A CO2020011984A2 CO 2020011984 A2 CO2020011984 A2 CO 2020011984A2 CO 2020011984 A CO2020011984 A CO 2020011984A CO 2020011984 A2 CO2020011984 A2 CO 2020011984A2
Authority
CO
Colombia
Prior art keywords
yellow fever
fever virus
live attenuated
vero cells
virus strain
Prior art date
Application number
CONC2020/0011984A
Other languages
English (en)
Inventor
Manuel Vangelisti
Nathalie Mantel
Yves Girerd-Chambaz
Fabienne Piras
Original Assignee
Sanofi Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Pasteur filed Critical Sanofi Pasteur
Publication of CO2020011984A2 publication Critical patent/CO2020011984A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/08—Inactivation or attenuation by serial passage of virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24161—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24161—Methods of inactivation or attenuation
    • C12N2770/24164—Methods of inactivation or attenuation by serial passage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La invención se refiere a una cepa del virus de la fiebre amarilla viva atenuada adaptada para crecer en células Vero a partir de una subcepa del virus de la fiebre amarilla 17D parental que no está adaptada para crecer en células Vero, donde dicha cepa del virus de la fiebre amarilla viva atenuada es menos neurovirulenta que dicha subcepa del virus de la fiebre amarilla 17D parental.
CONC2020/0011984A 2018-04-06 2020-09-28 Cepa del virus de la fiebre amarilla viva atenuada adaptada para el crecimiento en células vero y composición de vacuna que la comprende CO2020011984A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18305405.5A EP3549603A1 (en) 2018-04-06 2018-04-06 Live-attenuated yellow fever virus strain adapted to grow on vero cells and vaccine composition comprising the same
PCT/EP2019/058268 WO2019192997A1 (en) 2018-04-06 2019-04-02 Live-attenuated yellow fever virus strain adapted to grow on vero cells and vaccine composition comprising the same

Publications (1)

Publication Number Publication Date
CO2020011984A2 true CO2020011984A2 (es) 2021-02-08

Family

ID=62046805

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2020/0011984A CO2020011984A2 (es) 2018-04-06 2020-09-28 Cepa del virus de la fiebre amarilla viva atenuada adaptada para el crecimiento en células vero y composición de vacuna que la comprende

Country Status (14)

Country Link
US (2) US11471521B2 (es)
EP (2) EP3549603A1 (es)
JP (1) JP7370338B2 (es)
KR (1) KR20200140292A (es)
CN (1) CN111918669A (es)
AR (1) AR114471A1 (es)
AU (1) AU2019249329A1 (es)
BR (1) BR112020018879A2 (es)
CA (1) CA3095438A1 (es)
CO (1) CO2020011984A2 (es)
PE (1) PE20210317A1 (es)
SG (1) SG11202009439YA (es)
WO (1) WO2019192997A1 (es)
ZA (1) ZA202006280B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3549603A1 (en) 2018-04-06 2019-10-09 Sanofi Pasteur Live-attenuated yellow fever virus strain adapted to grow on vero cells and vaccine composition comprising the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2589392B1 (en) 2008-03-05 2016-11-30 Sanofi Pasteur Process for stabilizing an adjuvant containing vaccine composition
CA3150411C (en) * 2009-07-31 2023-09-12 Pnuvax Inc. High yield yellow fever virus strain with increased propagation in cells
AR079970A1 (es) * 2010-07-23 2012-02-29 Xcellerex Inc Cepas de alto rendimiento del virus de la fiebre amarilla con una propagacion incrementada en las celulas
SG11201500412TA (en) 2012-07-24 2015-02-27 Sanofi Pasteur Vaccine compositions
EP3549603A1 (en) * 2018-04-06 2019-10-09 Sanofi Pasteur Live-attenuated yellow fever virus strain adapted to grow on vero cells and vaccine composition comprising the same

Also Published As

Publication number Publication date
BR112020018879A2 (pt) 2021-01-26
KR20200140292A (ko) 2020-12-15
US20220047692A1 (en) 2022-02-17
ZA202006280B (en) 2022-06-29
US11471521B2 (en) 2022-10-18
SG11202009439YA (en) 2020-10-29
CN111918669A (zh) 2020-11-10
TW202003028A (zh) 2020-01-16
AR114471A1 (es) 2020-09-09
WO2019192997A1 (en) 2019-10-10
JP2021520384A (ja) 2021-08-19
EP3549603A1 (en) 2019-10-09
CA3095438A1 (en) 2019-10-10
JP7370338B2 (ja) 2023-10-27
EP3773701A1 (en) 2021-02-17
RU2020136260A (ru) 2022-05-06
AU2019249329A1 (en) 2020-12-03
PE20210317A1 (es) 2021-02-16
US20210154289A1 (en) 2021-05-27
US11452772B2 (en) 2022-09-27

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