CO2019014476A2 - Detector con ruido de intervalo de fluorescencia reducido - Google Patents

Detector con ruido de intervalo de fluorescencia reducido

Info

Publication number
CO2019014476A2
CO2019014476A2 CONC2019/0014476A CO2019014476A CO2019014476A2 CO 2019014476 A2 CO2019014476 A2 CO 2019014476A2 CO 2019014476 A CO2019014476 A CO 2019014476A CO 2019014476 A2 CO2019014476 A2 CO 2019014476A2
Authority
CO
Colombia
Prior art keywords
detector
reduced fluorescence
range noise
fluorescence range
sensors
Prior art date
Application number
CONC2019/0014476A
Other languages
English (en)
Inventor
Joseph Pinto
Tracy H Fung
Poorya Sabounchi
Bernard Hirschbein
Tarun Khurana
Randall Smith
Wenyi Feng
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of CO2019014476A2 publication Critical patent/CO2019014476A2/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6402—Atomic fluorescence; Laser induced fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B19/00—Condensers, e.g. light collectors or similar non-imaging optics
    • G02B19/0004—Condensers, e.g. light collectors or similar non-imaging optics characterised by the optical means employed
    • G02B19/0019—Condensers, e.g. light collectors or similar non-imaging optics characterised by the optical means employed having reflective surfaces only (e.g. louvre systems, systems with multiple planar reflectors)
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B19/00—Condensers, e.g. light collectors or similar non-imaging optics
    • G02B19/0033—Condensers, e.g. light collectors or similar non-imaging optics characterised by the use
    • G02B19/0076—Condensers, e.g. light collectors or similar non-imaging optics characterised by the use for use with a detector
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/20—Filters
    • G02B5/22—Absorbing filters
    • G02B5/223—Absorbing filters containing organic substances, e.g. dyes, inks or pigments
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H01L27/14—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation and specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
    • H01L27/144—Devices controlled by radiation
    • H01L27/146—Imager structures
    • H01L27/14601—Structural or functional details thereof
    • H01L27/1462—Coatings
    • H01L27/14621—Colour filter arrangements
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H01L27/14—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation and specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
    • H01L27/144—Devices controlled by radiation
    • H01L27/146—Imager structures
    • H01L27/14601—Structural or functional details thereof
    • H01L27/14625—Optical elements or arrangements associated with the device
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H01L27/14—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation and specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
    • H01L27/144—Devices controlled by radiation
    • H01L27/146—Imager structures
    • H01L27/14643—Photodiode arrays; MOS imagers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Power Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Electromagnetism (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Optical Measuring Cells (AREA)
  • Optical Filters (AREA)

Abstract

En este documento se expone un dispositivo que comprende una estructura que define una superficie de detector configurada para soportar sustancias biológicas o químicas, y una matriz de sensores que comprende sensores de luz y circuitos para transmitir señales de datos usando los fotones detectados por los sensores de luz.
CONC2019/0014476A 2017-12-28 2019-12-20 Detector con ruido de intervalo de fluorescencia reducido CO2019014476A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762611464P 2017-12-28 2017-12-28
US201862644804P 2018-03-19 2018-03-19
PCT/US2018/063395 WO2019133182A1 (en) 2017-12-28 2018-11-30 Detector with reduced fluorescence range noise

Publications (1)

Publication Number Publication Date
CO2019014476A2 true CO2019014476A2 (es) 2020-04-13

Family

ID=67058128

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0014476A CO2019014476A2 (es) 2017-12-28 2019-12-20 Detector con ruido de intervalo de fluorescencia reducido

Country Status (23)

Country Link
US (4) US10551317B2 (es)
EP (2) EP3978908A1 (es)
JP (1) JP6827570B2 (es)
KR (2) KR102261632B1 (es)
CN (3) CN209624391U (es)
AU (2) AU2018397465A1 (es)
BR (1) BR112019028286B1 (es)
CA (2) CA3191105A1 (es)
CL (1) CL2019003784A1 (es)
CO (1) CO2019014476A2 (es)
CR (1) CR20190584A (es)
DK (1) DK3732468T3 (es)
ES (1) ES2906809T3 (es)
IL (1) IL271293B (es)
MX (1) MX2019015855A (es)
MY (1) MY194752A (es)
PH (1) PH12019502900A1 (es)
RU (1) RU2738311C1 (es)
SA (1) SA519410862B1 (es)
SG (1) SG11201912255RA (es)
TW (1) TWI698638B (es)
WO (1) WO2019133182A1 (es)
ZA (1) ZA201908274B (es)

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IL271293B (en) 2021-03-25
EP3978908A1 (en) 2022-04-06
AU2018397465A1 (en) 2020-01-16
PH12019502900A1 (en) 2020-09-14
DK3732468T3 (da) 2022-02-14
US20190204226A1 (en) 2019-07-04
CL2019003784A1 (es) 2020-07-10
EP3732468B1 (en) 2021-12-15
CN109975255B (zh) 2022-04-19
US10551317B2 (en) 2020-02-04
JP2020531797A (ja) 2020-11-05
KR20210066028A (ko) 2021-06-04
JP6827570B2 (ja) 2021-02-10
CN209624391U (zh) 2019-11-12
IL271293A (en) 2020-01-30
KR102261632B1 (ko) 2021-06-07
CA3067249C (en) 2023-04-25
ZA201908274B (en) 2021-04-28
KR102583715B1 (ko) 2023-10-04
ES2906809T3 (es) 2022-04-20
US20200166461A1 (en) 2020-05-28
AU2021203297B2 (en) 2023-05-18
KR20200017431A (ko) 2020-02-18
SG11201912255RA (en) 2020-01-30
US11333604B2 (en) 2022-05-17
CA3067249A1 (en) 2019-07-04
US20240094125A1 (en) 2024-03-21
NZ759983A (en) 2021-08-27
CN109975255A (zh) 2019-07-05
US20210003505A1 (en) 2021-01-07
WO2019133182A1 (en) 2019-07-04
CA3191105A1 (en) 2019-07-04
US11852586B2 (en) 2023-12-26
MX2019015855A (es) 2021-04-07
AU2021203297A1 (en) 2021-06-17
TWI698638B (zh) 2020-07-11
EP3732468A1 (en) 2020-11-04
TW201930878A (zh) 2019-08-01
BR112019028286A2 (pt) 2020-07-14
CR20190584A (es) 2020-03-06
EP3732468A4 (en) 2020-12-02
MY194752A (en) 2022-12-15
RU2738311C1 (ru) 2020-12-11
BR112019028286B1 (pt) 2021-10-26
CN115078317A (zh) 2022-09-20
US10883937B2 (en) 2021-01-05
US20220260492A1 (en) 2022-08-18
SA519410862B1 (ar) 2022-09-05

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